{"id":2099,"date":"2023-07-10T07:32:09","date_gmt":"2023-07-10T07:32:09","guid":{"rendered":"https:\/\/newidibe.zeus.umh.es\/?page_id=2099"},"modified":"2025-10-13T08:47:44","modified_gmt":"2025-10-13T08:47:44","slug":"antiviral-strategies","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/antiviral-strategies\/","title":{"rendered":"Antiviral Strategies"},"content":{"rendered":"

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Antiviral STRATEGIES<\/b><\/span><\/h1>\n

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The Antiviral Strategies Unit is made up of various research groups that work from computing aspects to the development of DNA vaccines, and they do so both in viruses that affect humans, animals and aquaculture<\/p>\n

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ANTIVIRAL STRATEGIES IN AQUACULTURE<\/strong><\/b><\/span><\/h2>\n

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<\/strong><\/p>\n

This line of research focuses on the development of new molecules with antiviral activity, as well as vaccines that can prevent or reduce the infection load. They work with study models such as zebrafish, rainbow trout and sea bass. The viruses under investigation are pancreatic necrosis virus (IPNV), spring carp viraemia virus (SVCV), viral hemorrhagic septicemia virus (VHSV), nerve necrosis virus (NNV) and salmonid alphavirus (SAV2). A fundamental part of his research is to deepen the knowledge of the innate and adaptive immune response to viral infection by fish. The ultimate goal of the group is to develop tools for the control of viral outbreaks in Aquaculture, both prophylactic (vaccines) and therapeutic (antiviral).<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Luis P\u00e9rez” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Luis-Perez-240×300.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-luis-perez\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”M\u00aa del Mar Ortega-Villaiz\u00e1n” position=”Investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Maria-del-Mar-Ortega.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-ma-del-mar-ortega-villaizan\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” global_colors_info=”{}”]<\/p>\n

Other members of the group:<\/strong><\/strong><\/p>\n

\u00a0Yeray Kevin Cerpa Damas (predoc).\u00a0ORCID:\u00a0<\/span>0009-0009-0785-0415<\/a><\/p>\n

\u00a0Ainhoa G\u00f3mez Quintanilla (predoc).<\/p>\n

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ERYTHROCYTES IN ANTIVIRAL IMMUNOLOGY GROUP<\/strong><\/b><\/span><\/h2>\n

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<\/strong><\/p>\n

Fish erythrocytes have been recognized as an important cellular mediator in the antiviral immune response. This group has focused its research on the study of the response of fish erythrocytes to viruses, vaccines and antiviral therapeutics with the aim of identifying new prophylactic and\/or therapeutic targets that allow us to mitigate diseases caused by viruses in aquaculture.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”M\u00aa del Mar Ortega-Villaiz\u00e1n” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Maria-del-Mar-Ortega.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-ma-del-mar-ortega-villaizan\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” global_colors_info=”{}”]<\/p>\n

Other members of the group:<\/strong><\/strong><\/p>\n

Ver\u00f3nica Chico Gras (postdoc). ORCID:<\/span>\u00a0<\/span>0000-0001-6983-2786<\/a><\/p>\n

Jose Carlos Campos S\u00e1nchez (postdoc). ORCID: 0000-0003-0303-5412<\/a><\/p>\n

Maria Salvador Mira (predoc). ORCID:\u00a0<\/span>0000-0002-8877-2018<\/a><\/p>\n

Celia Garc\u00eda Quintanilla (predoc). ORCID:\u00a0<\/span>0009-0005-2461-5637<\/a><\/p>\n

Adri\u00e1n L\u00f3pez Murcia (predoc).\u00a0ORCID:\u00a0<\/span>0009-0002-0673-1069<\/a><\/p>\n

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More information:<\/strong>\u00a0<\/span>https:\/\/idibe.umh.es\/research\/red-blood-cells-antiviral-immunology\/<\/a><\/p>\n

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ANTIVIRAL STRATEGIES AGAINST VIRUSES ENVELOPED THROUGH BIOCOMPUTING: DENGUE, ZIKA AND SARS<\/strong><\/b><\/span><\/h2>\n

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\u00a0Our group is dedicated to the study of the structural proteins of the Dengue, Zika and SARS viruses with the aim of identifying their molecular mechanism and biological function, as well as the conformational changes that give rise to the fusion of the viral membranes and the host cell. To do this, we study the structure, conformation, and interactions between proteins and between proteins and membranes, both the plasma membrane and the late endosome, using high-resolution molecular dynamics, characterizing the biomolecular interactions in structural terms, studying the structure of the membranotropic segments and make a detailed study of the interaction, modulation and structure of these segments. At the same time, developing bioinformatics tools that, together with the studies described above, would allow us to find therapeutic targets and new state-of-the-art antivirals that will permit us to find leading compounds with which to improve combination therapies in order to fight against these diseases.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Jos\u00e9 Villala\u00edn” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Jose-Villalain.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-jose-villalain\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

