{"id":2011,"date":"2023-07-04T09:11:09","date_gmt":"2023-07-04T09:11:09","guid":{"rendered":"https:\/\/newidibe.zeus.umh.es\/?page_id=2011"},"modified":"2025-10-13T08:46:09","modified_gmt":"2025-10-13T08:46:09","slug":"peripheral-neuropathies","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/peripheral-neuropathies\/","title":{"rendered":"Peripheral Neuropathies"},"content":{"rendered":"

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Peripheral Neuropathies<\/b><\/span><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”65px||5px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” custom_padding=”||21px|||” global_colors_info=”{}”]<\/p>\n

The main objective is to understand the mechanisms underlying sensitization of sensory neurons caused by some diseases or drugs. We focus mainly on three pathologies: (i) chronic migraine as a paradigm of chronic inflammatory pain that, in addition, shows a strong sexual dimorphism; (ii) chemotherapy-induced peripheral neuropathy as a model of neuropathic pain syndrome; and, (iii) psoriatic pruritus as a model of chronic pruritus. We aim to validate therapeutic targets to identify and develop drug candidates that restore neuronal sensitivity. Our proposal is to develop a human skin model innervated by bioprinting and transdifferentiation techniques and validate it as a preclinical model to reduce the use of animals in experimentation.<\/span><\/p>\n

Prometeo project: <\/b>https:\/\/www.trilogy-umh.es\/<\/a><\/a><\/span><\/span><\/p>\n

Frutalga project: <\/b>https:\/\/idibe.umh.es\/proyecto-frutalga\/<\/a><\/p>\n

Gioconda Project: <\/b><\/span><\/span>https:\/\/idibe.umh.es\/en\/giocondaproject\/<\/a>\u00a0<\/span><\/span><\/span><\/span><\/p>\n

REDAVIP Project: <\/b>https:\/\/cordis.europa.eu\/project\/id\/101146746\/es<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”4.16″ custom_padding=”||70px|||” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”11px||4px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ header_font_size=”55px” header_2_font=”|||||on|||” header_2_text_color=”#2f0ccc” header_2_font_size=”48px” global_colors_info=”{}”]<\/p>\n

Team<\/strong><\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Asia Fern\u00e1ndez” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Asia-Fernandez-Carvajal-240×300.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-asia-fernandez-carvajal\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Antonio Ferrer” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Antonio-Ferrer.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-antonio-ferrer-montiel\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Gregorio Fern\u00e1ndez” position=”Member” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Gregorio-Fernandez.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-gregorio-fernandez-ballester\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Mila Collados Rodr\u00edguez” position=”Member” image_url=”https:\/\/idibe.umh.es\/files\/2025\/03\/Mila-foto-web.png” _builder_version=”4.17.4″ _module_preset=”default” position_text_color=”#000000″ text_orientation=”center” min_height=”129.4px” custom_margin=”||40px|||” hover_enabled=”0″ global_colors_info=”{}” link_option_url=”https:\/\/idibe.umh.es\/en\/milacolladosrodriguez\/” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Peripheral NeuropathiesThe main objective is to understand the mechanisms underlying sensitization of sensory neurons caused by some diseases or drugs. We focus mainly on three pathologies: (i) chronic migraine as a paradigm of chronic inflammatory pain that, in addition, shows a strong sexual dimorphism; (ii) chemotherapy-induced peripheral neuropathy as a model of neuropathic pain syndrome; […]<\/p>\n","protected":false},"author":23459,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"1px||4px|||\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" text_font=\"|||on|||||\" header_font=\"|600|||||||\" header_font_size=\"45px\" custom_padding=\"||0px|||\"]<\/p>

Neuropat\u00edas\u00a0<\/b><\/span>perif\u00e9ricas<\/strong><\/h1>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"65px||5px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" text_text_color=\"#000000\" text_font_size=\"18px\" min_height=\"360.8px\" custom_padding=\"||21px|||\"]<\/p>

