{"id":2108,"date":"2023-07-10T07:52:31","date_gmt":"2023-07-10T07:52:31","guid":{"rendered":"https:\/\/newidibe.zeus.umh.es\/?page_id=2108"},"modified":"2024-08-22T08:37:27","modified_gmt":"2024-08-22T08:37:27","slug":"hard-to-treat-cancers","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/hard-to-treat-cancers\/","title":{"rendered":"Hard to treat cancers"},"content":{"rendered":"

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Hard to treat<\/b><\/span>\u00a0cancers unit<\/strong><\/h1>\n

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The Hard-to-treat cancers unit is focus on the development of new tools in the area of cancer, especially in tumours as glioblastoma or pancreatic and breast cancer.<\/span><\/p>\n

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CHEMORESISTANCE AND CANCER GROUP<\/strong><\/b><\/span><\/h2>\n

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The “Chemoresistance and Cancer” group carries out its work through the search for new biomarkers and therapeutic targets of clinical utility for tumors with a poor prognosis, the screening and development of new therapeutic strategies for the treatment of glioblastoma, the delivery of antitumor agents in nanoformulations of different nature and the development of new cellular and animal models closer to the patient for the study of the molecular mechanisms involved in the acquisition of resistance to chemo and radiotherapy and the screening of new therapeutic strategies.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Miguel Saceda” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/07\/Miguel-Saceda-Sanchez-240×300.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-miguel-saceda\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

MOLECULAR NEUROBIOLOGY AND CANCER GROUP<\/strong><\/b><\/span><\/h2>\n

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<\/b><\/p>\n

The \u201cMolecular Neurobiology and Cancer\u201d group develops its study of glioblastoma (GBM), through three well-defined axes.
– Prevention- Diagnosis: Through the search for new biomarkers that can be identified fundamentally through liquid biopsies.
– Development of new therapies. This line is divided into the development of new drugs, for which metabolomic and transcriptomic analyzes are performed and molecular modeling techniques are used. The second part is the delivery of drugs, through the development of biomimetic nanoparticles and the use of small extracellular vesicles (EVs).
– Development of preclinical models. We work with organoid models and immunocompetent mice. On the other hand, a new GBM model in chicken has been developed.<\/p>\n

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RESEARCH GROUP ON GENETICS, EPIGENETICS AND TRANSCRIPTION IN NEUROPATHOLOGIES<\/strong><\/b><\/span><\/h2>\n

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This group is interested in the identification of new diagnostic tools in gliomas, including the especially aggressive glioblastoma, through the analysis of biomaterial (tissue, primary cultures) from patients: transcriptomics, epigenomics, correlates with clinical variables and possible implementations of artificial intelligence. From the therapeutic point of view, the group is interested in the mechanisms of action of drugs that modulate epigenetics.<\/span><\/p>\n

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Hard to treat\u00a0cancers unitThe Hard-to-treat cancers unit is focus on the development of new tools in the area of cancer, especially in tumours as glioblastoma or pancreatic and breast cancer.CHEMORESISTANCE AND CANCER GROUPThe “Chemoresistance and Cancer” group carries out its work through the search for new biomarkers and therapeutic targets of clinical utility for tumors […]<\/p>\n","protected":false},"author":23459,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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unidad de investigaci\u00f3n en C\u00e1nceres<\/b><\/span>\u00a0de Dif\u00edcil Tratamiento<\/strong><\/h1>

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La unidad de investigaci\u00f3n en C\u00e1nceres de dif\u00edcil tratamiento se centra en el desarrollo de nuevas herramientas en el \u00e1rea del c\u00e1ncer, especialmente en tumores como el glioblastoma o el c\u00e1ncer de p\u00e1ncreas y de mama.<\/p>

Grupo Quimorresistencia y C\u00e1ncer<\/strong><\/p>

El grupo \u201cQuimorresistencia y C\u00e1ncer\u201d realiza su labor en a trav\u00e9s de la b\u00fasqueda de nuevos biomarcadores y dianas terap\u00e9uticas de utilidad cl\u00ednica para tumores de mal pron\u00f3stico, el cribado y desarrollo de nuevas estrategias terap\u00e9uticas para el tratamiento del glioblastoma, la vehiculizaci\u00f3n de antitumorales en nanoformulaciones de distintas naturaleza y el desarrollo de nuevos modelos celulares y animales m\u00e1s cercanos al paciente para estudio de los mecanismos moleculares implicados en la adquisici\u00f3n de resistencia a la quimio y radioterapia y el cribado de nuevas estrategias terap\u00e9uticas.<\/p>

