Thanks to our collaboration with the Infectios Diseases Unit of the General Hospital of Elche-Fisabio foundation we publised together a paper in the Journal Clinical Infectious Diseases entitled “Virological History Predicts Non-sustained Viral Suppression with Long-Acting Cabotegravir and Rilpivirine Therapy, independent of Pharmacokinetic Parameters”.
This study investigated the factors contributing to non-sustained viral suppression, such as intermittent viremia and persistent low-level viremia, during long-acting (LA) injectable therapy with cabotegravir (CAB) and rilpivirine (RPV), with a specific focus on pharmacokinetics (PK). The findings suggest that non-sustained viral suppression in people with HIV (PWH) transitioning from stable oral ART to CAB+RPV LA was associated with pre-existing factors prior to the transition. Elevated viral loads before ART initiation and incomplete suppression during oral therapy increased the risk, regardless of PK parameters.
Congrats to Félix Gutiérrez, Marta Fernández González, Christian Ledesma, María Losada Echeberria, Enrique Barrajón-Catalán, Javier García-Abellán, Daria De Stefano, Leandro López, Melissa Belló Pérez, Sergio Padilla and Mar Masiá
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