PROTEIN ARQUITECTURE LAB<\/b><\/span><\/h2>\n

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<\/b><\/p>\n

The group\u00b4s expertise lies in the field of Protein Engineering by combining computational and experimental approaches for biochemical, biophysics and structural characterization of macromolecules and their interactions with proteins, peptides and small molecules of a different nature. The group aims to unravel the molecular mechanisms of key proteins involved in different signaling pathways, recognition and fusion processes applied to different areas of biotechnology. One of the main objectives of the group is the design of peptides and\/or small molecules with antiviral properties able to inhibit fusion processes and cell invasion. Besides that, the group is interested on protein folding and misfolding (amyloids) behind diseases.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Ana Mar\u00eda Fern\u00e1ndez” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Ana-Maria-Fernandez-Escamilla.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-ana-maria-fernandez-escamilla\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

VIRAL IMMUNOLOGY & THERAPEUTICS LABORATORY GROUP<\/strong><\/b><\/span><\/h2>\n

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<\/strong><\/p>\n

At the Viral Immunology & Therapeutics Laboratory we develop vaccines and biotechnological tools to predict and prevent infections of pathogenic viruses that lead to humans at different stages of development (during pregnancy, at birth, childhood, adulthood, and old age) or under circumstances special clinics (eg, organ transplant patients). For this, we use platforms based on nucleic acids (DNA and RNA) and new forms of data analysis such as machine learning that increase the possibilities for the application of new ideas in this field. Our current effort is focused on human herpesviruses and paediatric respiratory viruses. However, we are open to new lines of research in collaboration with other researchers, clinicians and the biopharmaceutical industry.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Pablo Garc\u00eda” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Pablo-Garcia-Valtanen.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-pablo-garcia-valtanen\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|off” _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

HEROIC, HERPESVIRUS OPTIMAL INTERVENTION FOR A CURE<\/strong><\/b><\/span><\/h2>\n

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Herpesviruses lack a definitive cure and are responsible for clinically relevant diseases worldwide. With the ultimate goal of completely eliminating viral genomes and curing persistent infections, my research focuses on discovering novel drugs that can enhance strategic endogenous defences against viral obstruction. We integrate cell culture and molecular virology techniques with bioinformatics to address fundamental host-virus interaction questions, generating opportunities for future translational outcomes that aim to improve the quality of life and ageing.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” disabled_on=”off|off|off” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Mila Collados Rodr\u00edguez” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2025\/03\/Mila-foto-web-255×300.png” _builder_version=”4.17.4″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/milacolladosrodriguez\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_gallery gallery_ids=”23614″ show_title_and_caption=”off” show_pagination=”off” _builder_version=”4.17.4″ _module_preset=”default” transform_scale=”64%|64%” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”4.16″ custom_padding=”7px||4px|||” disabled=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.4″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” global_colors_info=”{}”]<\/p>\n

Other members of the group:<\/strong><\/strong><\/p>\n

Mila Collados Rodriguez<\/a> (postdoc). ORCID: 0000-0002-2304-6402<\/a><\/p>\n

 <\/p>\n

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Antiviral STRATEGIESThe Antiviral Strategies Unit is made up of various research groups that work from computing aspects to the development of DNA vaccines, and they do so both in viruses that affect humans, animals and aquaculture  ANTIVIRAL STRATEGIES IN AQUACULTURE This line of research focuses on the development of new molecules with antiviral activity, as […]<\/p>\n","protected":false},"author":23459,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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UNIDAD ESTRATEGIAS\u00a0<\/b><\/span>ANTIVIRALES<\/strong><\/h1>

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La Unidad de Estrategias Antivirales est\u00e1 compuesta por diversos grupos de investigaci\u00f3n que trabajan desde aspectos computaciones al desarrollo de vacunas DNA y lo hacen tanto en virus que afectan a humanos como a animales y acuicultura.<\/p>

GRUPO ESTRATEGIAS ANTIVIRALES EN ACUICULTURA <\/strong><\/p>

Esta l\u00ednea de investigaci\u00f3n se centra en el desarrollo de nuevas mol\u00e9culas con actividad antiviral, as\u00ed como vacunas que pueden prevenir o reducir la carga infectiva. Trabajan con modelos de estudio como el pez cebra, la trucha arcoiris y la lubina. Los virus objeto de investigaci\u00f3n son el virus de la necrosis pancre\u00e1tica (IPNV), el virus de la viremia primaveral de la carpa (SVCV), el virus de la septicemia hemorr\u00e1gica v\u00edrica (VHSV), el virus de la necrosis nerviosa (NNV) y el alfavirus de salm\u00f3nidos (SAV2). Parte fundamental de sus investigaciones es profundizar en el conocimiento de la respuesta inmunitaria innata y adaptativa a la infecci\u00f3n viral por parte del pez. El objetivo final del grupo es desarrollar herramientas de control de brotes virales de impacto en Acuicultura, tanto como profil\u00e1cticos (vacunas) como terap\u00e9uticos (antiv\u00edricos).<\/p>

