{"id":3873,"date":"2023-09-27T22:07:14","date_gmt":"2023-09-27T22:07:14","guid":{"rendered":"https:\/\/idibe.umh.es\/?page_id=3873"},"modified":"2023-09-27T22:07:22","modified_gmt":"2023-09-27T22:07:22","slug":"red-blood-cells-in-antiviral-immunology","status":"publish","type":"page","link":"https:\/\/idibe.umh.es\/en\/red-blood-cells-in-antiviral-immunology\/","title":{"rendered":"Red Blood Cells in Antiviral Immunology"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.16″ background_image=”https:\/\/idibe.umh.es\/files\/2022\/09\/colors_light.png” parallax=”on” custom_padding=”54px|0px|18px|0px|false|false” locked=”off”][et_pb_row _builder_version=”4.16″ custom_padding=”28px|0px|29px|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”||||||||” header_font_size=”55px”]<\/p>\n

RESEARCH<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”#c0172d” custom_padding=”16px|0px|16px|0px|false|false” locked=”off”][et_pb_row _builder_version=”4.16″ custom_padding=”11px|0px|0|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”||||||||” header_font_size=”55px” header_2_font=”Raleway||||||||” header_2_text_color=”#ffffff” header_2_font_size=”45px” header_3_font=”||||||||” header_4_font=”||||||||” header_4_text_color=”#ffffff”]<\/p>\n

Red Blood Cells in Antiviral Immunology<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”section” _builder_version=”4.16″ background_image=”https:\/\/idibe.umh.es\/files\/2022\/09\/fondo-team.png” parallax=”on” custom_padding=”36px|0px|35px|0px|false|false” locked=”off”][et_pb_row column_structure=”1_3,2_3″ _builder_version=”4.16″ custom_padding=”30.375px|0px|23px|0px|false|false”][et_pb_column type=”1_3″ _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/idibe.umh.es\/files\/2023\/09\/Grupo-Red-Blood-Cells-IDiBE.jpg” _builder_version=”4.16″][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”||||||||” header_text_color=”#c0172d” header_4_font=”||||||||” header_4_text_color=”#c0172d” header_4_font_size=”25px” header_4_line_height=”1.4em” custom_padding=”20px|0px|0px|0px|false|true”]<\/p>\n

RESEARCH HIGHLIGHTS<\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_text_color=”#2bd1d1″ text_font_size=”15px” header_font=”||||||||” header_2_font=”||||||||” header_3_font=”||||||||” header_4_font=”||||||||” header_5_font=”||||||||” header_6_font=”||||||||” custom_margin=”-31px||0px” locked=”off”]The results obtained from our group have demonstrated that rainbow trout RBCs can respond to viral infections by themselves with an innate immune response, by means of producing antiviral molecules and exerting a paracrine antiviral communication with other cells, and with a potential adaptive immune response, by means of antigen processing and presentation and complement system regulation.Fish immunology and virology.<\/span><\/p>\n

 
\n[\/et_pb_text][et_pb_toggle title=”SCIENTIFIC INTERESTS” icon_color=”#c0172d” _builder_version=”4.16″ title_text_color=”#c0172d” title_level=”h4″ title_font=”||||||||” body_font=”||||||||” background_color=”#ffffff” custom_padding=”32px|32px|32px|32px|true|true” border_radii=”on|3px|3px|3px|3px” border_width_all=”0px” box_shadow_style=”preset1″ box_shadow_color=”rgba(153,153,153,0.14)”]<\/p>\n

Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle.<\/span><\/p>\n


\nIn 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production.
\nFurthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity.
\nIn the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our work on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that we chose a working model composed of the rainbow trout, the viral haemorrhagic septicaemia virus (VHSV) and the glycoprotein G of VHSV (GVHSV), the antigen encoded by this DNA vaccine.<\/span><\/p>\n

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NEWS<\/h4>\n

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MEMBERS<\/h4>\n

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Senior Research<\/p>\n

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Postdoctoral Researcher<\/p>\n

