Development of biomolecules (CLEVER) is a platform that assembles the know-how and technology aimed at the identification and development of bioactive molecules from computational tracking (in silico) to their therapeutic, nutraceutical and/or cosmeceutical validation. It uses natural and synthetic chemical libraries and brings together pre-clinical assays and models to characterize the function of active molecules. Additionally, it provides analytical technology to characterize their pharmacological properties. For natural chemical libraries, it includes a pilot plant for scaling up optimization of plant extracts.
Some of the equipment that is part of the CLEVER technological platform is listed below:
- UHPLC-MS chromatographic unit, Nexera, triple quadrupole LCMS-8050GC for Mass Spectrometer
- UV/Vis analytical HPLC-DAD 7000
- HPLC-DAD mass spectrometry with electrospray ionization ion trap
- Spray-dryer 290
- Cytation 3 Plate Reader
- Biosafety Laboratory Level 2
- 2 high-throughput clusters for molecular modeling and virtual screening.
- 1 cluster of computers with a total of 4 Intel Xeon nodes and up to 40 processors.
- 1 high-performance cluster for scientific computing provided with 8 nodes with Intel Xeon
- Platinum v5 8160-2.1GHz and Intel Xeon Gold 5120 processors, with 24 cores each, and Tesla V-100 or Nvidia CUDA graphics cards.