{"id":2517,"date":"2023-07-28T08:24:00","date_gmt":"2023-07-28T08:24:00","guid":{"rendered":"https:\/\/newidibe.zeus.umh.es\/?page_id=2517"},"modified":"2024-02-26T08:48:59","modified_gmt":"2024-02-26T08:48:59","slug":"dra-ana-maria-fernandez-escamilla","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/dra-ana-maria-fernandez-escamilla\/","title":{"rendered":"Dra. Ana Mar\u00eda Fern\u00e1ndez-Escamilla"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#ffffff&#8221; custom_padding=&#8221;16px|0px|16px|0px|false|false&#8221; border_width_top=&#8221;3px&#8221; border_color_top=&#8221;#AB1A2D&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;11px|0px|0|0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/idibe.umh.es\/files\/2023\/03\/Ana-Maria-Fernandez-Escamilla.png&#8221; align=&#8221;center&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;150px||||false|false&#8221; custom_padding_tablet=&#8221;5px||||false|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_font_size=&#8221;55px&#8221; header_2_font=&#8221;Raleway||||||||&#8221; header_2_text_color=&#8221;#000000&#8243; header_2_font_size=&#8221;45px&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#ffffff&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: center\"><strong>Dr. Ana Mar\u00eda Fern\u00e1ndez-Escamilla<\/strong><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_2_font=&#8221;||||||||&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;|||on|||||&#8221; header_4_text_align=&#8221;center&#8221; header_4_text_color=&#8221;#ffffff&#8221; header_4_line_height=&#8221;1.4em&#8221; custom_margin=&#8221;-31px|107px||107px||false&#8221; custom_padding=&#8221;0px||&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><span style=\"color: #333333\">ASSOCIATE PROFESSOR OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, MIGUEL HERNANDEZ UNIVERSITY<\/span><\/h4>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#ffffff&#8221; background_enable_image=&#8221;off&#8221; parallax=&#8221;on&#8221; custom_padding=&#8221;36px|0px|35px|0px|false|false&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,2_3&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb use_icon=&#8221;on&#8221; font_icon=&#8221;&#x5d;||divi||400&#8243; icon_color=&#8221;#c0172d&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_line_height=&#8221;1.1em&#8221; custom_padding=&#8221;20px|20px|1px|20px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Unit<\/strong><br \/> Antiviral Strategies<\/p>\n<p>[\/et_pb_blurb][et_pb_blurb use_icon=&#8221;on&#8221; font_icon=&#8221;&#x5e;||divi||400&#8243; icon_color=&#8221;#c0172d&#8221; icon_placement=&#8221;left&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||&#8221; custom_padding=&#8221;0px|20px|1px|20px|false|true&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<strong>Subunit<\/strong><br \/>\nEnvironmental Signaling and Disease<br \/>\n[\/et_pb_blurb][et_pb_blurb use_icon=&#8221;on&#8221; font_icon=&#8221;&#xe08b;||divi||400&#8243; icon_color=&#8221;#c0172d&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||&#8221; custom_padding=&#8221;0px|20px|1px|20px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Group<\/strong><br \/> Protein Arquitecture Lab<\/p>\n<p>[\/et_pb_blurb][et_pb_blurb use_icon=&#8221;on&#8221; font_icon=&#8221;&#xe076;||divi||400&#8243; icon_color=&#8221;#c0172d&#8221; icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_text_color=&#8221;#000000&#8243; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||&#8221; custom_padding=&#8221;0px|20px|1px|20px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<span style=\"color: #333333\"><a style=\"color: #333333\" href=\"mailto:ana.fernandeze@umh.es\"><span style=\"font-weight: 400\">ana.fernandeze@umh.es<\/span><\/a><\/span>[\/et_pb_blurb][et_pb_blurb icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||&#8221; custom_padding=&#8221;0px|20px|1px|3px|false|false&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/www.linkedin.com\/in\/ana-maria-fernandez-escamilla\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" class=\"wp-image-796 alignnone size-thumbnail\" src=\"http:\/\/idibe.umh.es\/files\/2023\/03\/linkedinlogo-150x150.png\" alt=\"\" width=\"23\" height=\"68\" \/><\/a>[\/et_pb_blurb][et_pb_blurb icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||&#8221; custom_padding=&#8221;0px|20px|1px|3px|false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/orcid.org\/0000-0002-6615-4913\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"wp-image-3808 