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PhD Student<\/p>\n

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PhD Student<\/p>\n

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FORMER MEMBERS<\/h4>\n

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Graduated PhD Student<\/p>\n

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Graduated PhD Student<\/p>\n

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Support Personnel<\/p>\n

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Support Personnel<\/p>\n

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FUNDING<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ min_height=”188px” locked=”off”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/idibe.umh.es\/files\/2020\/01\/ERC-web-IDiBE-Ortega-Villaizan.jpg” align=”center” _builder_version=”4.16″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/idibe.umh.es\/files\/2020\/01\/Blood-Cells-Crosstalk.png” url=”https:\/\/cordis.europa.eu\/project\/id\/639249\/es” url_new_window=”on” align=”center” _builder_version=”4.16″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/idibe.umh.es\/files\/2020\/01\/logo-Ministerio-C-I-U-IDiBE.png” _builder_version=”4.16″ custom_margin=”10px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”30.375px|0px|0|0px|false|false” locked=”off”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.2.2″ header_font=”||||||||” header_text_color=”#c0172d” header_3_font=”||||||||” header_4_font=”||||||||” header_4_text_color=”#c0172d” header_4_font_size=”26px” header_4_line_height=”1.4em” custom_margin=”||8px” custom_padding=”0px|0px|0px|0px|false|true”]<\/p>\n

\"\"\u00a0ORTEGA-VILLAIZ\u00c1N, M. M.<\/span><\/a><\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ custom_padding=”30.375px|0px|0|0px|false|false”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ header_font=”||||||||” header_text_color=”#c0172d” header_3_font=”||||||||” header_4_font=”||||||||” header_4_text_color=”#c0172d” header_4_font_size=”26px” header_4_line_height=”1.4em” custom_margin=”||8px” custom_padding=”0px|0px|0px|0px|false|true”]<\/p>\n

REPRESENTATIVE PUBLICATIONS<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ custom_padding=”15px|0px|15px|0px|true|false” custom_width_px=”1669px”][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”Nombela I. et al. (2019)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true” locked=”off”]<\/p>\n

Vaccines (Basel), DOI: doi.org\/10.3390\/vaccines7030063<\/a><\/p>\n

Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets.<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”Puente-Marin S., et al. (2019)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true” locked=”off”]<\/p>\n

Vaccines (Basel), DOI: doi.org\/10.3390\/vaccines7030060<\/a><\/p>\n

Potencial Role of Rainbow Trout Erytrocytes as Mediators in the Immune Response Induced by a DNA vaccine in Fish.<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ custom_padding=”15px|0px|15px|0px|true|false” custom_width_px=”1669px”][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”puente-marin s., et al. (2019)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”19px|25px|19px|25px|true|”]<\/p>\n

Front Immunol., DOI: doi.org\/10.3389\/fimmu.2019.01055<\/a><\/p>\n

Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNF<\/em>\u03b1 and a G-VHSV Fragment.<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_blurb title=”CHICO, V., et al. (2019)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true” locked=”off”]<\/p>\n

Front Immunol., DOI: doi.org\/10.3389\/fimmu.2019.00613<\/a><\/p>\n

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells.<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ custom_padding=”15px|0px|15px|0px|true|false” custom_width_px=”1669px”][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”NOMBELA I., et al. (2019)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true”]<\/p>\n

Cells, DOI: doi.org\/10.3390\/cells8050386<\/a><\/p>\n

Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Seoticemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86 and Antigen-presenting Cell Markers.<\/i><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”JUNG MH., et al. (2019)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true” locked=”off”]<\/p>\n

Front Immunol., DOI: doi.org\/10.3389\/fimmu.2019.00160<\/a><\/p>\n

The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells.<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ custom_padding=”15px|0px|15px|0px|true|false” custom_width_px=”1669px”][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”CHICO V., et al. (2018)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true” locked=”off”]<\/p>\n

