{"id":24716,"date":"2025-11-04T08:00:11","date_gmt":"2025-11-04T08:00:11","guid":{"rendered":"https:\/\/idibe.umh.es\/?p=24716"},"modified":"2025-11-03T11:01:47","modified_gmt":"2025-11-03T11:01:47","slug":"new-publication-by-our-researcher-jose-villalain-at-idibe","status":"publish","type":"post","link":"https:\/\/idibe.umh.es\/en\/2025\/11\/04\/new-publication-by-our-researcher-jose-villalain-at-idibe\/","title":{"rendered":"New publication by our researcher Jos\u00e9 Villala\u00edn at IDiBE"},"content":{"rendered":"<p style=\"text-align: justify\" data-start=\"218\" data-end=\"496\">Our researcher <strong data-start=\"233\" data-end=\"251\">Jos\u00e9 Villala\u00edn<\/strong> has just published a new paper titled<br data-start=\"289\" data-end=\"292\" \/><strong data-start=\"292\" data-end=\"383\">\u201cErgothioneine Thione Spontaneously Binds to and Detaches from the Membrane Interphase\u201d<\/strong> (<em data-start=\"385\" data-end=\"396\">Membranes<\/em>, 2025, 15(11), 328; DOI: <a class=\"decorated-link cursor-pointer\" target=\"_new\" rel=\"noopener\" data-start=\"422\" data-end=\"492\">10.3390\/membranes15110328<\/a>).<\/p>\n<p style=\"text-align: justify\" data-start=\"498\" data-end=\"701\">This study uses <strong data-start=\"514\" data-end=\"548\">molecular dynamics simulations<\/strong> to explore the behavior of <strong data-start=\"576\" data-end=\"593\">ergothioneine<\/strong>, a powerful natural antioxidant with growing relevance in <strong data-start=\"652\" data-end=\"698\">cosmetics, nutraceuticals, and biomedicine<\/strong>.<\/p>\n<p style=\"text-align: justify\" data-start=\"703\" data-end=\"934\">The work sheds new light on how this molecule interacts with <strong data-start=\"764\" data-end=\"788\">biological membranes<\/strong>, offering valuable insights into its <strong data-start=\"826\" data-end=\"870\">protective role against oxidative stress<\/strong> and its <strong data-start=\"879\" data-end=\"931\">potential applications for health and well-being<\/strong>.<\/p>\n<p style=\"text-align: justify\" data-start=\"936\" data-end=\"1152\">Produced naturally by fungi, algae, and bacteria, <strong data-start=\"986\" data-end=\"1003\">ergothioneine<\/strong> has been linked to benefits in <strong data-start=\"1035\" data-end=\"1103\">metabolic, cardiovascular, neurodegenerative, and liver diseases<\/strong>, as well as notable <strong data-start=\"1124\" data-end=\"1149\">anti-aging properties<\/strong>.<\/p>\n<p style=\"text-align: justify\" data-start=\"1154\" data-end=\"1445\">In this research, Villala\u00edn demonstrates that the <strong data-start=\"1204\" data-end=\"1226\">thione form (ERGO)<\/strong> of the molecule can <strong data-start=\"1247\" data-end=\"1299\">spontaneously insert into the interfacial region<\/strong> of biological membranes, moving freely between the aqueous environment and the membrane without disrupting its structure or forming aggregates.<\/p>\n<p style=\"text-align: justify\" data-start=\"1447\" data-end=\"1608\">These findings reveal new <strong data-start=\"1473\" data-end=\"1497\">mechanisms of action<\/strong> for ergothioneine and expand our understanding of how <strong data-start=\"1552\" data-end=\"1605\">natural antioxidants interact with cell membranes<\/strong>.<\/p>\n<p style=\"text-align: justify\" data-start=\"1610\" data-end=\"1807\">A fascinating study that combines <strong data-start=\"1644\" data-end=\"1708\">molecular biology, biophysics, and computational simulations<\/strong> to unravel the connection between structure and function in biomolecules of biomedical interest.<\/p>\n<p style=\"text-align: justify\" data-start=\"1809\" data-end=\"1893\">\ud83d\udcd6 <strong data-start=\"1812\" data-end=\"1838\">Read the full article:<\/strong><br data-start=\"1838\" data-end=\"1841\" \/><a class=\"decorated-link\" href=\"https:\/\/lnkd.in\/dFNeMNWS\" target=\"_new\" rel=\"noopener\" data-start=\"1841\" data-end=\"1893\">https:\/\/lnkd.in\/dFNeMNWS<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our researcher Jos\u00e9 Villala\u00edn has just published a new paper titled\u201cErgothioneine Thione Spontaneously Binds to and Detaches from the Membrane Interphase\u201d (Membranes, 2025, 15(11), 328; DOI: 10.3390\/membranes15110328). This study uses molecular dynamics simulations to explore the behavior of ergothioneine, a powerful natural antioxidant with growing relevance in cosmetics, nutraceuticals, and biomedicine. The work sheds new [&hellip;]<\/p>\n","protected":false},"author":30306,"featured_media":24719,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/posts\/24716"}],"collection":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/users\/30306"}],"replies":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/comments?post=24716"}],"version-history":[{"count":0,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/posts\/24716\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media\/24719"}],"wp:attachment":[{"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/media?parent=24716"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/categories?post=24716"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibe.umh.es\/en\/wp-json\/wp\/v2\/tags?post=24716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}