{"id":2005,"date":"2023-07-04T09:05:52","date_gmt":"2023-07-04T09:05:52","guid":{"rendered":"https:\/\/newidibe.zeus.umh.es\/?page_id=2005"},"modified":"2024-12-02T11:49:19","modified_gmt":"2024-12-02T11:49:19","slug":"diabetes-research-unit-unibad","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/diabetes-research-unit-unibad\/","title":{"rendered":"DIABETES RESEARCH UNIT (UNIBAD)"},"content":{"rendered":"

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Diabetes Research (unibad)<\/b><\/span><\/h1>\n

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The Diabetes Research Unit is composed of three research groups and their research is focused on different aspects related to type 1, type 2 and gestational diabetes.<\/p>\n

https:\/\/diabetes.umh.es\/<\/a>\u00a0<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” hover_enabled=”0″ header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Islet Cell Signaling Lab<\/strong><\/b><\/span><\/h2>\n

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We work to understand how chemical pollutants influence glucose homeostasis. Our ultimate goal is to translate this knowledge into actions to decrease the prevalence of diabetes and related metabolic disorders.<\/p>\n

https:\/\/isletcellsignal.umh.es\/<\/a>\u00a0<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Angel Nadal” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2024\/11\/AN5_.png” _builder_version=”4.17.4″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-angel-nadal\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Juan Mart\u00ednez-Pinna” position=”Investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Juan-Martinez-Pinna.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-juan-martinez-pinna\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Esther Fuentes” position=”Investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Esther-Fuentes.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-esther-fuentes\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Diabesity And Islet Research Lab<\/strong><\/b><\/span><\/h2>\n

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The Diabesity and Islet Research Lab is committed to uncovering the pathophysiology of gestational diabetes mellitus and its significance in the later development of type 2 diabetes, with particular emphasis on obesity as risk factor. We are also interested in better understanding the role of metabolism-disrupting chemicals in the occurrence of metabolic disorders. Our studies are mainly focused on the pancreatic beta and alpha-cells, but also in other tissues involved in glucose homeostasis. The ultimate goal is to determine new molecular targets and contribute to develop therapeutic and prevention strategies.<\/p>\n

https:\/\/dialab.umh.es\/<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Paloma Alonso-Magdalena” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Paloma-Alonso.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-paloma-alonso-magdalena\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Iv\u00e1n Quesada” position=”Investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Ivan-Quesada.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-ivan-quesada\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Sergi Soriano” position=”Investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/07\/sergi-soriano-ubeda-1.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-sergi-soriano\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Islet Biology Lab<\/strong><\/b><\/span><\/h2>\n

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The main interest of this group is understanding pancreatic islet function and survival in health and diabetes. The goal is to comprehend the molecular differences between alpha and beta cells that allow the former to survive during diabetes development. Understanding these differences may allow the design of strategies to protect beta cells and slow down the development of the disease. In addition, this research team is interested in identifying and testing chemicals that, by interacting with proteins involved in different signaling pathways (e.g., type I interferon pathway), can promote the survival of human pancreatic beta cells. These drugs would be a promising adjuvant therapy in the treatment of type 1 diabetes.<\/p>\n

https:\/\/isletbiologylab.umh.es\/\u00a0<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Laura Marroqu\u00ed” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Laura-Marroqui.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-laura-marroqui\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Cristina Ripoll” position=”Investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Cristina-Ripoll.png” _builder_version=”4.16″ header_text_color=”#000000″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-cristina-ripoll\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” locked=”off” global_colors_info=”{}”]<\/p>\n

Other collaborators of the group:<\/strong><\/p>\n

\u00a0Reinaldo Sousa Dos Santos\u00a0(FISABIO). ORCID:\u00a00000-0002-3219-4730<\/a>.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Diabetes Research (unibad)The Diabetes Research Unit is composed of three research groups and their research is focused on different aspects related to type 1, type 2 and gestational diabetes. https:\/\/diabetes.umh.es\/\u00a0Islet Cell Signaling LabWe work to understand how chemical pollutants influence glucose homeostasis. Our ultimate goal is to translate this knowledge into actions to decrease the […]<\/p>\n","protected":false},"author":23459,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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unidad de investigaci\u00f3n\u00a0<\/b><\/span>en Diabetes (UNIBAD)<\/strong><\/h1>