IntechOpen, DOI:\u00a010.5772\/intechopen.80545<\/a><\/p>\n

Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens, Immune Response Activation and Immunomodulation<\/i>.<\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”Puente-Marin S., et al. (2018)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true”]<\/p>\n

Genes, DOI: doi.org\/10.3390\/genes9040202<\/a><\/p>\n

In silico functional networks identified in fish nucleated red blood cells by means of transcriptomic and proteomic profiling<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ custom_padding=”15px|0px|15px|0px|true|false” custom_width_px=”1669px”][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”Chico V., et al. (2018)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true”]<\/p>\n

Cells, DOI: 10.3390\/cells7040031<\/a><\/p>\n

Shape-shifted red blood cells: a novel red blood cell stage?\u00a0.<\/em><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ module_class=”hover_blurb” _builder_version=”4.16″ background_color=”rgba(255,255,255,0.5)” custom_padding=”|||” custom_css_main_element=”box-shadow: 0 20px 80px rgba(50,50,93,.09);” custom_padding__hover=”|||”][et_pb_blurb title=”nombela i. and ortega-villaizan M. M. (2018)” _builder_version=”4.16″ header_font=”Josefin Sans|||on|||||” header_text_align=”left” header_text_color=”#c0172d” header_line_height=”1.2em” body_font=”||||||||” body_line_height=”1.1em” custom_padding=”25px|25px|25px|25px|true” locked=”off”]<\/p>\n

PLOS Pathogens, DOI:\u00a010.1371\/journal.ppat.1006910<\/a><\/p>\n

Nucleated red blood cells: Immune cell mediators of the antiviral response<\/i>.<\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

RESEARCH Red Blood Cells in Antiviral Immunology RESEARCH HIGHLIGHTS The results obtained from our group have demonstrated that rainbow trout RBCs can respond to viral infections by themselves with an innate immune response, by means of producing antiviral molecules and exerting a paracrine antiviral communication with other cells, and with a potential adaptive immune response, […]<\/p>\n","protected":false},"author":3158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

[et_pb_section fb_built=\"1\" _builder_version=\"4.16\" background_image=\"https:\/\/idibe.umh.es\/files\/2022\/09\/colors_light.png\" parallax=\"on\" custom_padding=\"54px|0px|18px|0px|false|false\" locked=\"off\"][et_pb_row _builder_version=\"4.16\" custom_padding=\"28px|0px|29px|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_font_size=\"55px\"]<\/p>

RESEARCH<\/h1>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.16\" background_color=\"#c0172d\" custom_padding=\"16px|0px|16px|0px|false|false\" locked=\"off\"][et_pb_row _builder_version=\"4.16\" custom_padding=\"11px|0px|0|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_font_size=\"55px\" header_2_font=\"Raleway||||||||\" header_2_text_color=\"#ffffff\" header_2_font_size=\"45px\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#ffffff\"]<\/p>

Red Blood Cells in Antiviral Immunology<\/h2>

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RESEARCH HIGHLIGHTS\u00a0<\/h4>

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The results obtained from our group have demonstrated that rainbow trout RBCs can respond to viral infections by themselves with an innate immune response, by means of producing antiviral molecules and exerting a paracrine antiviral communication with other cells, and with a potential adaptive immune response, by means of antigen processing and presentation and complement system regulation.Fish immunology and virology.<\/span><\/p>

\u00a0<\/p>

[\/et_pb_text][et_pb_toggle title=\"SCIENTIFIC INTERESTS\" icon_color=\"#c0172d\" _builder_version=\"4.16\" title_text_color=\"#c0172d\" title_level=\"h4\" title_font=\"||||||||\" body_font=\"||||||||\" background_color=\"#ffffff\" custom_padding=\"32px|32px|32px|32px|true|true\" border_radii=\"on|3px|3px|3px|3px\" border_width_all=\"0px\" box_shadow_style=\"preset1\" box_shadow_color=\"rgba(153,153,153,0.14)\"]<\/p>