GRUPO ERITROCITOS EN INMUNOLOG\u00cdA ANTIVIRAL<\/strong><\/p>

Los eritrocitos de los peces han sido reconocidos como un importante mediador celular en la respuesta inmunitaria antiviral. El grupo ha focalizado su investigaci\u00f3n en el estudio de la respuesta de los eritrocitos de peces a virus, vacunas y terap\u00e9uticos antivirales con el objetivo de identificar nuevas dianas profil\u00e1cticas y\/o terap\u00e9uticas que nos permitan mitigar las enfermedades causadas por virus en acuicultura.<\/p>

ESTRATEGIAS ANTIVIRALES CONTRA VIRUS CON ENVUELTA MEDIANTE BIOCOMPUTACI\u00d3N: DENGUE, ZIKA Y SARS.<\/strong><\/p>

Nuestro grupo se dedica al estudio de las prote\u00ednas estructurales de los virus del Dengue, Zika y SARS con el objetivo de identificar su mecanismo molecular y funci\u00f3n biol\u00f3gica, as\u00ed como los cambios conformacionales que dan lugar a la fusi\u00f3n de las membranas del virus y de la c\u00e9lula hu\u00e9sped. Para ello estudiamos mediante din\u00e1mica molecular de alta resoluci\u00f3n la estructura, conformaci\u00f3n e interacciones entre las prote\u00ednas y entre las prote\u00ednas y las membranas, tanto de la membrana plasm\u00e1tica como del endosoma tard\u00edo, caracterizando las interacciones biomoleculares en t\u00e9rminos estructurales, estudiar la estructura de los segmentos membranotr\u00f3picos y hacer un estudio detallado de la interacci\u00f3n, modulaci\u00f3n y estructura de estos segmentos. Al mismo tiempo, desarrollar herramientas bioinform\u00e1ticas que, junto con los estudios anteriormente descritos, nos permitan encontrar dianas terap\u00e9uticas y nuevos antivirales de \u00faltima generaci\u00f3n que nos permitan encontrar compuestos l\u00edderes con los que mejorar terapias combinadas que nos permitan luchar contra estas enfermedades.<\/p>

LABORATORIO DE ARQUITECTURA DE PROTE\u00cdNAS<\/strong><\/p>

La experiencia del grupo se encuentra en el campo de la Ingenier\u00eda de Prote\u00ednas combinando enfoques computacionales y experimentales para la caracterizaci\u00f3n bioqu\u00edmica, biof\u00edsica y estructural de macromol\u00e9culas y sus interacciones con prote\u00ednas, p\u00e9ptidos y peque\u00f1as mol\u00e9culas de diferente naturaleza. El grupo tiene como objetivo desentra\u00f1ar los mecanismos moleculares de prote\u00ednas clave implicadas en diferentes v\u00edas de se\u00f1alizaci\u00f3n, reconocimiento y procesos de fusi\u00f3n aplicados a diferentes \u00e1reas de la biotecnolog\u00eda. Uno de los principales objetivos del grupo es el dise\u00f1o de p\u00e9ptidos y\/o peque\u00f1as mol\u00e9culas con propiedades antivirales capaces de inhibir procesos de fusi\u00f3n e invasi\u00f3n celular. Adem\u00e1s de eso, el grupo est\u00e1 interesado en el plegamiento y el mal plegamiento de prote\u00ednas (amiloides) detr\u00e1s de las enfermedades.<\/p>

GRUPO LABORATORIO DE INMUNOLOG\u00cdA Y TERAP\u00c9UTICA V\u00cdRICAS<\/strong><\/p>

En el Laboratorio de Inmunolog\u00eda y Terap\u00e9utica V\u00edricas desarrollamos vacunas y herramientas biotecnol\u00f3gicas para predecir y prevenir infecciones de virus pat\u00f3genos que afectan al ser humano en las diferentes etapas de desarrollo (durante el embarazo, al nacer, infancia, edad adulta y la vejez) o en circunstancias cl\u00ednicas especiales (p.ej., pacientes de trasplantes de \u00f3rganos). Para ello utilizamos plataformas basadas en los \u00e1cidos nucleicos (ADN y ARN) y nuevas formas de an\u00e1lisis de datos como el machine learning que aumentan las posibilidades para la aplicaci\u00f3n de nuevas ideas en este campo. Nuestro esfuerzo actual est\u00e1 focalizado en los herpesvirus humanos y virus respiratorios pedi\u00e1tricos. No obstante, estamos abiertos a nuevas l\u00edneas de investigaci\u00f3n en colaboraci\u00f3n con otros investigadores, cl\u00ednicos y la industria biofarmac\u00e9utica.<\/p>

[\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" disabled_on=\"on|on|on\" disabled=\"on\"]<\/p>