El objetivo principal es comprender los mecanismos que subyacen a la sensibilizaci\u00f3n de las neuronas sensoriales ocasionados por ciertas patolog\u00edas o f\u00e1rmacos. Nos centramos principalmente en tres patolog\u00edas: (i) la migra\u00f1a cr\u00f3nica como paradigma del dolor inflamatorio cr\u00f3nico que, adem\u00e1s, muestra un fuerte dimorfismo sexual; (ii) la neuropat\u00eda perif\u00e9rica inducida por quimioterapia como modelo de s\u00edndrome de dolor neurop\u00e1tico; y, (iii) el prurito psori\u00e1sico como modelo de prurito cr\u00f3nico. Pretendemos validar dianas terap\u00e9uticas para identificar y desarrollar candidatos a f\u00e1rmacos que restauren la sensibilidad neuronal. Nuestra propuesta es desarrollar un modelo de piel humana inervada mediante t\u00e9cnicas de bioimpresi\u00f3n y transdiferenciaci\u00f3n y validarlo como precl\u00ednico para disminuir el uso de animales en experimentaci\u00f3n.<\/span><\/p>

P\u00e1gina web:\u00a0<\/b>https:\/\/www.trilogy-umh.es\/<\/span><\/a><\/span><\/p>

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Trabajamos en dos l\u00edneas de investigaci\u00f3n distintas<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#AB1A2D\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#AB1A2D\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_level=\"h3\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Inflamaci\u00f3n, dolor y prurito cr\u00f3nicos. \" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Comprensi\u00f3n de la se\u00f1alizaci\u00f3n neuronal sensorial. Esta subl\u00ednea se centra en comprender los mecanismos que subyacen a la sensibilizaci\u00f3n proalg\u00e9sica de las neuronas sensoriales, as\u00ed como su desensibilizaci\u00f3n tras la resoluci\u00f3n de lesiones o enfermedades. Nuestra hip\u00f3tesis considera que la cronificaci\u00f3n resulta de una falta o resoluci\u00f3n defectuosa de la sensibilizaci\u00f3n neuronal. Estamos enfocados en tres patolog\u00edas: (i) migra\u00f1a cr\u00f3nica como paradigma de dolor inflamatorio cr\u00f3nico que adicionalmente muestra un fuerte dimorfismo sexual; (ii) neuropat\u00eda perif\u00e9rica inducida por quimioterapia como modelo de s\u00edndrome de dolor neurop\u00e1tico; y (iii) prurito psori\u00e1sico como modelo de prurito cr\u00f3nico. El aspecto com\u00fan de estas tres condiciones es la participaci\u00f3n del sistema sensorial perif\u00e9rico que se sensibiliza al aumentar su actividad electrog\u00e9nica. Nos centramos en el papel de los canales i\u00f3nicos implicados en la generaci\u00f3n de potenciales de acci\u00f3n y en su propagaci\u00f3n, es decir, canales termoTRP, canales Na, Kv y HCN. Adem\u00e1s, investigamos c\u00f3mo la actividad de estos canales se ve afectada por los agentes proalg\u00e9sicos. El objetivo de estos estudios es validar dianas terap\u00e9uticas que se utilizan posteriormente en nuestro programa de descubrimiento de f\u00e1rmacos para identificar y desarrollar f\u00e1rmacos candidatos que restauren la actividad del canal y la sensibilidad neuronal.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Dise\u00f1o de mol\u00e9culas bioactivas. \" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Descubrimiento de f\u00e1rmacos candidatos para la terapia nociceptiva de precisi\u00f3n. La identificaci\u00f3n y dise\u00f1o de mol\u00e9culas bioactivas para diferentes aplicaciones (antiinflamatorias, analg\u00e9sicas y antiprurito) se basa en primer lugar en una estrategia computacional que utiliza modelado molecular, acoplamiento y din\u00e1mica sobre las dianas terap\u00e9uticas validadas. Adem\u00e1s, el cribado in silico<\/em> tambi\u00e9n se aplica a bibliotecas virtuales compuestas por miles a millones de mol\u00e9culas de fuentes naturales y sint\u00e9ticas. Los compuestos de impacto se validan en ensayos de HTS y los compuestos l\u00edder se caracterizan farmacol\u00f3gicamente in vitro<\/em> e in vivo<\/em>. Los candidatos a f\u00e1rmacos seleccionados se licencian a empresas de biotecnolog\u00eda para el desarrollo cl\u00ednico y precl\u00ednico.<\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Equipo<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/veronica-ruiz.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"|29px|14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Gregorio Fernandez-Ballester <\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Asia Fernandez-Carvajal <\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Antonio Ferrer-Montiel <\/b><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||70px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Investigadores postdoctorales<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]David Caba\u00f1ero Ferri<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Ver\u00f3nica Rivero Hern\u00e1ndez<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||70px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