Fish are the phylogenetically oldest vertebrate group with an immune system with clear similarities to the immune system of mammals. However, it is an actual matter of fact that the current knowledge of the fish immune system seems to lack the key piece to complete the puzzle.<\/span><\/p>


In 1953 Nelson described a new role of human red blood cells (RBCs) which would go beyond the simple transport of O2 to the tissues. This new role, involved in the defence against microbes, described the antibody and complement-dependent binding of microbial immune complexes to RBCs. Regardless of the importance of this finding in the field of microbial infection, this phenomenon has been poorly evaluated. Just recently, a set of biological processes relevant to immunity have been described in the RBCs of a diverse group of organisms, which include: pathogen recognition, pathogen binding and clearance and cytokines production.
Furthermore, it has been demonstrated that nucleated erythrocytes from fish and avian species develop specific responses to different pathogen associated molecular patterns and produce soluble factors that modulate leukocyte activity.
In the light of these pieces of evidences, and in an attempt to improve the knowledge of the immune mechanism(s) responsible for fish protection against viral infections, we raised the question: could nucleated fish erythrocytes be the key mediators of the antiviral responses? To answer this question we decided to focus our work on the evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. For that we chose a working model composed of the rainbow trout, the viral haemorrhagic septicaemia virus (VHSV) and the glycoprotein G of VHSV (GVHSV), the antigen encoded by this DNA vaccine.<\/span><\/p>

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NEWS<\/h4>

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MEMBERS<\/h4>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_4,1_4,1_4,1_4\" make_equal=\"on\" _builder_version=\"4.16\"][et_pb_column type=\"1_4\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Dr. Mar\u00eda del Mar Ortega Villaiz\u00e1n-Romo\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"center\" header_line_height=\"1.2em\" custom_padding=\"32px|20px|0px|20px\"]<\/p>

Senior Research<\/p>

[\/et_pb_blurb][et_pb_button button_url=\"https:\/\/www.researchgate.net\/profile\/Maria_del_Mar_Ortega-Villaizan\" url_new_window=\"on\" button_text=\"VIEW PROFILE\" button_alignment=\"center\" _builder_version=\"4.16\" custom_button=\"on\" button_text_size=\"15px\" button_text_color=\"#c0172d\" button_bg_color=\"#ffffff\" button_font=\"||||||||\" custom_margin=\"-20px||20px\" button_text_color__hover_enabled=\"on\" button_text_color__hover=\"#ffffff\" button_bg_color__hover_enabled=\"on\" button_bg_color__hover=\"#c0172d\"][\/et_pb_button][\/et_pb_column][et_pb_column type=\"1_4\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Dr. Ver\u00f3nica Chico Gras\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"center\" header_line_height=\"1.2em\" custom_padding=\"32px|20px|0px|20px\"]<\/p>

Postdoctoral Researcher<\/p>

[\/et_pb_blurb][et_pb_button button_url=\"https:\/\/orcid.org\/0000-0001-6983-2786\" url_new_window=\"on\" button_text=\"VIEW PROFILE\" button_alignment=\"center\" _builder_version=\"4.16\" custom_button=\"on\" button_text_size=\"15px\" button_text_color=\"#c0172d\" button_bg_color=\"#ffffff\" button_font=\"||||||||\" custom_margin=\"-20px||20px\" button_text_color__hover_enabled=\"on\" button_text_color__hover=\"#ffffff\" button_bg_color__hover_enabled=\"on\" button_bg_color__hover=\"#c0172d\"][\/et_pb_button][\/et_pb_column][et_pb_column type=\"1_4\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Mar\u00eda Elizabeth Salvador Mira\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"center\" header_line_height=\"1.2em\" custom_padding=\"32px|20px|0px|20px\"]<\/p>