Nuestras principales l\u00edneas de investigaci\u00f3n<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#f05227\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#f05227\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Nuevos antivirales contra los virus del SARS, DENGUE y ZIKA mediante din\u00e1mica molecular y docking (Dr. J. Villala\u00edn)\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Los virus del SARS, Dengue y Zika penetran en las c\u00e9lulas fusionando las membranas de su envoltura con la membrana plasm\u00e1tica y con la membrana del endosoma. Para la fusi\u00f3n de las membranas, se requieren dos pasos esenciales: el reconocimiento del receptor en la c\u00e9lula y la fusi\u00f3n de las monocapas externas e internas de las membranas. Este \u00faltimo paso es uno de los puntos cruciales con los que se puede combatir la replicaci\u00f3n de los virus, ya que, si se inhibe la fusi\u00f3n, se puede bloquear la entrada y por tanto la replicaci\u00f3n del virus. Adem\u00e1s, el mecanismo de fusi\u00f3n est\u00e1 conservado entre todos estos virus con envuelta, lo que hace que la b\u00fasqueda de un inhibidor global sea completamente factible. Nuestro grupo tiene como objetivo identificar compuestos naturales y org\u00e1nicos como nuevos inhibidores virales seleccionados de distintas bibliotecas qu\u00edmicas a trav\u00e9s del acoplamiento (\"docking\") mol\u00e9cula-mol\u00e9cula y la din\u00e1mica molecular. Tambi\u00e9n estudiamos la interacci\u00f3n con sistemas de biomembrana modelo de p\u00e9ptidos obtenidos a partir de dominios espec\u00edficos pertenecientes a prote\u00ednas de fusi\u00f3n con el fin de buscar regiones inhibidoras de la fusi\u00f3n de membrana.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Estrategias profil\u00e1cticas y terap\u00e9uticas para enfermedades virales de peces (Dr. L. Perez and Dr. M.M. Ortega-Villaiz\u00e1n)\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Esta l\u00ednea de investigaci\u00f3n se centra en el desarrollo de nuevas mol\u00e9culas con actividad antiviral as\u00ed como vacunas que pueden prevenir o reducir la carga infectiva. Nuestros modelos de estudio son la trucha arcoiris y el pez cebra. Los virus objeto de investigaci\u00f3n son el virus de la necrosis pancre\u00e1tica (IPNV), el virus de la viremia primaveral de la carpa (SVCV) y el virus de la septicemia hemorr\u00e1gica v\u00edrica (VHSV). Parte fundamental de nuestras investigaciones es profundizar en el conocimiento de la respuesta inmunitaria innata y adaptativa a la infecci\u00f3n viral por parte del pez. Nuestro objetivo final es desarrollar herramientas de control de brotes virales de impacto en Acuicultura.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Eritrocitos en inmunolog\u00eda antiviral (Dr. Mar\u00eda del Mar Ortega-Villaiz\u00e1n)\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Los peces son el grupo de vertebrados filogen\u00e9ticamente m\u00e1s antiguo con un sistema inmunitario con claras similitudes con el de mam\u00edferos. Sin embargo, el conocimiento actual del sistema inmunitario de los peces parece carecer de la pieza clave para completar el puzzle. En un intento de resolver esta cuesti\u00f3n, nuestro grupo ha demostrado que los eritrocitos de la trucha arcoiris pueden responder a las infecciones v\u00edricas y a los ant\u00edgenos v\u00edricos, por s\u00ed mismos, con una respuesta inmune innata, mediante la producci\u00f3n de mol\u00e9culas antivirales y una comunicaci\u00f3n paracrina antiviral con otras c\u00e9lulas, as\u00ed como con una potencial respuesta inmune adaptativa, mediante el procesamiento y presentaci\u00f3n de ant\u00edgenos y la regulaci\u00f3n del sistema del complemento. Estos resultados contribuyen a abrir nuevas v\u00edas de investigaci\u00f3n en la b\u00fasqueda de profil\u00e1cticos o terap\u00e9uticos para tratar las principales infecciones v\u00edricas que afectan a la acuicultura.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Identificaci\u00f3n racional de biomol\u00e9culas y dise\u00f1o de ligandos pept\u00eddicos, dirigidos a macromol\u00e9culas de inter\u00e9s biotecnol\u00f3gico. Caracterizaci\u00f3n biof\u00edsica y bioqu\u00edmica de sus mecanismos de acci\u00f3n. (Dra. Ana M. Fern\u00e1ndez-Escamilla)\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Las prote\u00ednas son m\u00e1quinas nanomoleculares, din\u00e1micas que se encuentran en todos los sistemas vivos, adoptando distintas estructuras tridimensionales (3D) para realizar multitud de funciones biol\u00f3gicas. Los avances en biolog\u00eda molecular y biotecnolog\u00eda han mejorado nuestra comprensi\u00f3n de los principios b\u00e1sicos funcionales y arquitect\u00f3nicos de las prote\u00ednas, convirti\u00e9ndolas en candidatos atractivos como generadores de conceptos para el desarrollo tecnol\u00f3gico en biomedicina, bioingenier\u00eda y en las \u00e1reas m\u00e1s recientes de la nanociencia. En Ingenier\u00eda Biomolecular es de especial inter\u00e9s, la caracterizaci\u00f3n bioqu\u00edmica y biof\u00edsica de prote\u00ednas mediante m\u00e9todos termodin\u00e1micos, cin\u00e9ticos, espectrosc\u00f3picos y estructurales que nos permitan comprender mejor las reglas que rigen los procesos de inter\u00e9s y su grado de implicaci\u00f3n en dichos procesos. El objetivo principal de esta l\u00ednea de investigaci\u00f3n, es conocer la relaci\u00f3n entre estructura y funci\u00f3n (o disfunci\u00f3n) de las prote\u00ednas, as\u00ed como la identificaci\u00f3n de mol\u00e9culas peque\u00f1as y p\u00e9ptidos de dise\u00f1o con propiedades determinadas (antivirales \/ inhibidores). Todo ello es abordado desde diferentes \u00e1ngulos, empleando m\u00e9todos in silico (dise\u00f1o racional de prote\u00ednas, modelado de prote\u00ednas y acoplamiento molecular para la identificaci\u00f3n de nuevos compuestos activos) e in vitro, para la caracterizaci\u00f3n biof\u00edsica, bioqu\u00edmica y estructural de diversos prote\u00ednas recombinantes y su interacci\u00f3n con otras macromol\u00e9culas, biomol\u00e9culas y p\u00e9ptidos, mediante el uso de t\u00e9cnicas espectrosc\u00f3picas (dicro\u00edsmo circular, fluorescencia, dispersi\u00f3n din\u00e1mica de luz) y termodin\u00e1micas (DSC e ITC). Nuestros estudios se centran en las siguientes subl\u00edneas de investigaci\u00f3n: i) Virus del Zika y Dengue. Nuevos antivirales de acci\u00f3n directa mediante herramientas computacionales y experimentales. Se dise\u00f1aron varios p\u00e9ptidos, con potenciales propiedades antivirales, dirigidos a prote\u00ednas virales no estructurales y estructurales ii) Dise\u00f1o de p\u00e9ptidos orientados hacia una terapia antiviral basada en la combinaci\u00f3n de antivirales con diferentes mecanismos de acci\u00f3n (inhibici\u00f3n de MTAsa y Nsp 10) contra el Coronavirus Sars-Cov-2. Hemos dise\u00f1ado varios p\u00e9ptidos dirigidos principalmente a interaccionar con la prote\u00edna Nsp10 para evitar su funci\u00f3n. iii) Estabilidad, plegamiento y oligomerizaci\u00f3n de prote\u00ednas con el objetivo de determinar las bases moleculares de la contribuci\u00f3n de la agregaci\u00f3n en variantes con susceptibilidad a participar en enfermedades pri\u00f3nicas. Estamos estudiando varias variantes para determinar el papel de las mutaciones en el mecanismo de agregaci\u00f3n. iv) Regularizaci\u00f3n de la estructura tridimensional de prote\u00ednas y su efecto sobre la funci\u00f3n. Hemos aumentado la simetr\u00eda de una prote\u00edna y estudiado su efecto sobre el plegamiento y la tendencia a formar agregaciones de tipo amiloide.<\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" hover_enabled=\"0\"]<\/p>