COLABORADORES EXTERNOS INTEGRADOS EN EL GRUPO<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Rosario Gonz\u00e1lez-Mu\u00f1iz. Instituto de Qu\u00edmica M\u00e9dica (IQM-CSIC)<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||70px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

ESTUDIANTES\u00a0DE DOCTORADO<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_4,1_4,1_4,1_4\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\" locked=\"off\"][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url=\"https:\/\/orcid.org\/0000-0002-7219-3863\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0001-8089-0696\" link_option_url_new_window=\"on\"]David Alarc\u00f3n Alarc\u00f3n<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url=\"https:\/\/orcid.org\/0000-0002-7219-3863\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0002-7219-3863\" link_option_url_new_window=\"on\"]Laura Butr\u00f3n Garc\u00eda<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/umh-laura-marroqui.png\" url=\"https:\/\/orcid.org\/0000-0002-1819-7978\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0002-1819-7978\" link_option_url_new_window=\"on\"]Jorge de Andr\u00e9s L\u00f3pez<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" link_option_url_new_window=\"on\"]Simona Giorgi<\/strong><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_4,1_4,1_4,1_4\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\" locked=\"off\"][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url=\"https:\/\/orcid.org\/0000-0002-7219-3863\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0001-8089-0696\" link_option_url_new_window=\"on\"]Alicia Medina Peris<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/umh-laura-marroqui.png\" url=\"https:\/\/orcid.org\/0000-0002-1819-7978\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0002-1819-7978\" link_option_url_new_window=\"on\"]Eva Mar\u00eda Villalba Riquelme<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" link_option_url_new_window=\"on\"]Luis G\u00f3mez Salinas<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Tecnicos<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/veronica-ruiz.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"|29px|14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Jos\u00e9 Manuel Serrano Garc\u00eda <\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Gema Osuna Tenorio<\/strong><\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]Irene Mudarra Fraguas<\/b><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_padding=\"80px||87px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" locked=\"off\"]<\/p>

Publicaciones <\/span>representativas<\/span><\/strong><\/h2>

[\/et_pb_text][et_pb_accordion open_toggle_text_color=\"#000000\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ffffff\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_text_color=\"#000000\" toggle_level=\"h3\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" custom_padding=\"12px||||false|false\" border_width_all=\"3px\" border_color_all=\"#ab1a2d\" box_shadow_style=\"preset3\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Butron L., Nikolaeva M., Gonz\u00e1lez-Rodr\u00edguez S.,Devesa I., Fern\u00e1ndez Ballester G., Genazzani A., Pirali T, Fern\u00e1ndez-Carvajal A., Ferrer-Montiel A.(2021) \" closed_toggle_text_color=\"#000000\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_color=\"#ffffff\" background_enable_color=\"on\" border_width_top=\"3px\" toggle_level=\"h5\" toggle_font=\"|600|||||||\" toggle_font_size=\"20px\" open=\"off\"]<\/p>

A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability. Scientific reports 2021 Jan 8;11(1):246. doi: 10.1038\/s41598-020-80725-z. .https:\/\/pubmed.ncbi.nlm.nih.gov\/33420359\/<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"V. Blair Journigan, D Alarcon Alarcon, Feng Z., Wang Y., Liang T., Dawley, D., A.R.M. Ruhul Amin, Montano C., Van Horn W., Xie X.-Q., Ferrer-Montiel A., Fern\u00e1ndez-Carvajal A.(2021). \" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Structural and in vitro functional characterization of a menthyl TRPM8 antagonist indicates species-dependent regulation. (2021) ACS Medicinal Chemistry Letters 12(5):758-767, DOI: 10.1021\/acsmedchemlett.1c00001.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Bonache MA, Llabr\u00e9s P., Mart\u00edn-Escura C., De la Torre-Mart\u00ednez R., Medina-Peris A., Butr\u00f3n L., G\u00f3mez-Monterrey I., Roa A., Fern\u00e1ndez-Ballester G., Ferrer-Montiel A., Fern\u00e1ndez-Carvajal A., Gonz\u00e1lez-Mu\u00f1iz R. (2021)\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" custom_padding=\"||||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Phenylalanine-derived \u03b2-Lactam TRPM8 modulators. Configuration effect on the antagonist activity. Int J Mol Sci. 2021 Feb 27;22(5):2370-2392. doi: 10.3390\/ijms22052370.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Butr\u00f3n D.; Zamora H., Devesa, I.; Trevi\u00f1o,M:A.; Abian O.; Vel\u00e1zquez-Campoy A., M. A. Bonache, L. Lagartera, M. Mart\u00edn-Mart\u00ednez, S. Gonz\u00e1lez-Rodr\u00edguez, A. Baamonde, A. Fern\u00e1ndez-Carvajal, A. V Ferrer-Montiel, M. A. Jim\u00e9nez, R. Gonzalez-Mu\u00f1iz.\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