PhD Student<\/p>

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PhD Student<\/p>

[\/et_pb_blurb][et_pb_button button_url=\"https:\/\/www.researchgate.net\/profile\/Celia-Garcia-Quintanilla-2\" url_new_window=\"on\" button_text=\"VIEW PROFILE\" button_alignment=\"center\" _builder_version=\"4.16\" custom_button=\"on\" button_text_size=\"15px\" button_text_color=\"#c0172d\" button_bg_color=\"#ffffff\" button_font=\"||||||||\" custom_margin=\"-20px||20px\" locked=\"off\" button_text_color__hover_enabled=\"on\" button_text_color__hover=\"#ffffff\" button_bg_color__hover_enabled=\"on\" button_bg_color__hover=\"#c0172d\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" custom_padding=\"30.375px|0px|0|0px|false|false\" locked=\"off\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p>

FORMER MEMBERS<\/h4>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_4,1_4,1_4,1_4\" make_equal=\"on\" _builder_version=\"4.16\"][et_pb_column type=\"1_4\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Dr. Sara Puente Mar\u00edn\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"center\" header_line_height=\"1.2em\" custom_padding=\"32px|20px|0px|20px\" locked=\"off\"]<\/p>

Graduated PhD Student<\/p>

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Graduated PhD Student<\/p>

[\/et_pb_blurb][et_pb_button button_url=\"https:\/\/www.researchgate.net\/profile\/Ivan_Nombela\" url_new_window=\"on\" button_text=\"VIEW PROFILE\" button_alignment=\"center\" _builder_version=\"4.16\" custom_button=\"on\" button_text_size=\"15px\" button_text_color=\"#c0172d\" button_bg_color=\"#ffffff\" button_font=\"||||||||\" custom_margin=\"-20px||20px\" locked=\"off\" button_text_color__hover_enabled=\"on\" button_text_color__hover=\"#ffffff\" button_bg_color__hover_enabled=\"on\" button_bg_color__hover=\"#c0172d\"][\/et_pb_button][\/et_pb_column][et_pb_column type=\"1_4\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Remedios Torres Montero\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"center\" header_line_height=\"1.2em\" custom_padding=\"32px|20px|0px|20px\" locked=\"off\"]<\/p>

Support Personnel<\/p>

[\/et_pb_blurb][et_pb_button button_url=\"https:\/\/www.umh.es\/contenido\/Universidad\/:persona_108339\/datos_es.html\" url_new_window=\"on\" button_text=\"VIEW PROFILE\" button_alignment=\"center\" _builder_version=\"4.16\" custom_button=\"on\" button_text_size=\"15px\" button_text_color=\"#c0172d\" button_bg_color=\"#ffffff\" button_font=\"||||||||\" custom_margin=\"-20px||20px\" locked=\"off\" button_text_color__hover_enabled=\"on\" button_text_color__hover=\"#ffffff\" button_bg_color__hover_enabled=\"on\" button_bg_color__hover=\"#c0172d\"][\/et_pb_button][\/et_pb_column][et_pb_column type=\"1_4\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Efr\u00e9n Lucas Ma\u00f1ogil\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"center\" header_line_height=\"1.2em\" custom_padding=\"32px|20px|0px|20px\" locked=\"off\"]<\/p>

Support Personnel<\/p>

[\/et_pb_blurb][et_pb_button button_url=\"https:\/\/www.umh.es\/contenido\/Universidad\/:persona_130482\/datos_es.html\" url_new_window=\"on\" button_text=\"VIEW PROFILE\" button_alignment=\"center\" _builder_version=\"4.16\" custom_button=\"on\" button_text_size=\"15px\" button_text_color=\"#c0172d\" button_bg_color=\"#ffffff\" button_font=\"||||||||\" custom_margin=\"-20px||20px\" locked=\"off\" button_text_color__hover_enabled=\"on\" button_text_color__hover=\"#ffffff\" button_bg_color__hover_enabled=\"on\" button_bg_color__hover=\"#c0172d\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" custom_padding=\"30.375px|0px|0|0px|false|false\" locked=\"off\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p>

