STAFF
Dr. José Manuel González Ros
Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez
Unit
Molecular and Cellular Design
Subunit
Structure-function relationships in membrane proteins
Group
Structure-function of potassium ion channels
gonzalez.ros@umh.es
+ 34 966 65 87 57
RESEARCH FIELDS
- Structure/Function relationships in membrane proteins: Neuroreceptors and ion channels.
- Lipid-Protein and Protein-Protein interactions in biological membranes.
- Potential applications to drug discovery.
PROFESSIONAL BACKGROUND
- Previous positions:
1997, Catedrático. Univ. Miguel Hernández
1987-97, Catedrático. Univ. Alicante
1984-87, Catedrático. Univ. Islas Baleares
1981-84, Assistant Professor. Medical College of Virginia, USA
1980-81, Research Associate. Medical College of Virginia, USA
1978-80, Research Fellow, Medical College of Virginia, USA
1977-78, Prof. Adjunto Interino. Univ. Alcalá de Henares
1976-77, Prof. Encargado. Univ. Complutense de Madrid
1974-76, Prof. Ayudante. Univ. Complutense de Madrid
Director, Institute of Molecular and Cellular Biology, 1998-2012.
- Postdoctoral positions:
- PhD in Biochemistry, 1977. Universidad Complutense de Madrid (Advisor: Prof. Antonio Ribera Blancafort)
- Degree in Biological Sciences, 1974.
REPRESENTATIVE PUBLICATIONS
Poveda J.A., et al. (2019)
Biochimica et Biophysica Acta (BBA) – Biomembranes, DOI: 10.1016/j.bbamem.2019.183029
Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites.
Renart M.L., et al. (2019)
Scientific Reports, DOI: 10.1038/s41598-019-42405-5
Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies.
Giudici A.M., et al. (2019)
International Journal of Molecular Sciences, DOI: 10.3390/ijms20030689
Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study.
Renart M.L., et al. (2017)
The Journal of Biological Chemistry, DOI: doi:10.1074/jbc.M117.795807
Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel.
Molina M.L., et al. (2015)
The Journal of Biological Chemistry, DOI: 10.1074/jbc.M115.669598
Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in the Potassium Channel From Streptomyces Lividans (KcsA).
Poveda J.A., et al. (2014)
Biochimica et Biophysica Acta (BBA) – Biomembranes, DOI: 10.1016/j.bbamem.2013.10.023
Lipid Modulation of Ion Channels Through Specific Binding Sites.
PATENTS AND AVAILABLE TECHNOLOGIES
A DEVICE FOR ADMINISTRATION OF MEDICATION BY IONTOPHORESIS FOR LOCAL-REGIONAL TREATMENT
Number: 90100236.0
Date: 1995