Grupo Neurobiolog\u00eda Molecular y C\u00e1ncer<\/strong><\/p>

El grupo de \u201cNeurobiolog\u00eda Molecular y C\u00e1ncer\u201d desarrolla su estudio del glioblastoma (GBM), a trav\u00e9s de tres ejes bien definidos.
- Prevenci\u00f3n- Diagn\u00f3stico: Mediante la b\u00fasqueda de nuevos biomarcadores que puedan ser identificados fundamentalmente a trav\u00e9s de biopsias l\u00edquidas.
- Desarrollo de nuevas terapias. Esta l\u00ednea se divide en el desarrollo de nuevos f\u00e1rmacos, para lo cual se realizan an\u00e1lisis metabol\u00f3micos, transcript\u00f3micos y se utilizan t\u00e9cnicas de modelado molecular. La segunda parte es la vehiculizaci\u00f3n de f\u00e1rmacos, mediante el desarrollo de nanopart\u00edculas biomim\u00e9ticas y el uso de ves\u00edculas extracelulares peque\u00f1as (EVs).
- Desarrollo de modelos precl\u00ednicos. Se trabaja con modelos de organoides y ratones inmunocompetentes. Por otro lado, se ha desarrollado un nuevo modelo de GBM en pollo.<\/p>

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Nuestras principales l\u00edneas de investigaci\u00f3n<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#f05227\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#f05227\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"B\u00fasqueda de tratamientos alternativos en tumores que hayan adquirido resistencia a tratamientos antineopl\u00e1sticos\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

En esta l\u00ednea de investigaci\u00f3n nos centramos en los tumores de mal pron\u00f3stico y alta resistencia a los tratamientos oncol\u00f3gicos, principalmente carcinoma pancre\u00e1tico exocrino, glioblastoma y carcinoma de colon. Para encontrar y probar nuevas alternativas terap\u00e9uticas, trabajamos en las siguientes \u00e1reas:<\/span><\/p>

- Investigar los mecanismos moleculares responsables de la resistencia a la quimioterapia y radioterapia en estos tumores con el fin de recuperar la sensibilidad al tratamiento.<\/span><\/p>

- Buscar biomarcadores y nuevas aproximaciones terap\u00e9uticas para este tipo de tumores a partir del an\u00e1lisis diferencial de la expresi\u00f3n g\u00e9nica.<\/p>

- Probar nuevos enfoques terap\u00e9uticos basados en el conocimiento de la transducci\u00f3n de se\u00f1ales y el control epigen\u00e9tico adquiridos en estos tumores o mediante nuevos tratamientos enzim\u00e1ticos.<\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Modelado molecular y dise\u00f1o de nanotransportadores para la administraci\u00f3n de f\u00e1rmacos para mejorar el tratamiento del c\u00e1ncer\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

En esta l\u00ednea de investigaci\u00f3n, intentamos mejorar los diferentes abordajes terap\u00e9uticos para tumores de mal pron\u00f3stico como el carcinoma de p\u00e1ncreas y el glioblastoma, aplicando las nuevas t\u00e9cnicas en modelado molecular y de liberaci\u00f3n de f\u00e1rmacos mediante nanopart\u00edculas de diferente naturaleza. Estamos trabajando espec\u00edficamente en esta \u00e1rea en los siguientes enfoques:<\/span><\/p>

- Modelado molecular, an\u00e1lisis y dise\u00f1o de docking y cribado virtual para la obtenci\u00f3n de inhibidores de quinasas de nueva generaci\u00f3n implicados en la transducci\u00f3n de se\u00f1ales. Estos inhibidores no se dirigen al dominio de uni\u00f3n de ATP para aumentar su especificidad.<\/span><\/p>