DD04107-Derived neuronal exocytosis inhibitor peptides: evidences for synaptotagmin-1 as a putative target. Bioorganic Chemistry. 2021. 115 doi: 10.1016\/j.bioorg.2021.105231.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"V. Blair Journigan, Z. Feng, S. Rahman, Y. Wang, A.R.M. Ruhul Amin, C. E. Heffner, N. Bachtel, Siyi Wang, S. Gonzalez-Rodriguez, A. Fern\u00e1ndez-Carvajal, G. Fern\u00e1ndez-Ballester, J. K. Hilton, S. Sestile, D. A. Vazquez-Molina, J. K. Harper, W.D. Van Horn, A. Ferrer-Montiel, X.-Q. Xie ,T. Rahman (2020).\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Structure-based design of novel biphenyl amide antagonists of human Transient Receptor Potential Cation Channel Subfamily M Member 8 channels (TRPM8) with potential implications in the treatment of sensory neuropathies. ACS Chemical Neuroscience. 11:268-290. doi:10.1021\/acschemneuro.9b00404.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Bonache, M.A. Mart\u00edn-Escura, C., de la Torre Mart\u00ednez, R., Medina, A., Gonz\u00e1lez-Rodr\u00edguez, S., Francesch, A., Cuevas, C Roa A.M., Fern\u00e1ndez-Ballester, G., Ferrer-Montiel, A., Fern\u00e1ndez-Carvajal, A., Gonz\u00e1lez-Mu\u00f1iz, R. Highly functionalized \u03b2-lactams and 2-ketopiperazines as TRPM8 antagonists with antitumor and antiallodynic activity. (2020). \" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Sci Rep. 2020 Aug 25;10(1):14154. doi: 10.1038\/s41598-020-70691-x.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Fern\u00e1ndez-Ballester, G., Fern\u00e1ndez-Carvajal, A., Ferrer-Montiel, A. Targeting ion channels: in silico preclinical approaches and opportunities.\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Expert Opinion in Therapeutic Targets. 2020, 1-19. doi: 10.1080\/14728222.2020.1820987.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Fern\u00e1ndez-Carvajal, A., Gonzalez-Mu\u00f1iz, R., Fern\u00e1ndez-Ballester, G., Ferrer-Montiel, A. Investigational drugs in early phase clinical trials targeting thermotrp channels.\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Expert Opinion in Investigational Drugs. 2020, 1-14. doi: 10.1080\/13543784.2020.1825680.\u00a0<\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"0px||3px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" custom_padding=\"||10px|||\"]<\/p>

