STAFF

Dr. José Manuel González Ros

Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez

]

Unit
Molecular and Cellular Design

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Subunit
Structure-function relationships in membrane proteins

Group
Structure-function of potassium ion channels

gonzalez.ros@umh.es

+ 34 966 65 87 57

RESEARCH FIELDS 

  • Structure/Function relationships in membrane proteins: Neuroreceptors and ion channels.
  • Lipid-Protein and Protein-Protein interactions in biological membranes.
  • Potential applications to drug discovery.

PROFESSIONAL BACKGROUND

  • Previous positions:
    1997, Catedrático. Univ. Miguel Hernández
    1987-97, Catedrático. Univ. Alicante
    1984-87, Catedrático. Univ. Islas Baleares
    1981-84, Assistant Professor. Medical College of Virginia, USA
    1980-81, Research Associate. Medical College of Virginia, USA
    1978-80, Research Fellow, Medical College of Virginia, USA
    1977-78, Prof. Adjunto Interino. Univ. Alcalá de Henares
    1976-77, Prof. Encargado. Univ. Complutense de Madrid
    1974-76, Prof. Ayudante. Univ. Complutense de Madrid
    Director, Institute of Molecular and Cellular Biology, 1998-2012.
  • Postdoctoral positions:
  • PhD in Biochemistry, 1977. Universidad Complutense de Madrid (Advisor: Prof. Antonio Ribera Blancafort)
  • Degree in Biological Sciences, 1974.

REPRESENTATIVE PUBLICATIONS

Poveda J.A., et al. (2019)

Biochimica et Biophysica Acta (BBA) – Biomembranes, DOI: 10.1016/j.bbamem.2019.183029

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites.

Renart M.L., et al. (2019)

Scientific Reports, DOI: 10.1038/s41598-019-42405-5

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies.

Giudici A.M., et al. (2019)

International Journal of  Molecular Sciences, DOI: 10.3390/ijms20030689

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study.

Renart M.L., et al. (2017)

The Journal of Biological Chemistry, DOI: doi:10.1074/jbc.M117.795807

Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.

Molina M.L., et al. (2015)

The Journal of Biological Chemistry, DOI: 10.1074/jbc.M115.669598

Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in the Potassium Channel From Streptomyces Lividans (KcsA).

Poveda J.A., et al. (2014)

Biochimica et Biophysica Acta (BBA) – Biomembranes, DOI: 10.1016/j.bbamem.2013.10.023

Lipid Modulation of Ion Channels Through Specific Binding Sites.

PATENTS AND AVAILABLE TECHNOLOGIES

A DEVICE FOR ADMINISTRATION OF MEDICATION BY IONTOPHORESIS FOR LOCAL-REGIONAL TREATMENT

Number: 90100236.0
Date: 1995