STAFF

Dr. Francisco Javier Gómez Pérez

Professor of Physical chemistry, Universidad Miguel Hernandez

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Unit
Molecular and Cellular Design

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Subunit
Molecular Recognizement and Protein Engineering

Group
Biothermodynamics of molecular recognition processes

jgomez@umh.es

+ 34 966 65 84 67

RESEARCH FIELDS 

  • Structural thermodynamical description of molecular recognition processes
  • Therdynamics of protein folding.
  • Development of strategies to prevent protein aggregation.

PROFESSIONAL BACKGROUND

  • Previous positions: 
    1. Predoctoral fellowship from Universidad Nacional de Educación a Distancia (U.N.E.D.). Department of Chemistry. 1989-1992.
    2. Postdoctoral Fellow. The Biocalorimetry Center. Departmet of Biology. The Johns Hopkins University. 1993–1995.
    3. Research Associate Scientist. The Biocalorimetry Center. Departmet of Biology. The Johns Hopkins University. 1995–1997
  • Postdoctoral positions: The Biocalorimetry Center. Departmet of Biology. The Johns Hopkins University. Structural thermodynamical description of molecular recognition processes (Prof. Ernesto Freire).
  • PhD programme: PhD degree with Honors and Prize to the best Thesis at the Chemistry program, Universidad Nacional de Educación a Distancia (U.N.E.D.) – Consejo Superior de Investigaciones Científicas (C.S.I.C.). Directors: Profs. José Laynez Vallejo and Rosa Mª Claramunt Vallespí, 1992.
  • Degree in Chemistry

REPRESENTATIVE PUBLICATIONS

Romero-Bevier M., et al. (2010)

PEDS: Protein Engineering, Design and Selection, DOI: 10.1093/protein/gzq045

The N-terminal domain of the enzyme I is a monomeric well-folded protein with a low conformational stability and residual structure in the unfolded state

Neira J.L. E. and Gómez J. (2004)

European Journal of Biochemistry, PMID: 10569937

Thermodynamic analysis of the conformational stability of the Streptomyces coelicolor histidine-phosphocarrier protein: characterization of cold denaturation and urea-protein.

Todd M.J. and J. Gómez J., et al. (2001)

Analytical Biochemistry, DOI: 10.1006/abio.2001.5218

Enzyme kinetics determined using calorimetry: A General Assay for Enzymatic Activity?

Gómez J. and Freire E. (1995)

Journal of Molecular Biology, DOI: 10.1017/S0954422414000031

Thermodynamic Mapping of the Inhibitor Binding Site of the Aspartic Protease Endothiapepsin.

Gómez J., et al. (1995)

Proteins: Structure, Function and Genetics, DOI: 10.1002/prot.340220410

The Heat Capacity of Proteins.