alignnone size-large\" src=\"http:\/\/idibe.umh.es\/files\/2022\/09\/ORCID_logo.svg_-1024x348-1.png\" alt=\"\" width=\"68\" height=\"23\" \/><\/a>[\/et_pb_blurb][et_pb_blurb icon_placement=&#8221;left&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||&#8221; custom_padding=&#8221;0px|20px|20px|3px|false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/scholar.google.es\/citations?user=DsJdw3YAAAAJ&amp;amp;hl=es&amp;amp;oi=ao\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"wp-image-775 alignnone size-medium\" src=\"http:\/\/idibe.umh.es\/files\/2023\/02\/Google_Scholar_logo-300x50.png\" alt=\"\" width=\"114\" height=\"19\" srcset=\"https:\/\/idibe.umh.es\/files\/2023\/02\/Google_Scholar_logo-300x50.png 300w, https:\/\/idibe.umh.es\/files\/2023\/02\/Google_Scholar_logo-480x81.png 480w, https:\/\/idibe.umh.es\/files\/2023\/02\/Google_Scholar_logo.png 762w\" sizes=\"(max-width: 114px) 100vw, 114px\" \/><\/a>[\/et_pb_blurb][et_pb_blurb use_icon=&#8221;on&#8221; font_icon=&#8221;&#xe090;||divi||400&#8243; icon_color=&#8221;#c0172d&#8221; icon_placement=&#8221;left&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_margin=&#8221;-14px||||false|false&#8221; custom_padding=&#8221;0px|20px|20px|20px|false|true&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]+34 96 522 2002<br \/>\n[\/et_pb_blurb][et_pb_text disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;26px&#8221; header_4_line_height=&#8221;1.4em&#8221; background_color=&#8221;#ffffff&#8221; text_orientation=&#8221;center&#8221; custom_margin=&#8221;-25px||||false|false&#8221; custom_padding=&#8221;0px|0px|40px|0px|false|true&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p style=\"text-align: left;padding-left: 30px\"><a href=\"https:\/\/orcid.org\/0000-0003-1065-5388\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"wp-image-3808 alignnone size-large\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/09\/ORCID_logo.svg_-1024x348-1.png\" alt=\"\" width=\"68\" height=\"23\" \/><\/a><\/p>\n<p style=\"padding-left: 30px\"><a href=\"https:\/\/scholar.google.es\/citations?user=othzU4sAAAAJ&amp;hl=es\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"wp-image-775 alignnone size-medium\" style=\"float: left\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/02\/Google_Scholar_logo-300x50.png\" alt=\"\" width=\"114\" height=\"19\" \/><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.17.4&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;25px&#8221; header_4_line_height=&#8221;1.4em&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>RESEARCH FIELDS<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.17.4&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;15px&#8221; header_font=&#8221;||||||||&#8221; header_2_font=&#8221;||||||||&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_5_font=&#8221;||||||||&#8221; header_6_font=&#8221;||||||||&#8221; custom_margin=&#8221;-31px||0px&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>Use of bioinformatics and experimental methods in:<\/p>\n<ul>\n<li>Identification of small molecules and peptides with pharmacological potential.<span style=\"font-size: 15px\"><\/span><\/li>\n<li>\n<p>Identification and biochemical, biophysical and structural characterization of macromolecules as therapeutic targets.<\/p>\n<\/li>\n<li>\n<p>Molecular characterization of protein-ligand interactions with pharmacological potential.<\/p>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_toggle title=&#8221;PROFESSIONAL BACKGROUND&#8221; icon_color=&#8221;#c0172d&#8221; open_icon_color=&#8221;#c0172d&#8221; _builder_version=&#8221;4.16&#8243; title_text_color=&#8221;#c0172d&#8221; title_level=&#8221;h4&#8243; title_font=&#8221;||||||||&#8221; body_font=&#8221;||||||||&#8221; body_text_color=&#8221;#000000&#8243; background_color=&#8221;#ffffff&#8221; custom_padding=&#8221;32px|32px|32px|32px|true|true&#8221; border_radii=&#8221;on|3px|3px|3px|3px&#8221; border_width_all=&#8221;0px&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;rgba(153,153,153,0.14)&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li><strong>Previous positions:<\/strong><br \/>1. Senior Researcher. National Programme for the Promotion of Talent and Its Employability, Ram\u00f3n y Cajal National Sub-Programme. Environmental Protection Department. Estaci\u00f3n Experimental del Zaid\u00edn (EEZ), Spanish National Research Council (CSIC). 