Equipo Estrategias Antivirales en Acuicultura<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Luis P\u00e9rez\" position=\"Investigador Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Luis-Perez-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-luis-perez\/\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"M\u00aa del Mar Ortega\" position=\"Investigadora\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Maria-del-Mar-Ortega-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dra-ma-del-mar-ortega-villaizan\/\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" hover_enabled=\"0\"]<\/p>

Equipo Eritrocitos en Inmunolog\u00eda Antiviral<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"M\u00aa del Mar Ortega\" position=\"Investigadora principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Maria-del-Mar-Ortega-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dra-ma-del-mar-ortega-villaizan\/\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" hover_enabled=\"0\"]<\/p>

Equipo Contra Virus con Envuelta mediante Biocomputaci\u00f3n<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Jos\u00e9 Villala\u00edn\" position=\"Investigador Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Jose-Villalain-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-jose-villalain\/\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" hover_enabled=\"0\"]<\/p>

Equipo Laboratorio de Arquitectura de Prote\u00ednas<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Ana Mar\u00eda Fern\u00e1ndez\" position=\"Investigadora Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Ana-Maria-Fernandez-Escamilla-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dra-ana-maria-fernandez-escamilla\/\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" hover_enabled=\"0\"]<\/p>

Equipo Laboratorio de Inmunolog\u00eda y Terap\u00e9utica V\u00edricas<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Pablo Garc\u00eda\" position=\"Investigador Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Pablo-Garcia-Valtanen-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-pablo-garcia-valtanen\/\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Personal<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_4,1_4,1_4,1_4\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Vicente_Micol.jpg\" url=\"https:\/\/orcid.org\/0000-0001-8089-0696\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" _builder_version=\"4.2.2\" width=\"100%\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0001-8089-0696\" link_option_url_new_window=\"on\"]<\/p>