- Uso de nanopart\u00edculas de diferente naturaleza para transportar una enzima que induzca el estr\u00e9s oxidativo y la muerte celular de las c\u00e9lulas tumorales.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Determinar el papel de la metilaci\u00f3n en l\u00edneas celulares de glioma humano\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Se ha demostrado que la actividad de la metiltransferasa es cr\u00edtica para la proliferaci\u00f3n del glioblastoma. Hemos visto que la inhibici\u00f3n qu\u00edmica (EPZ 015666) de la prote\u00edna arginina metiltransferasa 5 (PRMT5) inhibe significativamente la proliferaci\u00f3n de l\u00edneas celulares de glioblastoma derivado del paciente (GBM). Actualmente estamos buscando otros candidatos para nuestros experimentos <\/span>in vitro<\/span><\/i> e <\/span>in vivo<\/span><\/i>. Abordaremos si esta actividad de metiltransferasa regula los procesos celulares intr\u00ednsecos de relevancia para el c\u00e1ncer 1) muerte de c\u00e9lulas basales, 2) proliferaci\u00f3n, 3) migraci\u00f3n, 4) crecimiento independiente de la adhesi\u00f3n, 5) invasi\u00f3n de matrigel y 6) secreci\u00f3n de citocinas.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Investigar el papel de los exosomas y su carga en GBM\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

En esta l\u00ednea, se estudiar\u00e1n las caracter\u00edsticas de los exosomas de l\u00edneas celulares de GBM de origen humano con el fin de comprender no solo el papel que juegan los exosomas, sino tambi\u00e9n los mecanismos involucrados en la formaci\u00f3n del nicho premetast\u00e1sico, tropismo, colonizaci\u00f3n y recurrencia de tumores de GBM. Los exosomas pueden transportar ARN de una c\u00e9lula a otra provocando alteraciones en la expresi\u00f3n de prote\u00ednas en la c\u00e9lula receptora. Por lo tanto, los exosomas tambi\u00e9n pueden mediar la resistencia a la terapia mediante la administraci\u00f3n de prote\u00ednas que aumentan la supervivencia de las c\u00e9lulas tumorales y la reparaci\u00f3n del ADN, reduciendo las concentraciones de f\u00e1rmacos intracelulares o eliminando prote\u00ednas proapopt\u00f3ticas como las caspasas. Una mayor comprensi\u00f3n del papel de los exosomas y su contenido en la progresi\u00f3n de los tumores cerebrales contribuir\u00e1 al descubrimiento de nuevos diagn\u00f3sticos y terapias.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Citrulinaci\u00f3n en el cerebro\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Muchos estudios en otros tipos de c\u00e1ncer apuntan a la citrulinaci\u00f3n como una modificaci\u00f3n postraduccional importante involucrada en la regulaci\u00f3n g\u00e9nica, la apoptosis y la formaci\u00f3n de NET, lo que hace que los p\u00e9ptidos de citrulinaci\u00f3n sean objetivos atractivos para las vacunas contra el c\u00e1ncer. En el cerebro, PADI 2 y PADI4 est\u00e1n altamente expresados y han sido ampliamente estudiados en relaci\u00f3n con otras patolog\u00edas como la artritis reumatoide y la enfermedad de Alzheimer. Esta l\u00ednea de investigaci\u00f3n parte de la idea de que la citrulinaci\u00f3n puede estar jugando un papel importante en la progresi\u00f3n del glioblastoma y que los tratamientos que se han utilizado en otras patolog\u00edas y tipos de c\u00e1ncer tambi\u00e9n pueden ser efectivos en pacientes con glioblastoma y por lo tanto deben ser probados.<\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Equipo en Quimiorresistencia y C\u00e1ncer<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Miguel Saceda\" position=\"Investigador Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Angel-Nadal-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-miguel-saceda\/\" link_option_url_new_window=\"on\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Equipo en Neurobiolog\u00eda Molecular y C\u00e1ncer<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Camino de Juan\" position=\"Investigadora Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Camino-de-Juan-240x300.png\" _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-camino-de-juan-romero\/\" link_option_url_new_window=\"on\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Investigadores principales<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/veronica-ruiz.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"|29px|14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Dr. Miguel Saceda (FISABIO)<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Dr. Camino de Juan Romero (FISABIO)<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Dr. Pilar Garc\u00eda Morales (UMH)<\/b><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Investigadores postdoctorales<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Dr. Mar\u00eda Fuentes Baile<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"1px||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Estudiantes predoctorales<\/span><\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px|auto|90px|auto|false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Elisabeth P\u00e9rez Valenciano<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-teresa.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Salom\u00e9 Araujo Abad<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||11px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

T\u00e9cnicos\u00a0<\/strong><\/span><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px|auto|61px|auto|false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p>

Antonio Manresa Manresa<\/strong><\/span><\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p>