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La Unidad de Investigaci\u00f3n en Diabetes est\u00e1 compuesta por tres grupos de investigaci\u00f3n y su investigaci\u00f3n se centra en diferentes aspectos relacionados con la diabetes tipo 1, tipo 2 y gestacional.<\/span><\/p>

ISLET CELL SIGNALING LAB<\/strong><\/p>

Trabajamos para comprender c\u00f3mo los contaminantes qu\u00edmicos influyen en la homeostasis de la glucosa. Nuestro objetivo final es traducir este conocimiento en acciones para disminuir la prevalencia de la diabetes y los trastornos metab\u00f3licos relacionados.<\/span><\/p>

DIABESITY AND ISLET RESEARCH LAB<\/strong><\/p>

El Diabesity and Islet Research Lab se compromete a descubrir la fisiopatolog\u00eda de la diabetes mellitus gestacional y su importancia en el desarrollo posterior de la diabetes tipo 2, con especial \u00e9nfasis en la obesidad como factor de riesgo. Tambi\u00e9n estamos interesados \u200b\u200ben comprender mejor el papel de las sustancias qu\u00edmicas que alteran el metabolismo en la aparici\u00f3n de trastornos metab\u00f3licos. Nuestros estudios se centran principalmente en las c\u00e9lulas beta y alfa del p\u00e1ncreas, pero tambi\u00e9n en otros tejidos implicados en la homeostasis de la glucosa. El objetivo final es determinar nuevas dianas moleculares y contribuir al desarrollo de estrategias terap\u00e9uticas y de prevenci\u00f3n.<\/span><\/p>

ISLET BIOLOGY LAB<\/strong><\/p>

El principal inter\u00e9s de este grupo es comprender la funci\u00f3n de los islotes pancre\u00e1ticos y la supervivencia en salud y diabetes. El objetivo es comprender las diferencias moleculares entre las c\u00e9lulas alfa y beta que permiten a las primeras sobrevivir durante el desarrollo de la diabetes. Comprender estas diferencias puede permitir el dise\u00f1o de estrategias para proteger las c\u00e9lulas beta y ralentizar el desarrollo de la enfermedad. Adem\u00e1s, este equipo de investigaci\u00f3n est\u00e1 interesado en identificar y probar sustancias qu\u00edmicas que, al interactuar con prote\u00ednas involucradas en diferentes v\u00edas de se\u00f1alizaci\u00f3n (por ejemplo, la v\u00eda del interfer\u00f3n tipo I), puedan promover la supervivencia de las c\u00e9lulas beta pancre\u00e1ticas humanas. Estos f\u00e1rmacos ser\u00edan una prometedora terapia adyuvante en el tratamiento de la diabetes tipo 1.<\/span><\/p>

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Nuestras principales l\u00edneas de investigaci\u00f3n<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#f05227\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#f05227\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Inmunofarmacolog\u00eda en enfermedades hep\u00e1ticas\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

El principal objetivo de esta l\u00ednea es la b\u00fasqueda e identificaci\u00f3n de mol\u00e9culas bioactivas con actividad sobre la homeostasis energ\u00e9tica y que mejoren las alteraciones relacionadas con los trastornos metab\u00f3licos y la obesidad Para ello, trabajamos mediante la modulaci\u00f3n de las rutas metab\u00f3licas implicadas en el control energ\u00e9tico de la c\u00e9lula, la inducci\u00f3n del pardeamiento del tejido adiposo y la activaci\u00f3n de la termog\u00e9nesis. Por otro lado, las t\u00e9cnicas <\/span>in silico, <\/span><\/i>con el apoyo del uso de l\u00edneas celulares de pre-adipocitos, nos permiten buscar y evaluar la capacidad de activar dianas moleculares espec\u00edficas, as\u00ed como sus efectos sobre el metabolismo lip\u00eddico y los fen\u00f3menos de glucolipotoxicidad inducida. Los resultados de esta l\u00ednea de investigaci\u00f3n proporcionan candidatos potenciales para la elaboraci\u00f3n de nuevos productos nutrac\u00e9uticos con aplicaciones para el control del metabolismo energ\u00e9tico, el apetito y la plasticidad del tejido adiposo como estrategias para luchar contra la obesidad.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Inmunolog\u00eda del carcinoma hepatocelular (HCC)\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Estamos interesados en los mecanismos por los cuales el sistema inmunitario puede tanto promover como combatir los tumores y c\u00f3mo este conocimiento puede ser trasladado al desarrollo de terapias para tratar o prevenir el c\u00e1ncer. En particular, nuestros proyectos actuales estudian (1) el papel del complejo conocido como \u2018<\/span>inflamasoma<\/span><\/i>\u2019 durante la inflamaci\u00f3n hep\u00e1tica cr\u00f3nica y HCC, y (2) el impacto de los linfocitos CD4+ Th17 en el desarrollo de HCC y en la eficacia de la terapia de puntos de control inmunol\u00f3gico (<\/span>immune checkpoint inhibition<\/span><\/i>) <\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Equipo<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/veronica-ruiz.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"|29px|14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Jos\u00e9 Manuel Gonz\u00e1lez-Navajas<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Beatriz Lozano-Ruiz<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Pedro Zapater<\/b><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"1px||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Estudiantes postdoctorales<\/span><\/strong><\/span><\/h2>