Ana Mar\u00eda Fern\u00e1ndez Escamilla<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/J_Antonio_Encinar.jpg\" url=\"https:\/\/orcid.org\/0000-0002-7219-3863\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0002-7219-3863\" link_option_url_new_window=\"on\"]<\/p>

Mar\u00eda del Mar Ortega-Villaiz\u00e1n Romo<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Enrique_Barrajon.jpg\" url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0002-1819-7978\" link_option_url_new_window=\"on\"]<\/p>

Luis Perez Garc\u00eda Esta\u00f1<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_4\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Enrique_Barrajon.jpg\" url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" url_new_window=\"on\" use_overlay=\"on\" overlay_icon_color=\"#ab1a2d\" hover_overlay_color=\"rgba(51,51,51,0.39)\" hover_icon=\"%%137%%\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/orcid.org\/0000-0001-8113-0795\" link_option_url_new_window=\"on\"]<\/p>

Jos\u00e9 Villala\u00edn Boull\u00f3n<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"3px||70px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" header_2_font_size_tablet=\"\" header_2_font_size_phone=\"40px\" header_2_font_size_last_edited=\"on|phone\"]<\/p>

Investigadores postdoctorales<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Ver\u00f3nica Chico Gras<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"1px||70px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" header_2_font_size_tablet=\"\" header_2_font_size_phone=\"40px\" header_2_font_size_last_edited=\"on|phone\"]<\/p>

Estudiantes de doctorado<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px|auto|1px|auto|false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Mar\u00eda E. Salvador Mira<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-teresa.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Celia Garc\u00eda Quintanilla<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"3px||11px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" header_2_font_size_tablet=\"\" header_2_font_size_phone=\"40px\" header_2_font_size_last_edited=\"on|phone\"]<\/p>

T\u00e9cnicos\u00a0<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px|auto|90px|auto|false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Efr\u00e9n Lucas Ma\u00f1ogil<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-teresa.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Remedios Torres<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" header_2_font_size_tablet=\"\" header_2_font_size_phone=\"40px\" header_2_font_size_last_edited=\"on|phone\"]<\/p>

Publicaciones <\/span>representativas<\/span><\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_padding=\"80px||87px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#000000\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ffffff\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_text_color=\"#000000\" toggle_level=\"h3\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" custom_padding=\"12px||||false|false\" border_width_all=\"3px\" border_color_all=\"#ab1a2d\" box_shadow_style=\"preset3\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"Induction of viral interference by IPNV-carrier cells on target cells: a cell co-culture study\" closed_toggle_text_color=\"#000000\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_color=\"#ffffff\" background_enable_color=\"on\" border_width_top=\"3px\" toggle_level=\"h5\" toggle_font=\"|600|||||||\" toggle_font_size=\"20px\" open=\"off\"]<\/p>

R. Parre\u00f1o, S. Torres, L. Almagro, M. Bell\u00f3-Perez, A. Estepa, L. Perez. Induction of viral interference by IPNV-carrier cells on target cells: a cell co-culture study. Fish Shellfish Immunol. (2016) 58: 483-489. doi: 10.1016\/j.fsi.2016.09.052.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Beta-glucan enhances the response to SVCV infection in zebrafish\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

R. M. Medina-Gali, M.M. Ortega-Villaizan, L. Mercado, B. Novoa, J. Coll, L. Perez. Beta-glucan enhances the response to SVCV infection in zebrafish. Dev. Comp. Immunol. (2018) 84: 307-314. doi: 10.1016\/j.dci.2018.02.019.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"25-Hydroxycholesterol in a complex biomembrane. Differences with cholesterol\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" custom_padding=\"||||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Galiano, V.,\u00a0 Villala\u00edn, J. 2020. 25-Hydroxycholesterol in a complex biomembrane. Differences with cholesterol. Biochim. Biophys. Acta Biomembranes. 1862(11):183413 doi: 10.1016\/j.bbamem.2020.183413.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Galiano, V., Encinar, J.A., Villala\u00edn, J.\u00a0 2020 . Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane. Journal Membrane Biology. 253(2):115-128. doi: 10.1007\/s00232-020-00106-5<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Identification of the phospholipid binding regions of the envelope E protein of flaviviruses by molecular dynamics\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Carpio, L.,\u00a0 Jos\u00e9 Villala\u00edn, J.\u00a0 2020 . Identification of the phospholipid binding regions of the envelope E protein of flaviviruses by molecular dynamics. Journal Biomolecular Struct Dyn. 38(17):5136-5147. doi: 10.1080\/07391102.2019.1697368.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Epigallocatechin-3-gallate Location and Interaction with Late Endosomal and Plasma Membrane Model Membranes\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Villala\u00edn J.\u00a0 2018 . Epigallocatechin-3-gallate Location and Interaction with Late Endosomal and Plasma Membrane Model Membranes by Molecular Dynamics.<\/span><\/p>

