[et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”1px||4px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” global_colors_info=”{}”]<\/p>\n
The biological activity of biomolecules is based on their ability to recognize each other to form non-covalent reversible complexes. Each of the members of this unit pursues some of the objectives that support molecular recognition processes by addressing different problems of interactions between biomolecules with different degrees of complexity.<\/span><\/p>\n By exploring the mechanisms of how a recognition element (enzyme, protein, ion channel, etc.) can interact with macromolecules, molecules and ions we can develop, among others, platforms for biodetection (fluorescent sensors and biosensors) and biocatalysis, as well as controlled drug delivery systems.<\/span><\/p>\n The main research lines of the unit are:<\/span><\/p>\n – Synthesis, design and characterisation of metallic and hybrid nanoparticles used as carriers for biomolecules and drugs and their controlled release.<\/span><\/p>\n – Enzymes in hydrogels and non-conventional media as platforms for biodetection and biocatalysis: applications in biomedicine and environmental monitoring.<\/span><\/p>\n – Allosteric modulation of model ion channels and neuroreceptors: role of lipids and hydrophobic therapeutic drugs (AMODICHAN).<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” global_colors_info=”{}”]<\/p>\n The group explores the molecular interactions among different components (biomolecules, polymers, nanomaterials\/particles, etc.) within different environments (physiological media, deep eutectic solvents, etc.) in order to assemble them into devices and exploit their full potential in applications such as biosensing, controlled drug delivery or biomolecule storage.<\/p>\n Research Lines of the Group:<\/p>\n – Development of fluorescent platforms for biosensing applications.<\/p>\n – Development of hybrid nanomaterials for biomedicine and environmental applications.<\/p>\n – Characterization of biological systems in confined and non-conventional environments.<\/p>\n – Development of submicrometric particles with ultra-high loading capacity for long-term storage of labile biomacromolecules.<\/p>\n – Design of nanoparticles composites for the oral administration of insulin.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Carmen Reyes Mateo” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Reyes-Mateo-240×300.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-carmen-reyes-mateo\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Francisco Javier G\u00f3mez” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/09\/Javier-Gomez-240×300.png” _builder_version=”4.17.4″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-javier-gomez\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” title_text=”Javier Gomez” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ text_font=”|||on|||||” header_font=”|600|||||||” header_font_size=”45px” header_font_size_tablet=”” header_font_size_phone=”30px” header_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_text_color=”#000000″ text_font_size=”18px” text_orientation=”justified” global_colors_info=”{}”]<\/p>\n Ion channels are membrane proteins present in all living organisms. They are responsible for controlling the flow of ions in cell membranes and hence regulate a large number of physiological processes, from the movement of a flagellum to the secretion of hormones, genetic expression, control of homeostasis, electrical signaling between neurons etc In fact, the dysfunction of these proteins is related to many diseases such as migraine, epilepsy, long QT syndrome, Brugada syndrome, malignant hyperthermia, and myasthenia, among others. That is why these macromolecules are considered key targets to develop new drugs to modulate their function. However, the great variety of ion channels, both in terms of structure and function, necessitates a rational design of highly selective drugs. To achieve this, the structure of the ion channel to be treated must be known at the atomic level, as well as correlating its different structural domains with the function that the channel performs. In other words, structure-function relationships have to be established.<\/span><\/p>\n Main lines of research:<\/span><\/p>\n -Decipher the molecular bases of the inactivation of ion channels<\/span><\/p>\n –Characterize the allosteric communication between the gates of the ion channels, and evaluate the impact of diseases-related mutations.<\/span><\/span><\/p>\n -Establish the molecular bases of the modulation of lipids on ionic channels, and the possible interference of hydrophobic therapeutic drugs.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ use_custom_gutter=”on” disabled_on=”off|off|off” _builder_version=”4.16″ custom_margin=”0px||||false|false” custom_padding=”31px||2px||false|false” locked=”off” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Jos\u00e9 Antonio Poveda” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Jose-Antonio-Poveda.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-jose-antonio-poveda\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Jos\u00e9 Manuel Gonz\u00e1lez” position=”Principal investigator” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Jose-Manuel-Gonzalez-Ros.png” _builder_version=”4.16″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dr-jose-manuel-gonzalez-ros\/” link_option_url_new_window=”on” global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_team_member name=”Marcela Giudizi” position=”Member” image_url=”https:\/\/idibe.umh.es\/files\/2023\/03\/Marcela-Giudici.png” _builder_version=”4.17.4″ position_text_color=”#000000″ text_orientation=”center” link_option_url=”https:\/\/idibe.umh.es\/en\/dra-ana-marcela-giudici\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Biosensing and Biorecognition\u00a0The biological activity of biomolecules is based on their ability to recognize each other to form non-covalent reversible complexes. Each of the members of this unit pursues some of the objectives that support molecular recognition processes by addressing different problems of interactions between biomolecules with different degrees of complexity. By exploring the mechanisms […]<\/p>\n","protected":false},"author":23459,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" [et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" custom_padding=\"1px||4px|||\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" text_font=\"|||on|||||\" header_font=\"|600|||||||\" header_font_size=\"45px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" text_text_color=\"#000000\" text_font_size=\"18px\" text_orientation=\"justified\"]<\/p> La actividad biol\u00f3gica de las biomol\u00e9culas se basa en su capacidad de reconocerse entre s\u00ed para formar complejos reversibles no covalentes. Cada uno de los miembros de esta unidad persigue alguno de los objetivos que sustentan los procesos de reconocimiento molecular abordando diferentes problemas de interacciones entre biomol\u00e9culas con distintos grados de complejidad.<\/span><\/p> Explorando los mecanismos sobre c\u00f3mo un elemento de reconocimiento (enzima, prote\u00edna, canal i\u00f3nico, etc.) puede interactuar con macromol\u00e9culas, mol\u00e9culas e iones es posible desarrollar, entre otros, plataformas de biodetecci\u00f3n (sensores fluorescentes y biosensores) y biocat\u00e1lisis, as\u00ed como sistemas de administraci\u00f3n controlada de f\u00e1rmacos.<\/span><\/p> Las principales l\u00edneas de investigaci\u00f3n de la unidad son:<\/span><\/p> -S\u00edntesis, dise\u00f1o y caracterizaci\u00f3n de nanopart\u00edculas met\u00e1licas e h\u00edbridas utilizadas como transportadores de biomol\u00e9culas y f\u00e1rmacos y su liberaci\u00f3n controlada.<\/span><\/p> -Enzimas en hidrogeles y medios no convencionales como plataformas de biodetecci\u00f3n y biocat\u00e1lisis: aplicaciones en biomedicina y monitorizaci\u00f3n ambiental.<\/span><\/p> -Modulaci\u00f3n alost\u00e9rica de canales i\u00f3nicos modelo y neurorreceptores: papel de los l\u00edpidos y f\u00e1rmacos terap\u00e9uticos hidrof\u00f3bicos (AMODICHAN).<\/span><\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" text_font=\"|||on|||||\" header_font=\"|600|||||||\" header_font_size=\"45px\" header_font_size_tablet=\"\" header_font_size_phone=\"30px\" header_font_size_last_edited=\"on|phone\" locked=\"off\"]<\/p> [\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" text_text_color=\"#000000\" text_font_size=\"18px\" text_orientation=\"justified\"]<\/p> \u200bEl grupo explora las interacciones moleculares entre diferentes componentes (biomol\u00e9culas, pol\u00edmeros, nanomateriales\/part\u00edculas, etc.) en diferentes entornos (medios fisiol\u00f3gicos, disolventes eut\u00e9cticos profundos, etc.) para ensamblarlos en dispositivos y explotar todo su potencial en aplicaciones como como biodetecci\u00f3n, administraci\u00f3n controlada de f\u00e1rmacos o almacenamiento de biomol\u00e9culas.<\/span><\/p> L\u00edneas de Investigaci\u00f3n del Grupo:<\/span><\/p> - Desarrollo de plataformas fluorescentes para aplicaciones de biodetecci\u00f3n.<\/span><\/p> -Desarrollo de nanomateriales h\u00edbridos para aplicaciones biom\u00e9dicas y medioambientales.<\/span><\/p> -Caracterizaci\u00f3n de sistemas biol\u00f3gicos en ambientes confinados y no convencionales.<\/span><\/p> -Desarrollo de part\u00edculas submicrom\u00e9tricas con capacidad de carga ultra alta para el almacenamiento a largo plazo de biomacromol\u00e9culas l\u00e1biles.<\/span><\/p> -Dise\u00f1o de composites de nanopart\u00edculas para la administraci\u00f3n oral de insulina.<\/span><\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Carmen Reyes Mateo\" position=\"Investigadora Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Reyes-Mateo-240x300.png\" _builder_version=\"4.2.2\" position_text_color=\"#000000\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dra-carmen-reyes-mateo\/\" link_option_url_new_window=\"on\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Francisco Javier G\u00f3mez\" position=\"Investigador Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/02\/unnamed-225x300.png\" _builder_version=\"4.2.2\" position_text_color=\"#000000\" text_orientation=\"center\" link_option_url_new_window=\"on\" hover_enabled=\"0\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" text_font=\"|||on|||||\" header_font=\"|600|||||||\" header_font_size=\"45px\" header_font_size_tablet=\"\" header_font_size_phone=\"30px\" header_font_size_last_edited=\"on|phone\" locked=\"off\"]<\/p> [\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" text_text_color=\"#000000\" text_font_size=\"18px\" text_orientation=\"justified\"]<\/p> Los canales i\u00f3nicos son prote\u00ednas de membrana presentes en todos los organismos vivos. Se encargan de controlar el flujo de iones en las membranas celulares y de ah\u00ed que regulen una gran cantidad de procesos fisiol\u00f3gicos, desde el movimiento de un flagelo a la secreci\u00f3n de hormonas, la expresi\u00f3n gen\u00e9tica, el control de la homeostasis, la se\u00f1alizaci\u00f3n el\u00e9ctrica entre neuronas, etc. De hecho, la disfunci\u00f3n de estas prote\u00ednas est\u00e1 relacionada con muchas enfermedades como migra\u00f1a, epilepsia, s\u00edndrome QT largo, s\u00edndrome de Brugada, hipertermia maligna, y miastenia entre otros. Es por ello que estas macromol\u00e9culas son consideradas dianas clave para desarrollar nuevos f\u00e1rmacos para modular su funci\u00f3n. Sin embargo, la gran variedad de canales i\u00f3nicos, tanto en t\u00e9rminos de estructura como de funci\u00f3n, hacen necesario un dise\u00f1o racional de f\u00e1rmacos muy selectivos. Para conseguir eso, la estructura del canal i\u00f3nico a tratar ha de ser conocida a nivel at\u00f3mico, as\u00ed como correlacionar sus diferentes dominios estructurales con la funci\u00f3n que el canal desempe\u00f1a. En otras palabras, se han de establecer las relaciones estructura-funci\u00f3n.<\/span><\/p> Principales l\u00edneas de investigaci\u00f3n:<\/span><\/p> -Descifrar el mecanismo molecular.<\/span><\/p> -Descifrar las bases moleculares de la inactivaci\u00f3n de los canales i\u00f3nicos.<\/span><\/p> -Los canales i\u00f3nicos como prote\u00ednas de membrana.<\/span><\/p> -Muchos canales i\u00f3nicos est\u00e1n regulados mediante dos compuertas.<\/span><\/p> \u200b<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||2px||false|false\" locked=\"off\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Jos\u00e9 Antonio Poveda\" position=\"Investigadora Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Jose-Antonio-Poveda-240x300.png\" _builder_version=\"4.2.2\" position_text_color=\"#000000\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-jose-antonio-poveda\/\" link_option_url_new_window=\"on\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_team_member name=\"Jos\u00e9 Manuel Gonz\u00e1lez\" position=\"Investigadora Principal\" image_url=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Jose-Manuel-Gonzalez-Ros-240x300.png\" _builder_version=\"4.2.2\" position_text_color=\"#000000\" text_orientation=\"center\" link_option_url=\"https:\/\/newidibe.zeus.umh.es\/dr-jose-manuel-gonzalez-ros\/\" link_option_url_new_window=\"on\"][\/et_pb_team_member][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#f05227\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#f05227\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_color=\"#ab1a2d\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"B\u00fasqueda de tratamientos alternativos en tumores que hayan adquirido resistencia a tratamientos antineopl\u00e1sticos\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> En esta l\u00ednea de investigaci\u00f3n nos centramos en los tumores de mal pron\u00f3stico y alta resistencia a los tratamientos oncol\u00f3gicos, principalmente carcinoma pancre\u00e1tico exocrino, glioblastoma y carcinoma de colon. Para encontrar y probar nuevas alternativas terap\u00e9uticas, trabajamos en las siguientes \u00e1reas:<\/span><\/p> - Investigar los mecanismos moleculares responsables de la resistencia a la quimioterapia y radioterapia en estos tumores con el fin de recuperar la sensibilidad al tratamiento.<\/span><\/p> - Buscar biomarcadores y nuevas aproximaciones terap\u00e9uticas para este tipo de tumores a partir del an\u00e1lisis diferencial de la expresi\u00f3n g\u00e9nica.<\/p> - Probar nuevos enfoques terap\u00e9uticos basados en el conocimiento de la transducci\u00f3n de se\u00f1ales y el control epigen\u00e9tico adquiridos en estos tumores o mediante nuevos tratamientos enzim\u00e1ticos.<\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Modelado molecular y dise\u00f1o de nanotransportadores para la administraci\u00f3n de f\u00e1rmacos para mejorar el tratamiento del c\u00e1ncer\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> En esta l\u00ednea de investigaci\u00f3n, intentamos mejorar los diferentes abordajes terap\u00e9uticos para tumores de mal pron\u00f3stico como el carcinoma de p\u00e1ncreas y el glioblastoma, aplicando las nuevas t\u00e9cnicas en modelado molecular y de liberaci\u00f3n de f\u00e1rmacos mediante nanopart\u00edculas de diferente naturaleza. Estamos trabajando espec\u00edficamente en esta \u00e1rea en los siguientes enfoques:<\/span><\/p> - Modelado molecular, an\u00e1lisis y dise\u00f1o de docking y cribado virtual para la obtenci\u00f3n de inhibidores de quinasas de nueva generaci\u00f3n implicados en la transducci\u00f3n de se\u00f1ales. Estos inhibidores no se dirigen al dominio de uni\u00f3n de ATP para aumentar su especificidad.<\/span><\/p> - Uso de nanopart\u00edculas de diferente naturaleza para transportar una enzima que induzca el estr\u00e9s oxidativo y la muerte celular de las c\u00e9lulas tumorales.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Determinar el papel de la metilaci\u00f3n en l\u00edneas celulares de glioma humano\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> Se ha demostrado que la actividad de la metiltransferasa es cr\u00edtica para la proliferaci\u00f3n del glioblastoma. Hemos visto que la inhibici\u00f3n qu\u00edmica (EPZ 015666) de la prote\u00edna arginina metiltransferasa 5 (PRMT5) inhibe significativamente la proliferaci\u00f3n de l\u00edneas celulares de glioblastoma derivado del paciente (GBM). Actualmente estamos buscando otros candidatos para nuestros experimentos <\/span>in vitro<\/span><\/i> e <\/span>in vivo<\/span><\/i>. Abordaremos si esta actividad de metiltransferasa regula los procesos celulares intr\u00ednsecos de relevancia para el c\u00e1ncer 1) muerte de c\u00e9lulas basales, 2) proliferaci\u00f3n, 3) migraci\u00f3n, 4) crecimiento independiente de la adhesi\u00f3n, 5) invasi\u00f3n de matrigel y 6) secreci\u00f3n de citocinas.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Investigar el papel de los exosomas y su carga en GBM\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> En esta l\u00ednea, se estudiar\u00e1n las caracter\u00edsticas de los exosomas de l\u00edneas celulares de GBM de origen humano con el fin de comprender no solo el papel que juegan los exosomas, sino tambi\u00e9n los mecanismos involucrados en la formaci\u00f3n del nicho premetast\u00e1sico, tropismo, colonizaci\u00f3n y recurrencia de tumores de GBM. Los exosomas pueden transportar ARN de una c\u00e9lula a otra provocando alteraciones en la expresi\u00f3n de prote\u00ednas en la c\u00e9lula receptora. Por lo tanto, los exosomas tambi\u00e9n pueden mediar la resistencia a la terapia mediante la administraci\u00f3n de prote\u00ednas que aumentan la supervivencia de las c\u00e9lulas tumorales y la reparaci\u00f3n del ADN, reduciendo las concentraciones de f\u00e1rmacos intracelulares o eliminando prote\u00ednas proapopt\u00f3ticas como las caspasas. Una mayor comprensi\u00f3n del papel de los exosomas y su contenido en la progresi\u00f3n de los tumores cerebrales contribuir\u00e1 al descubrimiento de nuevos diagn\u00f3sticos y terapias.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Citrulinaci\u00f3n en el cerebro\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> Muchos estudios en otros tipos de c\u00e1ncer apuntan a la citrulinaci\u00f3n como una modificaci\u00f3n postraduccional importante involucrada en la regulaci\u00f3n g\u00e9nica, la apoptosis y la formaci\u00f3n de NET, lo que hace que los p\u00e9ptidos de citrulinaci\u00f3n sean objetivos atractivos para las vacunas contra el c\u00e1ncer. En el cerebro, PADI 2 y PADI4 est\u00e1n altamente expresados y han sido ampliamente estudiados en relaci\u00f3n con otras patolog\u00edas como la artritis reumatoide y la enfermedad de Alzheimer. Esta l\u00ednea de investigaci\u00f3n parte de la idea de que la citrulinaci\u00f3n puede estar jugando un papel importante en la progresi\u00f3n del glioblastoma y que los tratamientos que se han utilizado en otras patolog\u00edas y tipos de c\u00e1ncer tambi\u00e9n pueden ser efectivos en pacientes con glioblastoma y por lo tanto deben ser probados.<\/span><\/p> [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled=\"on\" locked=\"off\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/veronica-ruiz.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"|29px|14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Dr. Miguel Saceda (FISABIO)<\/strong><\/span><\/p> [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Dr. Camino de Juan Romero (FISABIO)<\/strong><\/span><\/p> [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/marilo-olivare.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Dr. Pilar Garc\u00eda Morales (UMH)<\/b><\/span><\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px||||false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Dr. Mar\u00eda Fuentes Baile<\/strong><\/span><\/p> [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"1px||70px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px|auto|90px|auto|false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-losada.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Elisabeth P\u00e9rez Valenciano<\/strong><\/span><\/p> [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/maria-teresa.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|150px||150px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Salom\u00e9 Araujo Abad<\/strong><\/span><\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"3px||11px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,1_3,1_3\" use_custom_gutter=\"on\" _builder_version=\"4.2.2\" custom_margin=\"0px|auto|61px|auto|false|false\" custom_padding=\"31px||3px||false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/05\/Francisco-Alvarez.jpg\" url_new_window=\"on\" align=\"center\" force_fullwidth=\"on\" _builder_version=\"4.2.2\" module_alignment=\"center\" custom_margin=\"||14px|||\" custom_padding=\"|50px||50px|false|false\"][\/et_pb_image][et_pb_text _builder_version=\"4.2.2\" text_orientation=\"center\" link_option_url_new_window=\"on\"]<\/p> Antonio Manresa Manresa<\/strong><\/span><\/p> [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_3\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.2.2\" custom_padding=\"11px||4px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font_size=\"55px\" header_2_font=\"|||||on|||\" header_2_text_color=\"#2f0ccc\" header_2_font_size=\"48px\"]<\/p> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_margin=\"-60px||-60px||true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#000000\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ffffff\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" icon_font_size=\"32px\" _builder_version=\"4.2.2\" toggle_text_color=\"#000000\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" custom_margin=\"||||false|false\" custom_padding=\"12px||||false|false\" border_width_all=\"3px\" border_color_all=\"#ab1a2d\" box_shadow_style=\"preset3\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\"CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?\" closed_toggle_text_color=\"#000000\" icon_color=\"#ab1a2d\" use_icon_font_size=\"on\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_color=\"#ffffff\" background_enable_color=\"on\" border_width_top=\"3px\" toggle_level=\"h5\" toggle_font=\"|600|||||||\" toggle_font_size=\"20px\" open=\"off\"]<\/p> Fuentes-Baile M, P\u00e9rez-Valenciano E, <\/span>Garc\u00eda-Morales P<\/b>, <\/span>de Juan Romero C<\/b>, Bello-Gil D, Barber\u00e1 VM, Rodr\u00edguez-Lescure \u00c1, Sanz JM, Alenda C, <\/span>Saceda M<\/b>. CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients?<\/span><\/i> Int J Mol Sci<\/b>. 2021 Feb 2;22(3):1477. doi: 10.3390\/ijms22031477. PMID: 33540681; PMCID: PMC7867295.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> Fuentes-Baile M, Ventero MP, Encinar JA, <\/span>Garc\u00eda-Morales P<\/b>, Poveda-Deltell M, P\u00e9rez-Valenciano E, Barber\u00e1 VM, Gallego-Plazas J, Rodr\u00edguez-Lescure \u00c1, Mart\u00edn-Nieto J, <\/span>Saceda M.<\/b> Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines<\/span><\/i>. Cancers (Basel).<\/b> 2020 Dec 11;12(12):3717. doi: 10.3390\/cancers12123717. PMID: 33322337; PMCID: PMC7763458.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> Fuentes-Baile M, <\/span>Garc\u00eda-Morales P<\/b>, P\u00e9rez-Valenciano E, Ventero MP, Sanz JM, <\/span>de Juan Romero C<\/b>, Barber\u00e1 VM, Alenda C<\/span>, Saceda M<\/b>. <\/span>Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines<\/span><\/i>. <\/span>Int J Mol Sci<\/b>. 2020 Nov 12;21(22):8522. doi: 10.3390\/ijms21228522. PMID: 33198289; PMCID: PMC7697521.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> Fuentes-Baile M, Bello-Gil D, P\u00e9rez-Valenciano E, Sanz JM, <\/span>Garc\u00eda-Morales P<\/b>, Maestro B, Ventero MP, Alenda C, Barber\u00e1 VM, <\/span>Saceda M<\/b>. <\/span>CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells<\/span><\/i>. <\/span>Biomolecules<\/b>. 2020 Feb 3;10(2):222. doi: 10.3390\/biom10020222. PMID: 32028649; PMCID: PMC7072168.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> Ventero MP, Fuentes-Baile M, Quereda C, Perez-Valeciano E, Alenda C, <\/span>Garcia-Morales P<\/b>, Esposito D, Dorado P, Manuel Barbera V, <\/span>Saceda M<\/b>. <\/span>Radiotherapy resistance acquisition in Glioblastoma. Role of SOCS1 and SOCS3<\/span><\/i>. <\/span>PLoS One<\/b>. 2019 Feb 27;14(2):e0212581. doi: 10.1371\/journal.pone.0212581. Erratum in: PLoS One. 2019 Apr 16;14(4):e0215714. PMID: 30811476; PMCID: PMC6392282.<\/span><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"The centrosome protein AKNA regulates neurogenesis via microtubule organization\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"||||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> Camargo Ortega G*, Falk S*, Johansson PA*, Peyre E, Broix L, Sahu SK, Hirst W, Schlichthaerle T, <\/span>De Juan Romero C<\/b>, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Br\u00e4uninger M, Nguyen L, G\u00f6tz M. <\/span>The centrosome protein AKNA regulates neurogenesis via microtubule organization<\/span><\/i>. <\/span>Nature.<\/b> 2019 Mar;567(7746):113-117. doi: 10.1038\/s41586-019-0962-4. Epub 2019 Feb 20. PMID: 30787442. <\/span>(IF: 43.070 Q1).<\/b><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" custom_margin=\"-33px||-3px||false|false\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> C\u00e1rdenas A, Villalba A, <\/span>de Juan Romero C<\/b>, Pic\u00f3 E, Kyrousi C, Tzika AC, Tessier-Lavigne M, Ma L, Drukker M, Cappello S, Borrell V. <\/span>Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels.<\/span><\/i> Cell.<\/b> 2018 Jul 26;174(3):590-606.e21. doi: 10.1016\/j.cell.2018.06.007. Epub 2018 Jun 28. PMID: 29961574<\/span>. (IF: 31.398 Q1)<\/b><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"PDGFR and IGF-1R Inhibitors Induce a G2\/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines\" closed_toggle_text_color=\"#000000\" _builder_version=\"4.2.2\" body_text_color=\"#000000\" background_enable_color=\"off\" transform_translate=\"0px|-33px\" toggle_font=\"|600|||||||\" open=\"off\"]<\/p> Carrasco-Garcia E, Martinez-Lacaci I, Mayor-L\u00f3pez L, Tristante E, Carballo-Santana M, <\/span>Garc\u00eda-Morales P<\/b>, Ventero Martin MP, Fuentes-Baile M, Rodriguez-Lescure \u00c1, <\/span>Saceda M<\/b>. <\/span>PDGFR and IGF-1R Inhibitors Induce a G2\/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines.<\/span><\/i> Cells<\/b>. 2018 Sep 6;7(9):131. doi: 10.3390\/cells7090131. PMID: 30200644; PMCID: PMC6162497.<\/span><\/p> [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" background_enable_color=\"off\" custom_padding=\"80px||87px|||\" disabled=\"on\"][et_pb_row disabled_on=\"off|off|off\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" custom_margin=\"-60px|411px|-60px|auto|true|false\" custom_padding=\"1px||0px|||\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_accordion open_toggle_text_color=\"#ffffff\" open_toggle_background_color=\"#ffffff\" closed_toggle_text_color=\"#ffffff\" closed_toggle_background_color=\"#ab1a2d\" icon_color=\"#ffffff\" use_icon_font_size=\"on\" icon_font_size=\"32px\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" toggle_font=\"|700|||||||\" toggle_font_size=\"20px\" closed_toggle_font=\"||||||||\" body_text_color=\"#ffffff\" body_font_size=\"18px\" body_line_height=\"1.8em\" background_enable_color=\"off\" module_alignment=\"center\" height_tablet=\"\" height_phone=\"\" height_last_edited=\"on|desktop\" border_color_all=\"rgba(0,0,0,0)\" border_color_bottom=\"#ffffff\" disabled=\"on\"][et_pb_accordion_item open=\"on\" _builder_version=\"4.2.2\" custom_css_main_element=\"display:none;\"][\/et_pb_accordion_item][et_pb_accordion_item title=\" %22A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress.%22\" _builder_version=\"4.2.2\" background_color=\"rgba(0,0,0,0)\" background_enable_color=\"on\" background_enable_image=\"off\" link_option_url_new_window=\"on\" open=\"off\"]<\/p> Ruiz-Torres, V., N. 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(2021). \"The antimicrobial capacity of <\/span>Cistus salviifolius<\/span><\/i> and <\/span>Punica granatum <\/span><\/i>plant extracts against clinical pathogens is related to their polyphenolic composition.\" Scientific Reports 11(1): 588. <\/span>https:\/\/doi.org\/10.1038\/s41598-020-80003-y<\/span><\/a><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> \u00c1lvarez-Mart\u00ednez, F. J., E. Barraj\u00f3n-Catal\u00e1n, et al. (2021). \"Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.\" Phytomedicine 90: 153626. <\/span>https:\/\/doi.org\/10.1016\/j.phymed.2021.153626<\/span><\/a><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> E. Barraj\u00f3n-Catal\u00e1n; F.J. \u00c1lvarez-Mart\u00ednez; F. Borr\u00e1s; D.P\u00e9rez; N. Herrero; J.J. Ruiz; V. Micol. Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops. Food Chemistry. 310 - 125818, pp.1 - 9. <\/span>https:\/\/doi.org\/10.1016\/j.foodchem.2019.125818<\/span><\/a><\/p> [\/et_pb_accordion_item][et_pb_accordion_item title=\"%22Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.%22\" _builder_version=\"4.2.2\" background_color=\"#ab1a2d\" background_enable_color=\"on\" open=\"off\"]<\/p> Agull\u00f3-Chazarra, L., I. Borr\u00e1s-Linares, et al. (2020). \"Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Properties.\" Antioxidants 9(5): 418. <\/span>BIO-MULTIFUNCTIONAL ASSEMBLIES GROUP<\/span><\/strong><\/h2>\n
STRUCTURE-FUNCTION RELATIONSHIPS IN ION CHANNELS RESEARCH GROUP<\/span><\/strong><\/h2>\n
unidad de Biosensores<\/b><\/span> y Biorreconocimiento<\/strong><\/h1>
GRUPO DE INVESTIGACI\u00d3N MONTAJES BIO-MULTIFUNCIONALES<\/span><\/strong><\/h2>
GRUPO DE INVESTIGACI\u00d3N RELACIONES ESTRUCTURA-FUNCI\u00d3N EN CANALES I\u00d3NICOS<\/span><\/strong><\/h2>
Equipo en Quimiorresistencia y C\u00e1ncer<\/strong><\/span><\/h2>
Equipo en Neurobiolog\u00eda Molecular y C\u00e1ncer<\/strong><\/span><\/h2>
Investigadores principales<\/span><\/strong><\/span><\/h2>
Investigadores postdoctorales<\/span><\/strong><\/span><\/h2>
Estudiantes predoctorales<\/span><\/strong><\/span><\/h2>
T\u00e9cnicos\u00a0<\/strong><\/span><\/h2>
Publicaciones <\/span>representativas<\/span><\/strong><\/h2>