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Susana Almenara<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/noelia-sanchez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Amalia Tzoumpa<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/noelia-sanchez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Huang Yin<\/b><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||11px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Publicaciones <\/span>representativas<\/span><\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#000000\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ffffff\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_text_color=\"#000000\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" custom_padding=\"12px||||false|false\" border_width_all=\"3px\" border_color_all=\"#ab1a2d\" box_shadow_style=\"preset3\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Functionality of beta-adrenergic receptors in patients with cirrhosis treated chronically with non-selective beta-blockers\" closed_toggle_text_color=\"#000000\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_color=\"#ffffff\" background_enable_color=\"on\" border_width_top=\"3px\" toggle_level=\"h5\" toggle_font=\"|600|||||||\" toggle_font_size=\"20px\" open=\"off\"]<\/p>

Almenara S, Lozano B, Gimenez P, Herrera I, Miralles C, Bellot P, Rodr\u00edguez M, Franc\u00e9s R, Gonzalez-Navajas JM, Pascual S, Zapater P. Functionality of beta-adrenergic receptors in patients with cirrhosis treated chronically with non-selective beta-blockers. Hepatol Int. 2020 Sep;14(5):858-868. doi: 10.1007\/s12072-020-10083-5.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"AIM2 deficiency reduces the development of hepatocellular carcinoma in mice\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Mart\u00ednez-Cardona C, Lozano-Ruiz B, Bachiller V, Peir\u00f3 G, Algaba-Chueca F, G\u00f3mez-Hurtado I, Such J, Zapater P, Franc\u00e9s R, Gonz\u00e1lez-Navajas JM. AIM2 deficiency reduces the development of hepatocellular carcinoma in mice. Int J Cancer. 2018 Dec 1;143(11):2997-3007. doi: 10.1002\/ijc.31827.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Treatment with non-selective beta-blockers affects the systemic inflammatory response to bacterial DNA in patients with cirrosis\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Gimenez P, Garcia-Martinez I, Franc\u00e9s R, Gonzalez-Navajas JM, Mauri M, Alfayate R, Almenara S, Miralles C, Palazon JM, Carnicer F, Pascual S, Such J, Horga JF, Zapater P. Treatment with non-selective beta-blockers affects the systemic inflammatory response to bacterial DNA in patients with cirrosis. Liver Int. 2018 Dec;38(12):2219-2227. doi: 10.1111\/liv.13890.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

\u00c1lvarez-Mart\u00ednez, F. J., J. C. Rodr\u00edguez, et al. (2021). \"The antimicrobial capacity of Cistus salviifolius<\/i> and Punica granatum <\/i>plant extracts against clinical pathogens is related to their polyphenolic composition.\" Scientific Reports 11(1): 588. <\/span>https:\/\/doi.org\/10.1038\/s41598-020-80003-y<\/a><\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Lozano-Ruiz B, Bachiller V, Garc\u00eda-Mart\u00ednez I, Zapater P, G\u00f3mez-Hurtado I, Moratalla A, Gim\u00e9nez P, Bellot P, Franc\u00e9s R, Such J, Gonz\u00e1lez-Navajas JM. Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis. J Hepatol. 2015 Jan;62(1):64-71. doi: 10.1016\/j.jhep.2014.08.027.<\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_enable_color=\"off\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px|411px|-60px|auto|true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ab1a2d\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\" disabled=\"on\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\" %22A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.%22\" _builder_version=\"4.2.2\" background_color=\"rgba(0,0,0,0)\" background_enable_color=\"on\" background_enable_image=\"off\" link_option_url_new_window=\"on\" open=\"off\"]<\/p>

