LATEST PUBLICATIONS

SOLUTION-ORIENTED SCIENTIFIC RESEARCH

At IDiBE we promote quality over quantity. We not only aim for impact and excellence in publications; we focus on developing real, effective solutions to healthcare problems.

Nikolaeva-Koleva, M. et al. (2021)

Scientific Reports, DOI: 10.1038/s41598-020-80725-z

A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability

Álvarez-Martínez, F. J. et al. (2021)

Scientific Reports, DOI: 10.1038/s41598-020-80003-y

The antimicrobial capacity of Cistus salviifolius and Punica granatum plant extracts against clinical pathogens is related to their polyphenolic composition

Marroquí, L. et al. (2021)

Chemosphere, DOI: 10.1016/j.chemosphere.2020.129051

Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway

Fernández-Carvajal, A. et al. (2020)

Expert Opinion on Investigational Drugs, DOI: 10.1080/13543784.2020.1825680

Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels

Dionisi, M. et al. (2020)

International Journal of Molecular Sciences, DOI: 10.3390/ijms21197164

Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification

Muncke, J. et al. (2020)

Environmental Health, DOI: 10.1186/s12940-020-0572-5

Impacts of food contact chemicals on human health: a consensus statement

Legler, J. et al. (2020)

International Journal of Molecular Sciences, DOI: 10.3390/ijms21103480

The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds

Álvarez-Martínez, F. J. et al. (2020)

Biomedicines, DOI: 10.3390/biomedicines8100405

Tackling Antibiotic Resistance with Compounds of Natural Origin: A Comprehensive Review

Fernández-Ballester, G. et al. (2020)

Expert Opinion on Therapeutic Targets, DOI: 10.1080/14728222.2020.1820987

Targeting thermoTRP ion channels: in silico preclinical approaches and opportunities

Quesada-Candela, C. et al. (2020)

Metabolism, DOI: 10.1016/j.metabol.2019.153963

Morphological and functional adaptations of pancreatic alpha-cells during late pregnancy in the mouse

Bonache, M. A. et al. (2020)

Scientific Reports, DOI: 10.1038/s41598-020-70691-x

Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

Bertamino, A. et al. (2020)

Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.0c00816

Exploration of TRPM8 Binding Sites by β-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities

Pozuelo-Sánchez, I. et al. (2020)

Journal of Agricultural and Food Chemistry, DOI: 10.1021/acs.jafc.9b06801

Postprandial Lipemia Modulates Pancreatic Alpha-Cell Function in the Prediction of Type 2 Diabetes Development: The CORDIOPREV Study

Journigan, V. B. et al. (2020)

ACS Chemical Neuroscience, DOI: 10.1021/acschemneuro.9b00404

Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies

Boronat-Belda, T. et al. (2020)

Food and Chemical Toxicology, DOI: 10.1016/j.fct.2020.111681

Bisphenol-A exposure during pregnancy alters pancreatic β-cell division and mass in male mice offspring: A role for ERβ

Almenara, S. et al. (2020)

Hepatology International, DOI: 10.1007/s12072-020-10083-5

Functionality of beta-adrenergic receptors in patients with cirrhosis treated chronically with non-selective beta-blockers

Renart M. L., et al. (2020)

International Journal of Molecular Sciences, DOI: 10.3390/ijms21072554

Modulation of Function, Structure and Clustering of K+ Channels by Lipids: Lessons Learnt from KcsA

Encinar J. A. & Menéndez J. A. (2020)

Viruses, DOI: 10.3390/v12050525

Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2’-O-Methylation of Viral RNA

Agulló-Chazarra L., et al. (2020)

Antioxidants, DOI: 10.3390/antiox9050418

Sweet Cherry Byproducts Processed by Green Extraction Techniques as a Source of Bioactive Compounds with Antiaging Propertie

Sánchez-Marzo N., et al. (2020)

Antioxidants, DOI: 10.3390/antiox9030255

Rosemary Diterpenes and Flavanone Aglycones Provide Improved Genoprotection against UV-Induced DNA Damage in a Human Skin Cell Model

Cuyás E., et al. (2020)

Aging, DOI: 10.18632/aging.102887

The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes

Verdura S., et al. (2020)

Aging, DOI: 10.18632/aging.102646

Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity

Bello-Pérez M., et al. (2020)

Scientific Reports, DOI: 10.1038/s41598-020-57501-0

Zebrafish C-reactive protein isoforms inhibit SVCV replication by blocking autophagy through interactions with cell membrane cholesterol

Alonso-Magdalena, P. & Nadal, A. (2020)

Endocrinology, DOI: 10.1210/endocr/bqaa123

The Commonly Overlooked Factor. Commentary on: “Environmental Obesogens and their Impact on Susceptibility to Obesity”