Publicaciones <\/span>representativas<\/span><\/strong><\/h2>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#000000\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ffffff\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_text_color=\"#000000\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" custom_margin=\"||||false|false\" custom_padding=\"12px||||false|false\" border_width_all=\"3px\" border_color_all=\"#ab1a2d\" box_shadow_style=\"preset3\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?\" closed_toggle_text_color=\"#000000\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_color=\"#ffffff\" background_enable_color=\"on\" border_width_top=\"3px\" toggle_level=\"h5\" toggle_font=\"|600|||||||\" toggle_font_size=\"20px\" open=\"off\"]<\/p>

Fuentes-Baile M, P\u00e9rez-Valenciano E, <\/span>Garc\u00eda-Morales P<\/b>, <\/span>de Juan Romero C<\/b>, Bello-Gil D, Barber\u00e1 VM, Rodr\u00edguez-Lescure \u00c1, Sanz JM, Alenda C, <\/span>Saceda M<\/b>. CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?<\/span><\/i> Int J Mol Sci<\/b>. 2021 Feb 2;22(3):1477. doi: 10.3390\/ijms22031477. PMID: 33540681; PMCID: PMC7867295.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fuentes-Baile M, Ventero MP, Encinar JA, <\/span>Garc\u00eda-Morales P<\/b>, Poveda-Deltell M, P\u00e9rez-Valenciano E, Barber\u00e1 VM, Gallego-Plazas J, Rodr\u00edguez-Lescure \u00c1, Mart\u00edn-Nieto J, <\/span>Saceda M.<\/b> Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines<\/span><\/i>. Cancers (Basel).<\/b> 2020 Dec 11;12(12):3717. doi: 10.3390\/cancers12123717. PMID: 33322337; PMCID: PMC7763458.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fuentes-Baile M, <\/span>Garc\u00eda-Morales P<\/b>, P\u00e9rez-Valenciano E, Ventero MP, Sanz JM, <\/span>de Juan Romero C<\/b>, Barber\u00e1 VM, Alenda C<\/span>, Saceda M<\/b>. <\/span>Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines<\/span><\/i>. <\/span>Int J Mol Sci<\/b>. 2020 Nov 12;21(22):8522. doi: 10.3390\/ijms21228522. PMID: 33198289; PMCID: PMC7697521.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Fuentes-Baile M, Bello-Gil D, P\u00e9rez-Valenciano E, Sanz JM, <\/span>Garc\u00eda-Morales P<\/b>, Maestro B, Ventero MP, Alenda C, Barber\u00e1 VM, <\/span>Saceda M<\/b>. <\/span>CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells<\/span><\/i>. <\/span>Biomolecules<\/b>. 2020 Feb 3;10(2):222. doi: 10.3390\/biom10020222. PMID: 32028649; PMCID: PMC7072168.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Ventero MP, Fuentes-Baile M, Quereda C, Perez-Valeciano E, Alenda C, <\/span>Garcia-Morales P<\/b>, Esposito D, Dorado P, Manuel Barbera V, <\/span>Saceda M<\/b>. <\/span>Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3<\/span><\/i>. <\/span>PLoS One<\/b>. 2019 Feb 27;14(2):e0212581. doi: 10.1371\/journal.pone.0212581. Erratum in: PLoS One. 2019 Apr 16;14(4):e0215714. PMID: 30811476; PMCID: PMC6392282.<\/span><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"The centrosome protein AKNA regulates neurogenesis via microtubule organization\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"||||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Camargo Ortega G*, Falk S*, Johansson PA*, Peyre E, Broix L, Sahu SK, Hirst W, Schlichthaerle T, <\/span>De Juan Romero C<\/b>, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Br\u00e4uninger M, Nguyen L, G\u00f6tz M. <\/span>The centrosome protein AKNA regulates neurogenesis via microtubule organization<\/span><\/i>. <\/span>Nature.<\/b> 2019 Mar;567(7746):113-117. doi: 10.1038\/s41586-019-0962-4. Epub 2019 Feb 20. PMID: 30787442. <\/span>(IF: 43.070 Q1).<\/b><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

C\u00e1rdenas A, Villalba A, <\/span>de Juan Romero C<\/b>, Pic\u00f3 E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V. <\/span>Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.<\/span><\/i> Cell.<\/b> 2018 Jul 26;174(3):590-606.e21. doi: 10.1016\/j.cell.2018.06.007. Epub 2018 Jun 28. PMID: 29961574<\/span>. (IF: 31.398 Q1)<\/b><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"PDGFR and IGF-1R Inhibitors Induce a G2\/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p>