2010-2016.<br \/>2. Research Associate. Environmental Protection Department. EEZ (CSIC). 2009-2010.<br \/>3. Research Associate. Biochemistry and Molecular Parasitology Group. Institute of Biotechnology. University of Granada (UGR). Mar 2009.<br \/>4. Research Associate. Microbial Antagonists Substances Group. Microbiology Department. Faculty of Sciences. UGR. 2007-2008.<br \/>5. Postdoctoral Research Fellow. Medicinal Chemistry Unit. Structural Biology Laboratory. Felipe Prince Research Centre (CIPF). 2005-2006.<br \/>6. Postdoctoral Research Fellow. Structure and Molecular Spectroscopy Unit. Physical Chemistry Rocasolano Institute. Spanish National Research Council (CSIC). 2003.<br \/>7. Postdoctoral Research Fellow &#8211; Marie Sk\u0142odowska-Curie. Structural and Computational Biology Unit. European Molecular Biology Laboratory (EMBL). Heidelberg (Germany). 2001-2005.<br \/>8. European Molecular Biology Organization (EMBO) predoctoral-fellow. Agricultural University of Norway. Molecular Genetic Laboratory (LMG). Department of Biotechnologies Sciences. 1998.<br \/>9. European Community Fellow. Department of Physical Chemistry. Faculty of Sciences. University of Granada (UGR). 1997-2000.<strong style=\"font-size: 14px\"><\/strong><\/li>\n<li><strong>PhD programme:<\/strong>\u00a0Methodology and Treatment of the Chemical Phenomena.<\/li>\n<li><strong>Degree<\/strong> in Chemical Sciences.<\/li>\n<\/ul>\n<p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,2_3&#8243; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;26px&#8221; header_4_line_height=&#8221;1.4em&#8221; background_color=&#8221;#ffffff&#8221; text_orientation=&#8221;center&#8221; custom_padding=&#8221;10px|0px|0px|0px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"https:\/\/orcid.org\/0000-0003-4178-2152\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"wp-image-3808 alignnone size-large\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/09\/ORCID_logo.svg_-1024x348-1.png\" alt=\"\" width=\"106\" height=\"36\" \/><\/a><\/p>\n<p><a href=\"https:\/\/scholar.google.es\/citations?user=othzU4sAAAAJ&amp;hl=es\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" class=\"wp-image-760 alignnone size-full\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/02\/logo_google_scholar.png\" alt=\"\" width=\"106\" height=\"188\" \/><\/a><br \/>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;30.375px|0px|0|0px|false|false&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;26px&#8221; header_4_line_height=&#8221;1.4em&#8221; custom_margin=&#8221;||8px&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>REPRESENTATIVE PUBLICATIONS<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; make_equal=&#8221;on&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;15px|0px|15px|0px|true|false&#8221; custom_width_px=&#8221;1669px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;hover_blurb&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;FERNANDEZ-ESCAMILLA AM.*, S\u00c1NCHEZ-HIDALGO M.*, ET AL. (2010)&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_padding=&#8221;25px|25px|25px|25px|true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]Protein and Peptide Letters, DOI:\u00a0<a class=\"doi\" href=\"https:\/\/doi.org\/10.2174\/092986610791190390\" target=\"_blank\" rel=\"noopener noreferrer\">10.2174\/092986610791190390<\/a><\/p>\n<p><em>Conformational stability and activity of circular enterocin AS-48 derivatives.<\/em><br \/>\n[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;hover_blurb&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;FERNANDEZ-ESCAMILLA A.M., ET AL. (2006)&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_padding=&#8221;25px|25px|25px|25px|true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]Protein Science, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1110\/ps.062186506\" target=\"_blank\" rel=\"noopener noreferrer\">10.1110\/ps.062186506<\/a><\/p>\n<p><em>Design and NMR conformational study of a beta-sheet peptide based on Betanova and WW domains.