Galiano V., et al. (2020)

The Journal of Membrane Biology, DOI: 10.1007/s00232-020-00106-5

Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane

Cobo R., et al. (2019)

Neuroscience, DOI: 10.1016/j.neuroscience.2019.05.043

Mechanisms of Blockade of the Muscle-Type Nicotinic Receptor by Benzocaine, a Permanently Uncharged Local Anesthetic

Soriano, R. et al. (2019)

Molecular and Cellular Endocrinology, DOI: 10.1016/j.mce.2018.09.009

Cortistatin regulates glucose-induced electrical activity and insulin secretion in mouse pancreatic beta-cells

Giudici A. M., et al. (2019)

International Journal of Molecular Sciences, DOI: 10.3390/ijms20030689

Accessibility of Cations to the Selectivity Filter of KcsA in the Inactivated State: An Equilibrium Binding Study

Nikolaeva Koleva M. & Fernández-Ballester G. (2019)

In Silico Approaches for TRP Channel Modulation. In TRP Channels, DOI: 10.1007/978-1-4939-9446-5_12

In Silico Approaches for TRP Channel Modulation

Cordero-Sánchez C., et al. (2019)

In Silico Approaches for TRP Channel Modulation. In TRP Channels, DOI: 10.1007/978-1-4939-9446-5_7

Fluorescence-Based Functional Assays for Ca2+-Permeable ThermoTRP Channels

Martínez-Ortega L., et al. (2019)

Pharmaceutics, DOI: 10.3390/pharmaceutics11010014

Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment

Bru-Tari, E. et al. (2019)

Scientific Reports, DOI: 10.1038/s41598-019-45853-1

Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes

Martínez-Pinna, J. et al. (2019)

Diabetologia, DOI: 10.1007/s00125-019-4925-y

Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells

González-Gil I., et al. (2019)

Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.9b01287

A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration

Pérez de Vega M. J., et al. (2019)

ACS Chem. Neurosci., DOI: 10.1021/acschemneuro.9b00364

1-(2′,5′-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity

Solé L., et al. (2019)

The FASEB Journal, DOI: 10.1096/fj.201801164RR

The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3

Arribas-Blázquez M., et al. (2019)

International Journal of Molecular Sciences, DOI: 10.3390/ijms20010155

Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain

Poveda J. A., et al. (2019)

Biochimica et Biophysica Acta-Biomembranes, DOI: 10.1016/j.bbamem.2019.183029

Modulation of the potassium channel KcsA by anionic phospholipids: Role of arginines at the non-annular lipid binding sites

Renart M. L., et al. (2019)

Scientific Reports, DOI: doi.org/10.1038/s41598-019-42405-5

Conformational plasticity in the KcsA potassium channel pore helix revealed by homo-FRET studies

Olivares-Vicente M., et al. (2019)

Nutrients, DOI: 10.3390/nu11122961

The Potential Synergistic Modulation of AMPK by Lippia citriodora Compounds as a Target in Metabolic Disorders

Ruiz-Torres V., et al. (2019)

Biomolecules, DOI: doi.org/10.3390/biom9120771

Marine Invertebrate Extracts Induce Colon Cancer Cell Death via ROS-Mediated DNA Oxidative Damage and Mitochondrial Impairment

Nombela I., et al. (2019)

Cells, DOI: 10.3390/cells8050386

Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers

Jung M-H., et al. (2019)

Front. Immunol., DOI: 10.3389/fimmu.2019.00160

The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells

Puente-Marín S., et al. (2019)

Front. Immunol., DOI: 10.3389/fimmu.2019.01055

Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFα and a G-VHSV Fragment

Chico V., et al. (2019)

Front. Immunol., DOI: 10.3389/fimmu.2019.00613

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells

Nombela I., et al. (2019)

Vaccines, DOI: 10.3390/vaccines7030063

Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets

Puente-Marín S., et al. (2019)

Vaccines, DOI: 10.3390/vaccines7030060

Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish

Cuyás E., et al. (2019)

Food and Chemical Toxicology, DOI: 10.1016/j.fct.2019.110645

Revisiting silibinin as a novobiocin-like Hsp90 C-terminal inhibitor: Computational modeling and experimental validation

Cuyàs E., et al. (2019)

Food and Chemical Toxicology, DOI: 10.1016/j.fct.2019.03.049

The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase

Cuyás E., et al. (2019)

Nutrients, DOI: 10.3390/nu11071656

Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A

BELLO-pÉREZ m., et al. (2019)

Plos One, DOI: 10.1371/journal.pone.0201509

Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms

Villalaín J. (2019)

Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2018.1508372

Epigallocatechin-3-gallate location and interaction with late endosomal and plasma membrane model membranes by molecular dynamics

