Dr. José Manuel González Navajas

Assistant Professor, Department of Pharmacology, Universidad Miguel Hernandez


Pharmacology and Immunology


Immunology of hepatic and digestive diseases

Immunology of liver and colon cancer

+ 34 965 91 39 28


  • Immunobiology of hepatic and digestive diseases.
  • Study of the role of the Inflammasome complex during chronic liver inflammation and cancer. 
  • Study of the impact of T helper 17 (Th17) cells on the development of liver cancer and the efficacy of immune checkpoint inhibition therapy.


  • Previous positions:
    1. Senior Researcher, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain, 2020-present.
    2. Associate Professor, Universidad Miguel Hernández (UMH), Spain, 2019-present.
    3. ‘Miguel Servet’ Researcher of the Spanish National Health System, FISABIO Foundation, Alicante General Hospital, Spain, 2010-2019.
    4. Assistant Project Scientist, Dept. of Medicine, University of California San Diego (UCSD), USA, 2010-2013.
  • Postdoctoral positions:
    1. Postdoctoral Employee, Dept. of Medicine, University of California San Diego (UCSD), USA, 2006-2010.
    2. Postdoctoral Fellowship, Spanish Association for the Study of the Liver (AEEH). Dept. of Medicine, University of California San Diego, USA, 2005-2006.
    3. Postdoctoral Fellowship, Dept. of Clinical Medicine, Universidad Miguel Hernández (UMH), Spain, 2004-2005.
  • PhD in Biology. Universidad de Alicante, Spain (2003).
  • Degree in Biology. Universidad de Alicante, Spain (1999).



Martínez-Cardona, C. et al. (2018)

Internatinal Journal of Cancer, DOI: 10.1002/ijc.31827

AIM2 deficiency reduces the development of hepatocellular carcinoma in mice.

Bertin, S. et al. (2015)

Mucosal Immunology, DOI:  10.1038/mi.2014.84

Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.

Lozano-Ruiz, B. et al. (2015)

Journal of Hepatology, DOI: 10.1016/j.jhep.2014.08.027

Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis.

González-Navajas, J. M. et al. (2012)

Nature Reviews Immunology , DOI:  10.1038/nri3133

Immunomodulatory functions of type I interferons.

González-Navajas, J. M. et al. (2010)

Journal of Experimental Medicine, DOI: 10.1084/jem.20101326

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production.

González-Navajas, J. M. et al. (2010)

Journal of Clinical Investigation, DOI: 10.1172/JCI40055

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice.