{"id":2406,"date":"2023-07-27T11:50:55","date_gmt":"2023-07-27T11:50:55","guid":{"rendered":"https:\/\/newidibe.zeus.umh.es\/?page_id=2406"},"modified":"2024-09-10T07:22:47","modified_gmt":"2024-09-10T07:22:47","slug":"clever","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/clever\/","title":{"rendered":"Clever"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; background_enable_color=&#8221;off&#8221; custom_padding=&#8221;||4px|||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row admin_label=&#8221;row&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_padding=&#8221;||19px|||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;Verdana|700|||||||&#8221; text_font_size=&#8221;30px&#8221; header_font=&#8221;|600|||||||&#8221; header_font_size=&#8221;50px&#8221; header_2_font=&#8221;|700||on|||||&#8221; header_2_text_color=&#8221;#003041&#8243; header_2_font_size=&#8221;54px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1><span style=\"color: #ab1a2d\">CLEVER<\/span><\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;1.6em&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: justify\"><strong>Development of biomolecules (CLEVER)<\/strong> is a platform that assembles the know-how and technology aimed at the identification and development of bioactive molecules from computational tracking (<em>in silico<\/em>) to their therapeutic, nutraceutical and\/or cosmeceutical validation. It uses natural and synthetic chemical libraries and brings together pre-clinical assays and models to characterize the function of active molecules. Additionally, it provides analytical technology to characterize their pharmacological properties. For natural chemical libraries, it includes a pilot plant for scaling up optimization of plant extracts.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;1.6em&#8221; text_orientation=&#8221;justified&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Platform coordinator:<span>\u00a0<\/span><\/strong><span>Enrique Barraj\u00f3n (<\/span><span id=\"eeb-118103-524446\">e.barrajon@umh.es<\/span><span>)<\/span><strong><\/strong><strong><\/strong><\/p>\n<p><strong>Equipment:<\/strong><br \/>Some of the equipment that is part of the CLEVER technological platform is listed below:<\/p>\n<ul>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/uhplc-ms-triple-cuadrupolo\/\">HPLC-MS chromatographic unit, Nexera, triple quadrupole LCMS-8050<\/a><\/li>\n<li>GC for Mass Spectrometer<\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/HPLC-DAD-UV-Vis-7000\/\"><span style=\"font-size: 20px\">UV\/Vis analytical HPLC-DAD 7000<\/span><\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/HPLC-DAD-ionisation-electrospray-ion-trap-mass-spectrometry\/%20\">HPLC-DAD mass spectrometry with electrospray ionization ion trap<\/a><\/li>\n<li>HPLC-GPC QP2010 Series Simadzu and RID-10A refractive index detector<\/li>\n<li>Preparative Buchi HPLC<\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/Spray-dryer-290\/%20\">Spray-dryer 290<\/a><\/li>\n<li>FPLC 900<\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/seamaty-biochemistry-analyzer\">Seamaty SMT-120 VT Biochemistry Analyzer<\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/respirometro-oroboros-o2k\/\">Breathalyser for cells, mitochondria or permeabilised tissue &#8211; Oroboros O2k<\/a><\/li>\n<li>Akta Start and FRAC30 Sweden ab chromatograph<\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/cytation-plate-readers\/\">Cytation 3 and Cytation One Plate Readers<\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/UP400St-ultrasonic-extraction-equipment\/%20\">UP400St ultrasonic extraction equipment<\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/Pilot-rotary-evaporator-R-220Pro\/%20\">Pilot rotavapor R-220Pro<\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/40Lreactor-thermostatised-temperature-controlled\/\">40 L reactor (thermostatted and temperature controlled)<\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/Centrifugation_Ultracentrifugation_Unit\/\">Centrifugation and Ultracentrifugation Unit<\/a><\/li>\n<li><a href=\"https:\/\/idibe.umh.es\/en\/servicios\/Biosafety-Laboratory-Level-2\/%20\"><span style=\"font-size: 20px\">Biosafety Laboratory Level 2<\/span><\/a><\/li>\n<\/ul>\n<p><strong>Biocomputing:<\/strong><\/p>\n<ul>\n<li>2 high-throughput clusters for molecular modeling and virtual screening.<\/li>\n<li>1 cluster of computers with a total of 4 Intel Xeon nodes and up to 40 processors.<\/li>\n<li>1 high-performance cluster for scientific computing provided with 8 nodes with Intel Xeon<\/li>\n<li>Platinum v5 8160-2.1GHz and Intel Xeon Gold 5120 processors, with 24 cores each, and Tesla V-100 or Nvidia CUDA graphics cards.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/idibe.umh.es\/files\/2023\/09\/clever.jpg&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_image src=&#8221;https:\/\/idibe.umh.es\/files\/2023\/09\/equipo-clever-scaled.jpg&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>CLEVERDevelopment of biomolecules (CLEVER) is a platform that assembles the know-how and technology aimed at the identification and development of bioactive molecules from computational tracking (in silico) to their therapeutic, nutraceutical and\/or cosmeceutical validation. It uses natural and synthetic chemical libraries and brings together pre-clinical assays and models to characterize the function of active molecules. [&hellip;]<\/p>\n","protected":false},"author":3158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.2.2\" background_enable_color=\"off\" custom_padding=\"||4px|||\" locked=\"off\"][et_pb_row admin_label=\"row\" _builder_version=\"4.2.2\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_padding=\"||19px|||\"][et_pb_column type=\"4_4\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.2.2\" text_font=\"Verdana|700|||||||\" text_font_size=\"30px\" header_font=\"|600|||||||\" header_font_size=\"50px\" header_2_font=\"|700||on|||||\" header_2_text_color=\"#003041\" header_2_font_size=\"54px\"]<\/p><h1><span style=\"color: #ab1a2d;\">Clever<\/span><\/h1><p>[\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" text_font_size=\"20px\" text_line_height=\"1.6em\" hover_enabled=\"0\"]<\/p><p style=\"text-align: justify;\"><strong>Desarrollo de biomol\u00e9culas (CLEVER)<\/strong> es una plataforma que aglutina el know-how y tecnolog\u00eda dirigida a la identificaci\u00f3n y desarrollo de mol\u00e9culas bioactivas desde el rastreo computacional (in silico) hasta su validaci\u00f3n terap\u00e9utica, nutrac\u00e9utica y\/o cosmec\u00e9utica. Usa quimiotecas naturales y sint\u00e9ticas, y re\u00fane los ensayos y modelos pre-cl\u00ednicos para caracterizar la funci\u00f3n de las biomol\u00e9culas, y la tecnolog\u00eda anal\u00edtica para caracterizar sus propiedades farmacol\u00f3gicas. Para quimiotecas naturales incluye una planta piloto para extractos vegetales.<\/p><p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2406"}],"collection":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/users\/3158"}],"replies":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/comments?post=2406"}],"version-history":[{"count":0,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2406\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media?parent=2406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}