<\/em><br \/>\n[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; make_equal=&#8221;on&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;15px|0px|15px|0px|true|false&#8221; custom_width_px=&#8221;1669px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;hover_blurb&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;FERNANDEZ-ESCAMILLA A. M., ET AL. (2004)&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.3em&#8221; custom_padding=&#8221;25px|25px|25px|25px|true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]Nature Biotechnology, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1038\/nbt1012\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/nbt1012<\/a><\/p>\n<p><em>Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins.<\/em><br \/>\n[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;hover_blurb&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;FERNANDEZ-ESCAMILLA A. M., ET AL. (2004)&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.1em&#8221; custom_padding=&#8221;25px|25px|25px|25px|true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]Proceedings of the National Academy of Science of the United States of America: PNAS, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1073\/pnas.0304180101\" target=\"_blank\" rel=\"noopener noreferrer\">10.1073\/pnas.0304180101<\/a><\/p>\n<p><em>Solvation in protein folding analysis, combination of theoretical and experimental approaches..<\/em><br \/>\n[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; make_equal=&#8221;on&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;15px|0px|15px|0px|true|false&#8221; custom_width_px=&#8221;1669px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;hover_blurb&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb title=&#8221;FERNANDEZ A. M., ET AL. (2000)&#8221; _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.3em&#8221; custom_padding=&#8221;25px|25px|25px|25px|true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]European Journal of Biochemistry, DOI:\u00a0<a class=\"epub-doi\" href=\"https:\/\/doi.org\/10.1046\/j.1432-1327.2000.01638.x\" aria-label=\"Digital Object Identifier\">10.1046\/j.1432-1327.2000.01638.x<\/a><\/p>\n<p><em>Thermodynamic analysis of helix-engineered forms of the activation domain of human procarboxypeptidase A2.<\/em><br \/>\n[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; module_class=&#8221;hover_blurb&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_line_height=&#8221;1.3em&#8221; custom_padding=&#8221;25px|25px|25px|25px|true&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;30.375px|0px|0|0px|false|false&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;26px&#8221; header_4_line_height=&#8221;1.4em&#8221; custom_margin=&#8221;||8px&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>PATENTS AND AVAILABLE TECHNOLOGIES<\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; make_equal=&#8221;on&#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;15px|0px|15px|0px|true|false&#8221; custom_width_px=&#8221;1669px&#8221; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;rgba(255,255,255,0.5)&#8221; custom_padding=&#8221;|||&#8221; custom_css_main_element=&#8221;box-shadow: 0 20px 80px rgba(50,50,93,.09);&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_blurb _builder_version=&#8221;4.16&#8243; header_font=&#8221;Josefin Sans|||on|||||&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#c0172d&#8221; header_line_height=&#8221;1.2em&#8221; body_font=&#8221;||||||||&#8221; body_text_color=&#8221;#000000&#8243; custom_padding=&#8221;25px||25px||true|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li><a href=\"http:\/\/tango.crg.es\/\">TANGO<\/a>.\u00a0<em>A computer algorithm designed to predict aggregation nucleating regions in proteins, as well as the effect of mutations and environmental conditions on the aggregation propensity of these regions.<\/em>\u00a0We derived a statistical mechanics algorithm, TANGO, based on simple physico-chemical principles of secondary structure formation extended by the assumption that the core regions of an aggregate are fully buried. TANGO was benchmarked against 175 peptides of over 20 proteins and was able to predict the sequences experimentally observed to contribute to the aggregation of these proteins. Further TANGO correctly predicts the aggregation propensities of several disease-related mutations in the Alzheimer\u2019s b-peptide. Our algorithm, therefore, opens the possibility to screen large databases for potentially disease-related aggregation motifs as well as to optimize recombinant protein yields by rationally out-designing protein aggregation.