J Biomol Struct Dyn. 2019 37:3122-3134.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Spontaneous membrane insertion of a Dengue virus NS2A peptide\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fajardo-S\u00e1nchez, E., Galiano V, Villala\u00edn J.\u00a0 2017. Spontaneous membrane insertion of a Dengue virus NS2A peptide. Archives Biochem. Biophys. 627: 56-66.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Fish red blood cells modulate immune genes in response to bacterial inclusion bodies made of TNF\u03b1 and a g-VHSV fragment\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Puente-Marin S.; Thwaite R.; Mercado L.; Coll J.; Roher N.; Ortega-Villaizan M. Fish red blood cells modulate immune genes in response to bacterial inclusion bodies made of TNF\u03b1 and a g-VHSV fragment. Frontiers in Immunology. 10, 2019.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"IFIT5 participates in the antiviral mechanisms of rainbow trout red blood cells\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Chico V.; Salvador-Mira M.; Nombela I.; Puente-Marin S.; Ciordia S.; Mena M.; Perez L.; Coll J.; Guzman F.; Encinar J.; Mercado L.; Ortega-Villaizan M. IFIT5 participates in the antiviral mechanisms of rainbow trout red blood cells. Frontiers in Immunology. 10, 2019.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell markers\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Nombela I; Requena-Platek R; Morales-Lange B; Chico V; Puente-Marin S; Ciordia S; Mena MC; Coll J; Perez L; Mercado L; Ortega-Villaizan M. Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell markers. Cells. 8, 2019.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Nucleated red blood cells: immune cell mediators of the antiviral response\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Nombela I; Ortega-Villaizan M. Nucleated red blood cells: immune cell mediators of the antiviral response. PLOS Pathogens. 14 - 4, pp. e1006910. 2018.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Molecular Binding Mechanism of TtgR Repressor to Antibiotics and Antimicrobials\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fernandez-Escamilla AM, Fernandez-Ballester G, Morel B, Casares-Atienza S, Ramos JL. (2015). Molecular Binding Mechanism of TtgR Repressor to Antibiotics and Antimicrobials. PLoS One 30;10(9):e0138469. doi: 10.1371\/journal.pone.0138469.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Engineering Biological Approaches for Detection of Toxic Compounds: A New Microbial Biosensor Based on the Pseudomonas putida TtgR Repressor\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Espinosa-Urgel M, Serrano L, Ramos JL, Fern\u00e1ndez-Escamilla AM. (2015) Engineering Biological Approaches for Detection of Toxic Compounds: A New Microbial Biosensor Based on the Pseudomonas putida TtgR Repressor. Mol Biotechnol. 57(6):558-64. doi: 10.1007\/s12033-015-9849-2.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Design and NMR conformational study of a beta-sheet peptide based on Betanova and WW domains\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fern\u00e1ndez-Escamilla AM, Ventura S, Serrano L, Jim\u00e9nez MA. (2006). Design and NMR conformational study of a beta-sheet peptide based on Betanova and WW domains. Protein Sci. 15(10):2278-89. doi: 10.1110\/ps.062186506.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-32px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fernandez-Escamilla AM, Rousseau F, Schymkowitz J, Serrano L. (2004). Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol. 2004 Oct;22(10):1302-6. doi: 10.1038\/nbt1012.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Solvation in protein folding analysis, combination of theoretical and experimental approaches\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fern\u00e1ndez-Escamilla AM, Cheung MS, Vega MC, Wilmanns M, Onuchic JN, Serrano L. (2004). Solvation in protein folding analysis, combination of theoretical and experimental approaches. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2834-9. doi: 10.1073\/pnas.0304180101.<\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_enable_color=\"off\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px|411px|-60px|auto|true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ab1a2d\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\" disabled=\"on\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\" %22A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.%22\" _builder_version=\"4.2.2\" background_color=\"rgba(0,0,0,0)\" background_enable_color=\"on\" background_enable_image=\"off\" link_option_url_new_window=\"on\" open=\"off\"]<\/p>

Ruiz-Torres, V., N. Forsythe, et al. (2021). \"A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.\" Frontiers in Pharmacology 12(261). <\/span>https:\/\/doi.org\/10.3389\/fphar.2021.625946<\/span><\/a><\/p>

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\u00c1lvarez-Mart\u00ednez, F. J., J. C. Rodr\u00edguez, et al. (2021). \"The antimicrobial capacity of <\/span>Cistus salviifolius<\/span><\/i> and <\/span>Punica granatum <\/span><\/i>plant extracts against clinical pathogens is related to their polyphenolic composition.\" Scientific Reports 11(1): 588. <\/span>https:\/\/doi.org\/10.1038\/s41598-020-80003-y<\/span><\/a><\/p>

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\u00c1lvarez-Mart\u00ednez, F. J., E. Barraj\u00f3n-Catal\u00e1n, et al. (2021). \"Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.\" Phytomedicine 90: 153626. <\/span>https:\/\/doi.org\/10.1016\/j.phymed.2021.153626<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

