Dr. Ángel Nadal

Professor of Physiology, Universidad Miguel Hernandez


Molecular and Cellular Design


Environmental Signaling and Disease

Diabetes Research Unit

+34 96 522 2002


  • We work to understand the role that estrogen receptors ERα, ERβ and GPER1 have in the physiology of the islet of Langerhans. This will give light on how estrogens influence the plasticity of the endocrine pancreas during the adaptation to pregnancy and obesity. We are interested in the role that endocrine disruptors, particularly those with estrogenic activity, have in the etiology of Diabetes.


  • Previous positions:

1. Associate Professor, Department of Physiology, Miguel Hernández University of Elche, Spain, 1998-2009.
2. Lecturer in Physiology, Physiology Group, King’s College London, London, UK, 1995-1996.

  • Postdoctoral positions:

1. Department of Physiology, Miguel Hernández University of Elche, Alicante, Spain, 1997-1998.
2. Physiology Group, King’s College London, London, UK, 1993-1995.


  • PhD in Chemistry, Neuroscience Program, Institute of Neurosciences, University of Alicante, Alicante, Spain, 1992.
  • Degree in Chemistry (Biochemistry and Molecular Biology), Autonomous University of Madrid, Madrid, Spain, 1989.


Marroquí, L. et al. (2021)

Chemosphere, DOI: 10.1016/j.chemosphere.2020.129051

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Martínez-Pinna J., marroquí L., et al. (2019)

Diabetologia, DOI: 10.1007/s00125-019-4925-y

Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells.

Nadal A., et al. (2017)

Nature Reviews Endocrinology, DOI: 10.1038/nrendo.2017.51

Endocrine-disrupting chemicals and the regulation of energy balance.

Villar-Pazos S., Martínez-Pinna J., et al. (2017)

Scientific Reports, DOI: 10.1038/s41598-017-11995-3

Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells.

García-Arévalo M., et al. (2016)

Endocrinology, DOI: 10.1210/en.2016-1390

Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic β-Cell Growth During Early Life in Male Mice Offspring.

Alonso-Magdalena P., et al. (2013)

Diabetes, DOI: 10.2337/db12-1562

Antidiabetic actions of an ERβ selective agonist.


Utilización del 17beta-estradiol, sus análogos y derivados en el tratamiento de la diabetes mellitus y sus manifestaciones

Inventors: B. Soria, A. Nadal, C. Ripoll, J.M. Rovira, E. Andreu, O. Laribi y T. León-Quinto.
Number: P9800625.
Date: 24 de marzo 1998
Countries: Spain