Ruiz-Torres, V., N. Forsythe, et al. (2021). \"A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.\" Frontiers in Pharmacology 12(261). <\/span>https:\/\/doi.org\/10.3389\/fphar.2021.625946<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\" %22The antimicrobial capacity of Cistus salviifolius and Punica granatum plant extracts against clinical pathogens is related to their polyphenolic composition.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

\u00c1lvarez-Mart\u00ednez, F. J., J. C. Rodr\u00edguez, et al. (2021). \"The antimicrobial capacity of <\/span>Cistus salviifolius<\/span><\/i> and <\/span>Punica granatum <\/span><\/i>plant extracts against clinical pathogens is related to their polyphenolic composition.\" Scientific Reports 11(1): 588. <\/span>https:\/\/doi.org\/10.1038\/s41598-020-80003-y<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

\u00c1lvarez-Mart\u00ednez, F. J., E. Barraj\u00f3n-Catal\u00e1n, et al. (2021). \"Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.\" Phytomedicine 90: 153626. <\/span>https:\/\/doi.org\/10.1016\/j.phymed.2021.153626<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

E. Barraj\u00f3n-Catal\u00e1n; F.J. \u00c1lvarez-Mart\u00ednez; F. Borr\u00e1s; D.P\u00e9rez; N. Herrero; J.J. Ruiz; V. Micol. Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops. Food Chemistry. 310 - 125818, pp.1 - 9. <\/span>https:\/\/doi.org\/10.1016\/j.foodchem.2019.125818<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Agull\u00f3-Chazarra, L., I. Borr\u00e1s-Linares, et al. (2020). \"Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.\" Antioxidants 9(5): 418. <\/span>https:\/\/doi.org\/10.3390\/antiox9050418<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers.%22 \" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

S\u00e1nchez-Marzo, N., A. P\u00e9rez-S\u00e1nchez, et al. (2019). \"Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers.\" International Journal of Molecular Sciences 20(9): 2148. <\/span>https:\/\/doi.org\/10.3390\/ijms20092148<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Effect of Metabolaid\u00ae on pre- and stage 1 hypertensive patients: A randomized controlled trial.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Boix-Castej\u00f3n, M., M. Herranz-L\u00f3pez, et al. (2021). \"Effect of Metabolaid<\/span>\u00ae<\/span> on pre- and stage 1 hypertensive patients: A randomized controlled trial.\" Journal of Functional Foods 84: 104583. <\/span>https:\/\/doi.org\/10.1016\/j.jff.2021.104583<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Herranz-L\u00f3pez, M., M. Olivares-Vicente, et al. (2020). \"Quercetin metabolites from <\/span>Hibiscus sabdariffa<\/span><\/i> contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro.\" Food and Chemical Toxicology 144: 111606. <\/span>https:\/\/doi.org\/10.1016\/j.fct.2020.111606<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

S\u00e1nchez-Marzo, N., A. P\u00e9rez-S\u00e1nchez, et al. (2020). \"Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model.\" Antioxidants 9(3): 255. <\/span>https:\/\/doi.org\/10.3390\/antiox9030255<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight\/obese subjects: A randomized controlled trial.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Herranz-L\u00f3pez, M., M. Olivares-Vicente, et al. (2019). \"Differential effects of a combination of Hibiscus sabdariffa and <\/span>Lippia citriodora<\/span><\/i> polyphenols in overweight\/obese subjects: A randomized controlled trial.\" Scientific Reports 9(1): 2999. <\/span>https:\/\/doi.org\/10.1038\/s41598-019-39159-5<\/span><\/a><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2005"}],"collection":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/users\/23459"}],"replies":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/comments?post=2005"}],"version-history":[{"count":0,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2005\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media?parent=2005"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}