Dr. Rubén Francés

Professor of Immunology, Universidad Miguel Hernandez (IDiBE associate researcher)



Molecular Diagnostic, Prognostic and Therapy

+34 96 523 3796


  • Our main line of research focuses on the immunobiology of bacterial translocation and inflammation in the gut-liver axis, with a multidisciplinary approach aimed at understanding the interaction between the microbiome and the Immune System and identifying new potentially useful targets in the recovery of homeostasis in advanced chronic liver disease and in inflammatory bowel disease.


  • Previous positions:

1. Postdoctoral researcher at the Boston Medical Center, Boston, USA, 2003-2005.
2. Senior researcher of the Spains’s National Health System, 2006-2018.


  • PhD in Molecular anad Cellular Biology, Miguel Hernández University, Elche, Spain, 2001.
  • Degree Biology (Biochemistry and Molecular Biology), University of Valencia, Valencia, Spain, 1998.


Linares, R. et al. (2022)

Biomedicine & Pharmacotherapy, DOI: 10.1016/j.biopha.2022.112653

Transcriptional regulation of chemokine network by biologic monotherapy in ileum of patients with Crohn’s disease

Orts, B. et al. (2022)

Frontiers in Pharmacology, DOI: 10.3389/fphar.2021.795272

Clinical and Immunological Factors Associated with Recommended Trough Levels of Adalimumab and Infliximab in Patients with Crohn’s Disease

Caparrós, E. et al. (2021)

Gut Microbes, DOI: 10.1080/19490976.2021.1949096

Dysbiotic microbiota interactions in Crohn’s disease

Linares, R. et al. (2021)

The FASEB Journal, DOI: 10.1096/fj.202100481R

Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products

Gracia-Sancho, J. et al. (2021)

Nature Reviews Gastroenterology & Hepatology, DOI: 10.1038/s41575-020-00411-3

Role of liver sinusoidal endothelial cells in liver diseases

Gómez-Hurtado, I. et al. (2020)

Liver International, DOI: 10.1111/liv.14571

Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients

Caparrós, E. et al. (2020)

Cells, DOI: 10.3390/cells9051227

Liver Sinusoidal Endothelial Cells Contribute to Hepatic Antigen-Presenting Cell Function and Th17 Expansion in Cirrhosis