<\/li>\n<\/ul>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.16&#8243; disabled=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;26px&#8221; header_4_line_height=&#8221;1.4em&#8221; custom_margin=&#8221;||8px&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4>COMPANY AGREEMENTS<\/h4>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;||||||||&#8221; header_text_color=&#8221;#c0172d&#8221; header_3_font=&#8221;||||||||&#8221; header_4_font=&#8221;||||||||&#8221; header_4_text_color=&#8221;#c0172d&#8221; header_4_font_size=&#8221;26px&#8221; header_4_line_height=&#8221;1.4em&#8221; custom_margin=&#8221;||8px&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|true&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<ul>\n<li>Detection of toxic compounds by the bacterial biosensor based on the TtgR repressor of Pseudomonas putida DOT -T1E. Financial Entities: GRONTAL Biotechnological Solutions S.L. and Spanish National Research Council (CSIC). Principal Investigator: Ana Mar\u00eda Fern\u00e1ndez Escamilla.<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Ana Mar\u00eda Fern\u00e1ndez-EscamillaASSOCIATE PROFESSOR OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, MIGUEL HERNANDEZ UNIVERSITY &nbsp;Unit Antiviral StrategiesSubunit Environmental Signaling and Disease Group Protein Arquitecture Labana.fernandeze@umh.es+34 96 522 2002 RESEARCH FIELDSUse of bioinformatics and experimental methods in: Identification of small molecules and peptides with pharmacological potential. Identification and biochemical, biophysical and structural characterization of macromolecules as therapeutic [&hellip;]<\/p>\n","protected":false},"author":3782,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>[et_pb_section fb_built=\"1\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" custom_padding=\"16px|0px|16px|0px|false|false\" border_width_top=\"3px\" border_color_top=\"#AB1A2D\"][et_pb_row column_structure=\"1_3,2_3\" _builder_version=\"4.2.2\" custom_padding=\"11px|0px|0|0px|false|false\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/Ana-Maria-Fernandez-Escamilla.png\" align=\"center\" _builder_version=\"4.2.2\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"2_3\" _builder_version=\"4.2.2\" custom_padding=\"150px||||false|false\" custom_padding_tablet=\"5px||||false|false\" custom_padding_phone=\"\" custom_padding_last_edited=\"on|phone\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.2.2\" header_font=\"||||||||\" header_font_size=\"55px\" header_2_font=\"Raleway||||||||\" header_2_text_color=\"#000000\" header_2_font_size=\"45px\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#ffffff\"]<\/p><h2 style=\"text-align: center;\"><strong><span style=\"color: #333333;\">Dra. <\/span>Ana Mar\u00eda<span style=\"color: #333333;\">\u00a0Fern\u00e1ndez-Escamilla<\/span><\/strong><\/h2><p>[\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_2_font=\"||||||||\" header_3_font=\"||||||||\" header_4_font=\"|||on|||||\" header_4_text_align=\"center\" header_4_text_color=\"#ffffff\" header_4_line_height=\"1.4em\" custom_margin=\"-31px|107px||107px||false\" custom_padding=\"0px||\"]<\/p><h4><span style=\"color: #333333;\">ASSOCIATE PROFESSOR, UNIVERSIDAD MIGUEL HERNANDEZ<\/span><\/h4><p>\u00a0<\/p><p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"section\" _builder_version=\"4.2.2\" background_color=\"#ffffff\" background_enable_image=\"off\" parallax=\"on\" custom_padding=\"36px|0px|35px|0px|false|false\"][et_pb_row column_structure=\"1_3,2_3\" _builder_version=\"4.16\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb use_icon=\"on\" font_icon=\"%%60%%\" icon_color=\"#c0172d\" icon_placement=\"left\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"20px|20px|1px|20px|false|true\" hover_enabled=\"0\"]<\/p><p><strong>Unit<\/strong><br \/>Antiviral Strategies<\/p><p>[\/et_pb_blurb][et_pb_blurb use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#c0172d\" icon_placement=\"left\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||\" custom_padding=\"0px|20px|1px|20px|false|true\" disabled=\"on\"]<\/p><p><strong>Subunit<\/strong><br \/>Environmental Signaling and Disease<\/p><p>[\/et_pb_blurb][et_pb_blurb use_icon=\"on\" font_icon=\"%%259%%\" icon_color=\"#c0172d\" icon_placement=\"left\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||\" custom_padding=\"0px|20px|1px|20px|false|true\" hover_enabled=\"0\"]<\/p><p><strong>Group<\/strong><br \/>Protein Arquitecture Lab<\/p><p>[\/et_pb_blurb][et_pb_blurb