Carpio L. E., et al. (2019)

Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2019.1697368

Identification of the phospholipid binding regions of the envelope E protein of flaviviruses by molecular dynamics

Tuduri E., et al. (2018)

Frontiers in Endocrinology, DOI: 10.3389/fendo.2018.00648

Timing of Exposure and Bisphenol-A: Implications for Diabetes Development

Ruiz-Torres V., et al. (2018)

Marine Drugs, DOI: 10.3390/md16100385

New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques

Alvarez-Martinez F.J., et al. (2018)

Current Medicinal Chemistry, DOI: 10.2174/0929867325666181008115650

Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review

Artero-Morales M., et al. (2018)

Frontiers in Molecular Biosciences 5, DOI: 10.3389/fmolb.2018.00073

TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain

Balsera B., et al. (2018)

European Journal of Medicinal Chemistry 143, 157-165, DOI: 10.1016/j.ejmech.2017.10.083

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity

Bello-Gil D., et al. (2018)

Applied and Environmental Microbiology 84, doi: 10.1128/AEM.02595-17

Poly-3-Hydroxybutyrate Functionalization with BioF-Tagged Recombinant Proteins

Bello-Gil D., et al. (2018)

Microbial Biotechnology 11, 881-892, DOI: 10.1111/1751-7915.13287

An enzymatic system for decolorization of wastewater dyes using immobilized CueO laccase‐like multicopper oxidase on poly‐3‐hydroxybutyrate

Bertamino A., et al. (2018)

Journal of Medicinal Chemistry 61, 6140-6152, DOI: 10.1021/acs.jmedchem.8b00545

Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity

Boix-Castejon M., et al. (2018)

Food and Function 9, 4037, DOI: 10.1039/c8fo90028k

Correction: Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial

Cadiz-Gurrea M. D. L. L., et al. (2018)

Journal of Functional Foods 46, 514-520, DOI: 10.1016/j.jff.2018.05.026

Bioassay-guided purification of Lippia citriodora polyphenols with AMPK modulatory activity

Contreras L. M., et al. (2018)

International Journal of Molecular Sciences 19, DOI: 10.3390/ijms19071857

The Cyanobacterial Ribosomal-Associated Protein LrtA from Synechocystis sp. PCC 6803 Is an Oligomeric Protein in Solution with Chameleonic Sequence Properties

Coomans de Brachène A., et al. (2018)

Diabetologia 61, 636-640, DOI: 10.1007/s00125-017-4536-4

IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

Corominas-Faja B., et al. (2018)

Carcinogenesis 39, 601-613, DOI: 10.1093/carcin/bgy023

Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells

de la Luz Cadiz-Gurrea M., et al. (2018)

Food Research International, DOI: 10.1016/j.foodres.2018.02.027

Different behavior of polyphenols in energy metabolism of lipopolysaccharide-stimulated cells

de-Madaria E., et al. (2018)

United European Gastroenterology Journal 6, 63-72, DOI: 10.1177/2050640617707864

Fluid resuscitation with lactated Ringer’s solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial

Gallo F., et al. (2018)

Environmental Sciences Europe 30, DOI: 10.1186/s12302-018-0139-z

Marine litter plastics and microplastics and their toxic chemicals components: the need for urgent preventive measures

Gomez-Hurtado I., et al. (2018)

Liver International 38, 295-302, DOI: 10.1111/liv.13551

Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis

Gomez-Hurtado I., et al. (2018)

European Journal of Nutrition, 1-12, DOI: 10.1007/s00394-018-1709-y

Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765

Juan-Mateu J., et al. (2018)

Diabetes 67, 423-436, DOI: 10.2337/db17-0736

SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival

Lama R., et al. (2018)

Fish and Shellfish Immunology 82, 190-199, DOI: 10.1016/j.fsi.2018.08.004

Turbot (Scophthalmus maximus) Nk-lysin induces protection against the pathogenic parasite Philasterides dicentrarchi via membrane disruption

Lucioli S., et al. (2018)

Journal of Photochemistry and Photobiology B: Biology 188, 69-76, DOI: 10.1016/j.jphotobiol.2018.09.002

Anthocyanic pigments from elicited in vitro grown shoot cultures of Vaccinium corymbosum L., cv. Brigitta Blue, as photosensitizer in natural dye-sensitized solar cells (NDSSC)

M. Medina-Gali R., et al. (2018)

Developmental and Comparative Immunology 84, 307-314, DOI: 10.1016/j.dci.2018.02.019

Beta-glucan enhances the response to SVCV infection in zebrafish

Mangas-Sanjuan C., et al. (2018)

United European Gastroenterology Journal 6, 622-629, DOI: 10.1177/2050640617745458

