STAFF

Dr. Ana Marcela Giudici Besseghini

ASSOCIATE PROFESSOR OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, UNIVERSIDAD MIGUEL HERNANDEZ

 

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Unit
Molecular and Cellular Design
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Subunit
Structure-Function Relationships in Membrane Proteins
Group
Structure-function relationship of potassium channels
marcela@umh.es
+ 34 965 22 21 07

RESEARCH FIELDS

  • Structure-function relationship in membrane proteins
  • Lipid-Protein and Protein-Protein interactions in biological membranes
  • Protein-protein interactions.
  • Modulation of ion channel structure and function

PROFESSIONAL BACKGROUND

  • Previous positions:
    1. Fellowship program of the interuniversity cooperation program, AECI Spain. 1999.
    2. Predoctoral type II mixed grant from CONICET, Argentina. 2000-2005.
    3. Predoctoral grants program MAEC-AECI, Spain. 2005.
  • Postdoctoral positions:
    1. Assistant researcher from CONICET, Instituto de Investigaciones Biológicas, Universidad Nacional Mar del Plata, Argentina. 2008-2010.
    2. Senior researcher, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche, Universidad Miguel Hernández, Spain. 2010-present
    3. Associate profesor, Universidad Miguel Hernández, 2017-present
  • PhD in Biological Sciences, Universidad Nacional Mar del Plata, Argentina, 2005. Directed by Laura de la Canal and José Villalaín Boullón.
  • Degree in Biology 1999. Universidad Nacional de Mar del Plata.

REPRESENTATIVE PUBLICATIONS

Giudici, A.M. et al. (2021)

International Journal of Molecular Sciences, DOI: 10.3390/ijms22020490

Tetraoctylammonium, a Long Chain Quaternary Ammonium Blocker, Promotes a Noncollapsed, Resting-Like Inactivated State in KcsA

Renart, M.L. et al. (2020)

International Journal of Molecular Sciences, DOI: 10.3390/ijms21072554

Modulation of Function, Structure and Clustering of K+ Channels by Lipids: Lessons Learnt from KcsA

Poveda, J.A. et al. (2019)

Biochimica et Biophysica Acta (BBA) – Biomembranes, DOI: 10.1016/j.bbamem.2019.183029

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites

Renart, L.M. et al. (2019)

Scientific Reports, DOI: 10.1038/s41598-019-42405-5

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies

Giudici, A.M. et al. (2019)

International Journal of Molecular Sciences, DOI: 10.3390/ijms20030689

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study

Molina, M.L. et al. (2015)

Journal of Biological Chemistry, DOI: 10.1074/jbc.M115.669598

Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in the Potassium Channel from Streptomyces lividans (KcsA)

Poveda, J.A. et al. (2014)

Biochimica et Biophysica Acta (BBA) – Biomembranes, DOI: 10.1016/j.bbamem.2013.10.023

Lipid modulation of ion channels through specific binding sites