use_icon=\"on\" font_icon=\"%%238%%\" icon_color=\"#c0172d\" icon_placement=\"left\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||\" custom_padding=\"0px|20px|1px|20px|false|true\"]<span style=\"color: #333333;\"><a style=\"color: #333333;\" href=\"mailto:ana.fernandeze@umh.es\"><span style=\"font-weight: 400;\">ana.fernandeze@umh.es<\/span><\/a><\/span>[\/et_pb_blurb][et_pb_blurb icon_placement=\"left\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||\" custom_padding=\"0px|20px|1px|3px|false|false\" locked=\"off\"]<a href=\"https:\/\/www.linkedin.com\/in\/ana-maria-fernandez-escamilla\" target=\"_blank\" rel=\"noopener\"><img class=\"wp-image-796 alignnone size-thumbnail\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/03\/linkedinlogo-150x150.png\" alt=\"\" width=\"23\" height=\"68\" \/><\/a>[\/et_pb_blurb][et_pb_blurb icon_placement=\"left\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||\" custom_padding=\"0px|20px|1px|3px|false|false\"]<\/p><p><a href=\"https:\/\/orcid.org\/0000-0002-6615-4913\" target=\"_blank\" rel=\"noopener noreferrer\"><img class=\"wp-image-3808 alignnone size-large\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/09\/ORCID_logo.svg_-1024x348-1.png\" alt=\"\" width=\"68\" height=\"23\" \/><\/a><\/p><p>[\/et_pb_blurb][et_pb_blurb icon_placement=\"left\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||\" custom_padding=\"0px|20px|20px|3px|false|false\"]<\/p><p><a href=\"https:\/\/scholar.google.es\/citations?user=DsJdw3YAAAAJ&amp;hl=es&amp;oi=ao\" target=\"_blank\" rel=\"noopener noreferrer\"><img class=\"wp-image-775 alignnone size-medium\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/02\/Google_Scholar_logo-300x50.png\" alt=\"\" width=\"114\" height=\"19\" \/><\/a><\/p><p>[\/et_pb_blurb][et_pb_blurb use_icon=\"on\" font_icon=\"%%264%%\" icon_color=\"#c0172d\" icon_placement=\"left\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_margin=\"-14px||||false|false\" custom_padding=\"0px|20px|20px|20px|false|true\" disabled=\"on\"]<\/p><p>+34 96 522 2002<\/p><p>[\/et_pb_blurb][et_pb_text disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" background_color=\"#ffffff\" text_orientation=\"center\" custom_margin=\"-25px||||false|false\" custom_padding=\"0px|0px|40px|0px|false|true\" disabled=\"on\"]<\/p><p style=\"text-align: left; padding-left: 30px;\"><a href=\"https:\/\/orcid.org\/0000-0003-1065-5388\" target=\"_blank\" rel=\"noopener noreferrer\"><img class=\"wp-image-3808 alignnone size-large\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/09\/ORCID_logo.svg_-1024x348-1.png\" alt=\"\" width=\"68\" height=\"23\" \/><\/a><\/p><p style=\"padding-left: 30px;\"><a href=\"https:\/\/scholar.google.es\/citations?user=othzU4sAAAAJ&hl=es\" target=\"_blank\" rel=\"noopener noreferrer\"><img class=\"wp-image-775 alignnone size-medium\" style=\"float: left;\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/02\/Google_Scholar_logo-300x50.png\" alt=\"\" width=\"114\" height=\"19\" \/><\/a><\/p><p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"2_3\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.2.2\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"25px\" header_4_line_height=\"1.4em\"]<\/p><h4>RESEARCH FIELDS<\/h4><p>[\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" text_font=\"||||||||\" text_text_color=\"#000000\" text_font_size=\"15px\" header_font=\"||||||||\" header_2_font=\"||||||||\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_5_font=\"||||||||\" header_6_font=\"||||||||\" custom_margin=\"-31px||0px\"]<\/p><ul><li>Protein engineering.<\/li><li>Protein-ligand binding interactions and protein-protein interaction.<\/li><li>Molecular modeling.<\/li><li>Biochemical, biophysical and structural characterization of proteins.<\/li><li>New amyloids: exploitation in biomedicine, food security (food allergy) and sustainable agriculture.<\/li><li>Bacterial biosensor development for detection of toxic and antimicrobial compounds.<\/li><li>Characterization of the molecular mechanisms involved in microorganism-environment interaction.<\/li><\/ul><p>[\/et_pb_text][et_pb_toggle title=\"PROFESSIONAL BACKGROUND\" icon_color=\"#c0172d\" _builder_version=\"4.2.2\" title_text_color=\"#c0172d\" title_level=\"h4\" title_font=\"||||||||\" body_font=\"||||||||\" background_color=\"#ffffff\" custom_padding=\"32px|32px|32px|32px|true|true\" border_radii=\"on|3px|3px|3px|3px\" border_width_all=\"0px\" box_shadow_style=\"preset1\" box_shadow_color=\"rgba(153,153,153,0.14)\"]<\/p><ul><li><strong>Previous positions:<\/strong><br \/>1. Senior Researcher. National Programme for the Promotion of Talent and Its Employability, Ram\u00f3n y Cajal National Sub-Programme. Environmental Protection Department. Estaci\u00f3n Experimental del Zaid\u00edn (EEZ), Spanish National Research Council (CSIC). 