Patentes<\/b><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#AB1A2D\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#AB1A2D\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_level=\"h3\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Neuronal exocytosis inhibiting peptide and cosmetic composition and pharmaceutical composition containing the peptide.\" open_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ab1a2d\" _builder_version=\"4.2.2\" body_text_color=\"#ffffff\" background_color=\"#ab1a2d\" background_enable_color=\"on\" background_enable_image=\"off\" toggle_text_color=\"#ffffff\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Inventors: Ferrer-Montiel, A.V., Planells-Cases, R., Blanes-Mira, C., Llobregat, M., Fern\u00e1ndez-Ballester, G., Gil, A., Guti\u00e9rrez, L.M., Viniegra, S., Carbonell, T. y P\u00e9rez-Pay\u00e1, E. Number: WO0064932 (A1) \u2015 2000-11-02 (licensed). Country: Spain, ES19990000844 19990423\/\/ 9900844\/0 (Extended v\u00eda PCT\/ES00\/00058). International.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Compounds which inhibit muscle contraction.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: C. Carreno Serraima; A. Ferrer Montiel; N. Garcia Sanz; W. Van Den Nest; N. Alminana Domenech; J. Cebrian Puche; G. Fernandez Ballester. Number: WO2011009626 (A1) \u2015 2011-01-27. PCT: PCT\/EP2010\/004530 (licensed)<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"TRP-receptor-modulating peptides and uses thereof\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: A. Ferrer\u2011Montiel, A. Fern\u00e1ndez-Carvajal, G. Fernandez Ballester, J. M. Gonz\u00e1lez Ros, C. Belmonte Mart\u00ednez, F. Viana, A. Gomis, P. Valente; M. Camprub\u00ed-Robles; W. Van Den Nest; C. Carreno Serraima. Number: WO2012\/098281 A2 \u2015 2012-07-26 \/\/ WO2012098281 (A3) \u2015 2012-11-29<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"TRP receptor modulating compounds and their uses.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: A. Ferrer\u2011Montiel, A. Fern\u00e1ndez-Carvajal, G. Fernandez Ballester, J. M. Gonz\u00e1lez Ros, C. Belmonte Mart\u00ednez, F. Viana, A. Gomis, R.M. Planells-Cases, M. Vidal, J. Bujons, A. Messeguer. Number: WO2012\/136873 A2<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Compounds which inhibit neuronal exocytosis.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Ferrer Montiel, A.; Fernandez Ballester, G.; Garcia Anton, J.M.; Carreno Serraima, C.; Alminana Domenech, N., Delgado Gonzalez, R. Number: WO2013153196 (A1) \u2015 2013-10-17 \/\/ WO2013153192 (A1) \u2015 2013-10-17 \/\/ WO2013153191 (A1) \u2015 2013-10-17 \/\/ EP2649984 (A1) \u2015 2013-10-16.\u00a0 PCT: PCT\/EP2013\/057656; PCT\/EP2013\/057674; PCT\/EP2013\/057658.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Peptides and compositions for use in cosmetics and medicine.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Grau-Campistany, A.; Pastor, S.; Carulla, P.; Escudero, J.C.; Boras, J.; Ferrer Montiel, A.; Devesa Giner, I.; Fernandez Ballester, G. Numbers: 18382118.0-1112. Date of filing: 27.02.2018.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Peptides having inhibitory activity on neural exocytosis.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Mancini, F.; Devesa Giner, I., Ferrer Montiel, A.; Fernandez Ballester, G.; Mangano, G.; Bartella, C. Number: 18177586.7-1118. Date of filing: 13.06.2018<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Peptides having inhibitory activity on muscarinic receptor M3. \" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Mancini, F.; Devesa Giner, I., Ferrer Montiel, A.; Fernandez Ballester, G.; Mangano, G.; Bartella, C. Number: 18177587.5-1118. Date of filing: 13.06.2018<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Pharmaceutical composition for the treatment of epiphora.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventor: Carlos Belmonte Mart\u00ednez, Juana Gallar Martinez, Antonio Ferrer Montiel, Asia Fern\u00e1ndez Carvajal, Felix Viana de la Iglesia. PCT\/ES02011\/070627, WO2012\/032209 A2. (Licensed)<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"TRPM8 receptor agonist compounds and their applications.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Antonio Ferrer Montiel, Asia Fern\u00e1ndez Carvajal, Carlos Belmonte Mart\u00ednez, Juana Gallar Martinez, Roberto de la Torre, Armando Genazzani, Tron Giancesare\u00a0\u00a0 Valentina Mercalli. PCT\/ES2017\/070026. (Licensed)<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Heterocyclic compounds as TRPM8 channel antagonists and their uses.\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Gonzalez Mu\u00f1oz R., Perez de Vega M.J., Bonache M.A.; Ferrer Montiel A.,\u00a0\u00a0 Fern\u00e1ndez Carvajal A., de la Torre R. PCT\/ES2016\/070483, WO2017005950 A1. (Licensed)<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"TRPV1 modulator compounds\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Inventors: Devesa I., Genazzani A., Pirali T., Fern\u00e1ndez Carvajal A., Ferrer Montiel A. EP17382266.9. WO2018206742A1 (Licensed)<\/p>

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