Carrasco-Garcia E, Martinez-Lacaci I, Mayor-L\u00f3pez L, Tristante E, Carballo-Santana M, <\/span>Garc\u00eda-Morales P<\/b>, Ventero Martin MP, Fuentes-Baile M, Rodriguez-Lescure \u00c1, <\/span>Saceda M<\/b>. <\/span>PDGFR and IGF-1R Inhibitors Induce a G2\/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines.<\/span><\/i> Cells<\/b>. 2018 Sep 6;7(9):131. doi: 10.3390\/cells7090131. PMID: 30200644; PMCID: PMC6162497.<\/span><\/p>

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_enable_color=\"off\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px|411px|-60px|auto|true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ab1a2d\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\" disabled=\"on\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\" %22A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.%22\" _builder_version=\"4.2.2\" background_color=\"rgba(0,0,0,0)\" background_enable_color=\"on\" background_enable_image=\"off\" link_option_url_new_window=\"on\" open=\"off\"]<\/p>

Ruiz-Torres, V., N. Forsythe, et al. (2021). \"A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.\" Frontiers in Pharmacology 12(261). <\/span>https:\/\/doi.org\/10.3389\/fphar.2021.625946<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\" %22The antimicrobial capacity of Cistus salviifolius and Punica granatum plant extracts against clinical pathogens is related to their polyphenolic composition.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

\u00c1lvarez-Mart\u00ednez, F. J., J. C. Rodr\u00edguez, et al. (2021). \"The antimicrobial capacity of <\/span>Cistus salviifolius<\/span><\/i> and <\/span>Punica granatum <\/span><\/i>plant extracts against clinical pathogens is related to their polyphenolic composition.\" Scientific Reports 11(1): 588. <\/span>https:\/\/doi.org\/10.1038\/s41598-020-80003-y<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

\u00c1lvarez-Mart\u00ednez, F. J., E. Barraj\u00f3n-Catal\u00e1n, et al. (2021). \"Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.\" Phytomedicine 90: 153626. <\/span>https:\/\/doi.org\/10.1016\/j.phymed.2021.153626<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

E. Barraj\u00f3n-Catal\u00e1n; F.J. \u00c1lvarez-Mart\u00ednez; F. Borr\u00e1s; D.P\u00e9rez; N. Herrero; J.J. Ruiz; V. Micol. Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops. Food Chemistry. 310 - 125818, pp.1 - 9. <\/span>https:\/\/doi.org\/10.1016\/j.foodchem.2019.125818<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

Agull\u00f3-Chazarra, L., I. Borr\u00e1s-Linares, et al. (2020). \"Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.\" Antioxidants 9(5): 418. <\/span>https:\/\/doi.org\/10.3390\/antiox9050418<\/span><\/a><\/p>

[\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers.%22 \" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p>

S\u00e1nchez-Marzo, N., A. P\u00e9rez-S\u00e1nchez, et al. (2019). \"Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers.\" International Journal of Molecular Sciences 20(9): 2148. <\/span>https:\/\/doi.org\/10.3390\/ijms20092148<\/span><\/a><\/p>

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Boix-Castej\u00f3n, M., M. Herranz-L\u00f3pez, et al. (2021). \"Effect of Metabolaid<\/span>\u00ae<\/span> on pre- and stage 1 hypertensive patients: A randomized controlled trial.\" Journal of Functional Foods 84: 104583. <\/span>https:\/\/doi.org\/10.1016\/j.jff.2021.104583<\/span><\/a><\/p>

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Herranz-L\u00f3pez, M., M. Olivares-Vicente, et al. (2020). \"Quercetin metabolites from <\/span>Hibiscus sabdariffa<\/span><\/i> contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro.\" Food and Chemical Toxicology 144: 111606. <\/span>https:\/\/doi.org\/10.1016\/j.fct.2020.111606<\/span><\/a><\/p>

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S\u00e1nchez-Marzo, N., A. P\u00e9rez-S\u00e1nchez, et al. (2020). \"Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model.\" Antioxidants 9(3): 255. <\/span>https:\/\/doi.org\/10.3390\/antiox9030255<\/span><\/a><\/p>

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Herranz-L\u00f3pez, M., M. Olivares-Vicente, et al. (2019). \"Differential effects of a combination of Hibiscus sabdariffa and <\/span>Lippia citriodora<\/span><\/i> polyphenols in overweight\/obese subjects: A randomized controlled trial.\" Scientific Reports 9(1): 2999. <\/span>https:\/\/doi.org\/10.1038\/s41598-019-39159-5<\/span><\/a><\/p>

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