FUNDING<\/h4>

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\"\"\u00a0ORTEGA-VILLAIZ\u00c1N, M. M.<\/span><\/a><\/h4>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.16\" custom_padding=\"30.375px|0px|0|0px|false|false\"][et_pb_column type=\"4_4\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.16\" header_font=\"||||||||\" header_text_color=\"#c0172d\" header_3_font=\"||||||||\" header_4_font=\"||||||||\" header_4_text_color=\"#c0172d\" header_4_font_size=\"26px\" header_4_line_height=\"1.4em\" custom_margin=\"||8px\" custom_padding=\"0px|0px|0px|0px|false|true\"]<\/p>

REPRESENTATIVE PUBLICATIONS<\/h4>

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Nombela I. et al. (2019)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p>

Vaccines (Basel), DOI: doi.org\/10.3390\/vaccines7030063<\/a><\/p>

Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets.<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Puente-Marin S., et al. (2019)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p>

Vaccines (Basel), DOI: doi.org\/10.3390\/vaccines7030060<\/a><\/p>

Potencial Role of Rainbow Trout Erytrocytes as Mediators in the Immune Response Induced by a DNA vaccine in Fish.<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"puente-marin s., et al. (2019)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"19px|25px|19px|25px|true|\"]<\/p>

Front Immunol., DOI: doi.org\/10.3389\/fimmu.2019.01055<\/a><\/p>

Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNF<\/em>\u03b1 and a G-VHSV Fragment.<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.16\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"CHICO, V., et al. (2019)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p>

Front Immunol., DOI: doi.org\/10.3389\/fimmu.2019.00613<\/a><\/p>

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells.<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"NOMBELA I., et al. (2019)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\"]<\/p>

Cells, DOI: doi.org\/10.3390\/cells8050386<\/a><\/p>

Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Seoticemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86 and Antigen-presenting Cell Markers.<\/i><\/p>

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"JUNG MH., et al. (2019)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p>

Front Immunol., DOI: doi.org\/10.3389\/fimmu.2019.00160<\/a><\/p>

The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells.<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"CHICO V., et al. (2018)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p>

IntechOpen, DOI:\u00a010.5772\/intechopen.80545<\/a><\/p>

Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens, Immune Response Activation and Immunomodulation<\/i>.<\/p>

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Puente-Marin S., et al. (2018)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\"]<\/p>

Genes, DOI: doi.org\/10.3390\/genes9040202<\/a><\/p>

In silico functional networks identified in fish nucleated red blood cells by means of transcriptomic and proteomic profiling<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.16\" custom_padding=\"15px|0px|15px|0px|true|false\" custom_width_px=\"1669px\"][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"Chico V., et al. (2018)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\"]<\/p>

Cells, DOI: 10.3390\/cells7040031<\/a><\/p>

Shape-shifted red blood cells: a novel red blood cell stage?\u00a0.<\/em><\/p>

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" module_class=\"hover_blurb\" _builder_version=\"4.16\" background_color=\"rgba(255,255,255,0.5)\" custom_padding=\"|||\" custom_css_main_element=\"box-shadow: 0 20px 80px rgba(50,50,93,.09);\" custom_padding__hover=\"|||\"][et_pb_blurb title=\"nombela i. and ortega-villaizan M. M. (2018)\" _builder_version=\"4.16\" header_font=\"Josefin Sans|||on|||||\" header_text_align=\"left\" header_text_color=\"#c0172d\" header_line_height=\"1.2em\" body_font=\"||||||||\" body_line_height=\"1.1em\" custom_padding=\"25px|25px|25px|25px|true\" locked=\"off\"]<\/p>

PLOS Pathogens, DOI:\u00a010.1371\/journal.ppat.1006910<\/a><\/p>

Nucleated red blood cells: Immune cell mediators of the antiviral response<\/i>.<\/p>

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"_links":{"self":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/3873"}],"collection":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/users\/3158"}],"replies":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/comments?post=3873"}],"version-history":[{"count":0,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/pages\/3873\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media?parent=3873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}