E. Barraj\u00f3n-Catal\u00e1n; F.J. \u00c1lvarez-Mart\u00ednez; F. Borr\u00e1s; D.P\u00e9rez; N. Herrero; J.J. Ruiz; V. Micol. Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops. Food Chemistry. 310 - 125818, pp.1 - 9. <\/span>https:\/\/doi.org\/10.1016\/j.foodchem.2019.125818<\/span><\/a><\/p>

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Agull\u00f3-Chazarra, L., I. Borr\u00e1s-Linares, et al. (2020). \"Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.\" Antioxidants 9(5): 418. <\/span>https:\/\/doi.org\/10.3390\/antiox9050418<\/span><\/a><\/p>

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S\u00e1nchez-Marzo, N., A. P\u00e9rez-S\u00e1nchez, et al. (2019). \"Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers.\" International Journal of Molecular Sciences 20(9): 2148. <\/span>https:\/\/doi.org\/10.3390\/ijms20092148<\/span><\/a><\/p>

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Boix-Castej\u00f3n, M., M. Herranz-L\u00f3pez, et al. (2021). \"Effect of Metabolaid<\/span>\u00ae<\/span> on pre- and stage 1 hypertensive patients: A randomized controlled trial.\" Journal of Functional Foods 84: 104583. <\/span>https:\/\/doi.org\/10.1016\/j.jff.2021.104583<\/span><\/a><\/p>

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Herranz-L\u00f3pez, M., M. Olivares-Vicente, et al. (2020). \"Quercetin metabolites from <\/span>Hibiscus sabdariffa<\/span><\/i> contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro.\" Food and Chemical Toxicology 144: 111606. <\/span>https:\/\/doi.org\/10.1016\/j.fct.2020.111606<\/span><\/a><\/p>

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S\u00e1nchez-Marzo, N., A. P\u00e9rez-S\u00e1nchez, et al. (2020). \"Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model.\" Antioxidants 9(3): 255. <\/span>https:\/\/doi.org\/10.3390\/antiox9030255<\/span><\/a><\/p>

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Herranz-L\u00f3pez, M., M. Olivares-Vicente, et al. (2019). \"Differential effects of a combination of Hibiscus sabdariffa and <\/span>Lippia citriodora<\/span><\/i> polyphenols in overweight\/obese subjects: A randomized controlled trial.\" Scientific Reports 9(1): 2999. <\/span>https:\/\/doi.org\/10.1038\/s41598-019-39159-5<\/span><\/a><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"80px||3px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\" custom_padding=\"||10px|||\"]<\/p>

Patentes<\/b><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled_on=\"on|on|on\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#f05227\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#f05227\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"IFIT5 para su uso como agente antiviral\" open_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ab1a2d\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_color=\"#ab1a2d\" background_enable_color=\"on\" background_enable_image=\"off\" toggle_text_color=\"#ffffff\" toggle_font=\"|700|||||||\" open=\"off\"]<\/p>

Inventors: M. Ortega-Villaiz\u00e1n, V. Chico, ME. Salvador. Number: P202031141. Countries: Spain.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"TANGO\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Es un algoritmo inform\u00e1tico dise\u00f1ado para predecir las regiones de nucleaci\u00f3n en prote\u00ednas durante el proceso de agregaci\u00f3n y la contribuci\u00f3n sobre la tendencia a agregar, de las mutaciones y las condiciones ambientales. Desarrollamos un algoritmo de mec\u00e1nica estad\u00edstica, TANGO, basado en principios f\u00edsico-qu\u00edmicos simples de formaci\u00f3n de estructuras secundarias extendidas asumiendo que las regiones centrales de un agregado, est\u00e1n completamente enterradas. Tango fue testado sobre 175 secuencias de 20 prote\u00ednas que hab\u00eda sido determinada, experimentalmente, su contribuci\u00f3n en la agregaci\u00f3n de prote\u00ednas. Adem\u00e1s, TANGO predice correctamente la tendencia a la agregaci\u00f3n de varias mutaciones relacionadas p\u00e9ptido-beta en la enfermedad del Alzheimer. Nuestro algoritmo, por lo tanto, abre la posibilidad de cribar grandes bases de datos en busca de motivos de agregaci\u00f3n potencialmente relacionados con enfermedades, as\u00ed como optimizar los rendimientos de prote\u00ednas recombinantes mediante el dise\u00f1o racional.<\/span><\/p>

TANGO fue concebido y desarrollado por Luis Serrano en el Laboratorio Europeo de Biolog\u00eda Molecular en Heidelberg.<\/span><\/p>

Testado, extracci\u00f3n de datos y aplicaciones por Ana-Maria Fernandez Escamilla, Frederic Rousseau y Joost Schymkowitz.<\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\"][et_pb_row _builder_version=\"4.2.2\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\"][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2099"}],"collection":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/users\/23459"}],"replies":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/comments?post=2099"}],"version-history":[{"count":0,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2099\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media?parent=2099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}