2010-2016.<br \/>2. Research Associate. Environmental Protection Department. EEZ (CSIC). 2009-2010.<br \/>3. Research Associate. Biochemistry and Molecular Parasitology Group. Institute of Biotechnology. University of Granada (UGR). Mar 2009.<br \/>4. Research Associate. Microbial Antagonists Substances Group. Microbiology Department. Faculty of Sciences. UGR. 2007-2008.<br \/>5. Postdoctoral Research Fellow. Medicinal Chemistry Unit. Structural Biology Laboratory. Felipe Prince Research Centre (CIPF). 2005-2006.<br \/>6. Postdoctoral Research Fellow. Structure and Molecular Spectroscopy Unit. Physical Chemistry Rocasolano Institute. Spanish National Research Council (CSIC). 2003.<br \/>7. Postdoctoral Research Fellow. Structural and Computational Biology Unit. European Molecular Biology Laboratory (EMBL). Heidelberg (Germany). 2001-2005.<br \/>8. European Molecular Biology Organization (EMBO) predoctoral-fellow. Agricultural University of Norway. Molecular Genetic Laboratory (LMG), Department of Biotechnologies Sciences. 1998.<br \/>9. European Community Fellow. Department of Physical Chemistry. Faculty of Sciences. University of Granada (UGR). 1997-2000.<\/li><li><strong>Postdoctoral positions:<\/strong><\/li><li><strong>PhD programme:<\/strong>\u00a0Methodology and Treatment of the Chemical Phenomena.<\/li><li><strong>Degree<\/strong>\u00a0in Chemical Sciences.<\/li><li>\u00a0<\/li><\/ul><p>[\/et_pb_toggle][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_3,2_3\" disabled_on=\"on|on|on\" _builder_version=\"4.16\" disabled=\"on\"][et_pb_column type=\"1_3\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.2.2\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" background_color=\"#ffffff\" text_orientation=\"center\" custom_padding=\"10px|0px|0px|0px|false|true\"]<\/p><p><a href=\"https:\/\/orcid.org\/0000-0003-4178-2152\" target=\"_blank\" rel=\"noopener noreferrer\"><img class=\"wp-image-3808 alignnone size-large\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2022\/09\/ORCID_logo.svg_-1024x348-1.png\" alt=\"\" width=\"106\" height=\"36\" \/><\/a><\/p><p><a href=\"https:\/\/scholar.google.es\/citations?user=othzU4sAAAAJ&hl=es\" target=\"_blank\" rel=\"noopener noreferrer\"><img class=\"wp-image-760 alignnone size-full\" src=\"http:\/\/newidibe.zeus.umh.es\/files\/2023\/02\/logo_google_scholar.png\" alt=\"\" width=\"106\" height=\"188\" \/><\/a><\/p><p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"2_3\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=\"on|on|on\" _builder_version=\"4.16\" custom_padding=\"30.375px|0px|0|0px|false|false\" disabled=\"on\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p><h4>REPRESENTATIVE PUBLICATIONS<\/h4><p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" disabled_on=\"on|on|on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\" disabled=\"on\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"FERNANDEZ-ESCAMILLA AM.*, S\u00c1NCHEZ-HIDALGO M.*, ET AL. (2010)\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p><p>Protein and Peptide Letters, DOI:\u00a0<a class=\"doi\" href=\"https:\/\/doi.org\/10.2174\/092986610791190390\" target=\"_blank\" rel=\"noopener noreferrer\">10.2174\/092986610791190390<\/a><\/p><p><em>Conformational stability and activity of circular enterocin AS-48 derivatives.<\/em><\/p><p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"FERNANDEZ-ESCAMILLA A.M., ET AL. (2006)\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p><p>Protein Science, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1110\/ps.062186506\" target=\"_blank\" rel=\"noopener noreferrer\">10.1110\/ps.062186506<\/a><\/p><p><em>Design and NMR conformational study of a beta-sheet peptide based on Betanova and WW domains.<\/em><\/p><p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" disabled_on=\"on|on|on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\" disabled=\"on\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"FERNANDEZ-ESCAMILLA A. M., ET AL. (2004)\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.3em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p><p>Nature Biotechnology, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1038\/nbt1012\" target=\"_blank\" rel=\"noopener noreferrer\">10.1038\/nbt1012<\/a><\/p><p><em>Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins.<\/em><\/p><p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"FERNANDEZ-ESCAMILLA A. M., ET AL. (2004)\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p><p>Proceedings of the National Academy of Science of the United States of America: PNAS, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1073\/pnas.0304180101\" target=\"_blank\" rel=\"noopener noreferrer\">10.1073\/pnas.0304180101<\/a><\/p><p><em>Solvation in protein folding analysis, combination of theoretical and experimental approaches..<\/em><\/p><p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" disabled_on=\"on|on|on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\" disabled=\"on\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"FERNANDEZ A. M., ET AL. (2000)\" _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.3em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p><p>European Journal of Biochemistry, DOI:\u00a0<a class=\"epub-doi\" href=\"https:\/\/doi.org\/10.1046\/j.1432-1327.2000.01638.x\" aria-label=\"Digital Object Identifier\">10.1046\/j.1432-1327.2000.01638.x<\/a><\/p><p><em>Thermodynamic analysis of helix-engineered forms of the activation domain of human procarboxypeptidase A2.<\/em><\/p><p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.3em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=\"on|on|on\" _builder_version=\"4.16\" custom_padding=\"30.375px|0px|0|0px|false|false\" disabled=\"on\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p><h4>PATENTS AND AVAILABLE TECHNOLOGIES<\/h4><p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"3_5,2_5\" make_equal=\"on\" disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\" disabled=\"on\"][et_pb_column type=\"3_5\" _builder_version=\"4.2.2\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb _builder_version=\"4.2.2\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_text_color=\"#000000\" custom_padding=\"25px||25px||true|false\"]<\/p><ul><li><a href=\"http:\/\/tango.crg.es\/\">TANGO<\/a>.\u00a0<em>A computer algorithm designed to predict aggregation nucleating regions in proteins, as well as the effect of mutations and environmental conditions on the aggregation propensity of these regions.<\/em>\u00a0We derived a statistical mechanics algorithm, TANGO, based on simple physico-chemical principles of secondary structure formation extended by the assumption that the core regions of an aggregate are fully buried. TANGO was benchmarked against 175 peptides of over 20 proteins and was able to predict the sequences experimentally observed to contribute to the aggregation of these proteins. Further TANGO correctly predicts the aggregation propensities of several disease-related mutations in the Alzheimer\u2019s b-peptide. Our algorithm, therefore, opens the possibility to screen large databases for potentially disease-related aggregation motifs as well as to optimize recombinant protein yields by rationally out-designing protein aggregation.<\/li><\/ul><p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"2_5\" _builder_version=\"4.2.2\"][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=\"on|on|on\" _builder_version=\"4.2.2\" disabled=\"on\"][et_pb_column type=\"4_4\" _builder_version=\"4.2.2\"][et_pb_text _builder_version=\"4.2.2\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p><h4>COMPANY AGREEMENTS<\/h4><p>[\/et_pb_text][et_pb_text _builder_version=\"4.2.2\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p><ul><li>Detection of toxic compounds by the bacterial biosensor based on the TtgR repressor of Pseudomonas putida DOT -T1E. Financial Entities: GRONTAL Biotechnological Solutions S.L. and Spanish National Research Council (CSIC). Principal Investigator: Ana Mar\u00eda Fern\u00e1ndez Escamilla.<\/li><\/ul><p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2517"}],"collection":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/users\/3782"}],"replies":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/comments?post=2517"}],"version-history":[{"count":0,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/2517\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media?parent=2517"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}