Importance of endoscopist quality metrics for findings at surveillance colonoscopy: The detection-surveillance paradox

Martinez-Pinna J., et al. (2018)

Frontiers in Physiology 9, DOI: 10.3389/fphys.2018.00508

A Calcium-Dependent Chloride Current Increases Repetitive Firing in Mouse Sympathetic Neurons

Medina-Gali R., et al. (2018)

Fish and Shellfish Immunology 82, 514-521, DOI: 10.1016/j.fsi.2018.08.056

Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response

Murcia O., et al. (2018)

PLoS ONE 13, DOI: 10.1371/journal.pone.0203051

Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy

Nadal A., et al. (2018)

Journal of Steroid Biochemistry and Molecular Biology 176, 16-22, DOI: 10.1016/j.jsbmb.2017.01.014

Extranuclear-initiated estrogenic actions of endocrine disrupting chemicals: Is there toxicology beyond paracelsus?

Neira J. L., et al. (2018)

Archives of Biochemistry and Biophysics 639, 26-37, DOI: 10.1016/j.abb.2017.12.017

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments

Neira J. L., et al. (2018)

Biochemical Journal 475, 2271-2291, DOI: 10.1042/BCJ20180365

The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue

Nombela I., and Ortega-Villaizan, M. D. M. (2018)

PLoS Pathogens 14, DOI: 10.1371/journal.ppat.1006910

Nucleated red blood cells: Immune cell mediators of the antiviral response

Nuñez P., et al. (2018)

Journal of Developmental Origins of Health and Disease 9, 208-214, DOI: 10.1017/S2040174417000939

Effects of bisphenol A treatment during pregnancy on kidney development in mice: a stereological and histopathological study

Olivares-Vicente M., et al. (2018)

Current Drug Metabolism 19, 351-369, DOI: 10.2174/1389200219666180220095236

Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

Ortega-Villaizan M. M., et al. (2018)

F1000Research 6, DOI: 10.12688/f1000research.12985.2

Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus [version 2; peer review: 2 approved, 1 approved with reservations]

Perez-Sanchez, A., et al. (2018)

Nutrients 10, DOI: 10.3390/nu10040403

Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies

Puente-Marin S., et al. (2018)

Genes 9, DOI: 10.3390/genes9040202

In Silico Functional Networks Identified in Fish Nucleated Red Blood Cells by Means of Transcriptomic and Proteomic Profiling

Ranieri L., et al. (2018)

Arthritis Research and Therapy 20, DOI: 10.1186/s13075-018-1559-2

Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort

Roca R., et al. (2018)

Molecular Medicine Reports 17, 7987-7995, DOI: 10.3892/mmr.2018.8820

β2‑adrenergic receptor functionality and genotype in two different models of chronic inflammatory disease: Liver cirrhosis and osteoarthritis

Santofimia-Castaño P., et al. (2018)

Biochimica et Biophysica Acta – General Subjects 1862, 1283-1295, DOI: 10.1016/j.bbagen.2018.03.009

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)

Serafini M., et al. (2018)

Journal of Medicinal Chemistry 61, 4436-4455, DOI: 10.1021/acs.jmedchem.8b00109

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders

Vazquez-Guillo R., et al. (2018)

Polymers 10, DOI: 10.3390/polym10020215

Advantageous Microwave-Assisted Suzuki Polycondensation for the Synthesis of Aniline-Fluorene Alternate Copolymers as Molecular Model with Solvent Sensing Properties

Vazquez-Guillo R., et al. (2018)

Polymers 10, DOI: 10.3390/polym10090938

Synthesis and Characterization of a Novel Green Cationic Polyfluorene and Its Potential Use as a Fluorescent Membrane Probe

Verdura S., et al. (2018)

Food and Chemical Toxicology 116, 161-172, DOI: 10.1016/j.fct.2018.04.028

Silibinin is a direct inhibitor of STAT3

Villamayor L., et al. (2018)

Diabetes 67, 448-460, DOI: 10.2337/db17-0364

GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells

Zamora-Carreras H., et al. (2018)

Chemistry – A European Journal 24, 5825-5839, DOI: 10.1002/chem.201704802

Roles of Amphipathicity and Hydrophobicity in the Micelle‐Driven Structural Switch of a 14‐mer Peptide Core from a Choline‐Binding Repeat

Zapater P. (2018)

Revista Clinica Española 218, 190-191, DOI: 10.1016/j.rce.2018.03.007

Los estudios genéticos y la enfermedad hepática alcohólica (Genetic studies and alcoholic liver disease)

REACH US

Avenida de la Universidad, s/n.
Edificio Torregaitán.
03202 Elche, Alicante, Spain

+ 34 96-665 8759

info.idibe@umh.es (Contact and Information)

idibe@umh.es (Communication and Social Media)